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New CT tool could spot hidden fracture risk in COPD patients

NCT ID NCT03534934

Knowledge-focused Sponsor: Punam K Saha Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether CT scans can better measure bone health and predict fracture risk in 560 smokers with and without COPD. Researchers used CT images of the spine and ankle to assess bone structure, alongside standard bone density tests. The goal is to create a more accurate tool for identifying osteoporosis risk in COPD patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a new CT-based tool that better predicts fracture risk in COPD patients, helping doctors prevent bone breaks.
What could go wrong
This is an observational study, not a treatment trial. The tool may not work as well in real-world settings or across different CT scanners.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

560 people

The number who actually took part.

Started

Feb 2019

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current or former smoker, defined as having at least 10-pack year lifetime history * Age: 45-90 Subjects will be stratified into groups based on COPD disease status: smokers with COPD and smokers without COPD. Smokers with COPD will be further stratified into three groups: low emphysema (\< 3%), moderate emphysema (between 3 and 10%), and severe emphysema (\> 10%). Exclusion Criteria: * Pregnant or breast-feeding * Metastatic Malignancy * Currently receiving dialysis * Any lower extremity fracture within the last year * Any lower extremity fracture with hardware implant(s) * History of bilateral tibia fractures

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset osteoporosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoporosis Pulmonary disease, chronic obstructive

Contacts and locations

Locations

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

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