Can a One-Time bone drug shield Parkinson's patients from fractures?

NCT ID NCT03924414

Completed Prevention Sponsor: California Pacific Medical Center Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were followed for at least two years. The trial was conducted at home to make participation easier.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

zoledronic acid (Reclast)

What this could lead to

If it works, this could provide a simple, one-time treatment to reduce fracture risk in older adults with Parkinson's disease.

What could go wrong

This is a completed Phase 4 trial, but results are not yet published. The benefit may be modest, and zoledronic acid can cause side effects like flu-like symptoms or kidney issues.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

corticobasal degeneration disorder Lewy body dementia Lewy Body Disease multiple system atrophy osteoporosis Parkinson disease parkinsonian disorder progressive supranuclear palsy vascular parkinsonism bone fracture prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL PARKINSONISM DEMENTIA WITH LEWY BODIES MULTIPLE SYSTEM ATROPHY OSTEOPOROSIS PARKINSON DISEASE PARKINSON'S DISEASE AND PARKINSONISM PARKINSONISM PROGRESSIVE SUPRANUCLEAR PALSY VASCULAR PARKINSONISM

Contacts and locations

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Locations

Albany Medical College

Albany, New York, 12208, United States
Augusta University

Augusta, Georgia, 30912, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Booth Gardner Parkinson's Care Center at EvergreenHealth

Kirkland, Washington, 98034, United States
Boston University

Boston, Massachusetts, 02215, United States
Case Western Reserve University, UH Cleveland

Cleveland, Ohio, 44106, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Columbia University

New York, New York, 10032, United States
Cook County Health & Hospitals System

Chicago, Illinois, 60612, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03766, United States
Duke University

Durham, North Carolina, 27708, United States
Edward Hines, Jr. VA Hospital

Hines, Illinois, 60141, United States
Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Hartford Healthcare

Hartford, Connecticut, 06103, United States
Houston Methodist Neurological Institute

Houston, Texas, 77030, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Loma Linda University

Loma Linda, California, 92350, United States
Loyola University

Chicago, Illinois, 60660, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Scottsdale, Arizona, 85259, United States
Mayo Clinic

Jacksonville, Florida, 32224, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Michigan State University

East Lansing, Michigan, 48824, United States
Morehouse School of Medicine

Atlanta, Georgia, 30310, United States
Mount Sinai Beth Israel

New York, New York, 10019, United States
New York University Langone Health

New York, New York, 10017, United States
Northwell Health

Glen Cove, New York, 11542, United States
Northwell Health

Great Neck, New York, 11021, United States
Northwell Health

Manhasset, New York, 11030, United States
Northwestern Medicine

Chicago, Illinois, 60611, United States
Ochsner Health System

New Orleans, Louisiana, 70119, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Parkinson's Disease and Movement Disorder Center of Silicon Valley

Palo Alto, California, 94301, United States
Parkinson's Foundation

Miami, Florida, 33131, United States
Parkinson's and Movement Disorder Institute

Fountain Valley, California, 92708, United States
Queens Medical Center

Honolulu, Hawaii, 96813, United States
Quest Research Institute

Farmington Hills, Michigan, 48334, United States
Rush University

Chicago, Illinois, 60612, United States
St. Mary's Medical Center

Grand Junction, Colorado, 81501, United States
Stony Brook University Medical Center

East Setauket, New York, 11733, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Sutter Health

Berkeley, California, 94705, United States
Sutter Health

Sacramento, California, 95816, United States
The Ohio State University

Columbus, Ohio, 43210, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California, Davis

Sacramento, California, 95816, United States
University of California, Irvine

Irvine, California, 92697, United States
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of California, Riverside

Riverside, California, 92521, United States
University of California, San Francisco

San Francisco, California, 94115, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Colorado, Denver

Aurora, Colorado, 80045, United States
University of Connecticut

Farmington, Connecticut, 06030, United States
University of Connecticut

Farmington, Connecticut, 06032, United States
University of Florida

Gainesville, Florida, 32611, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Kentucky

Lexington, Kentucky, 40506, United States
University of Miami

Miami, Florida, 33146, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15260, United States
University of Rochester

Rochester, New York, 14642, United States
University of Texas Health Houston Medical Center

Houston, Texas, 77030, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Utah

Salt Lake City, Utah, 84112, United States
University of Vermont

Burlington, Vermont, 05405, United States
University of Wisconsin

Madison, Wisconsin, 53706, United States
Valley Parkinson Clinic

Los Gatos, California, 95032, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37240, United States
Veracity Neuroscience LLC

Memphis, Tennessee, 38157, United States
Wake Forest University

Winston-Salem, North Carolina, 27109, United States
Washington Regional Medical Center

Fayetteville, Arkansas, 72703, United States
Weill Cornell Medicine

New York, New York, 10065, United States