MULTIPLE SYSTEM ATROPHY

This study continues testing an oral medication called TEV-56286 for people with multiple system atrophy (MSA), a rare and progressive brain disorder. It follows 200 participants from a previous trial to monitor the drug's long-term safety over approximately two years. The main g…

This early-stage study is testing whether a nasal spray called foralumab can reduce harmful brain inflammation and slow disease progression in people with multiple system atrophy (MSA), a rare and serious neurological disorder. The trial will enroll 5 patients to check the treatm…

This is the first study in people to test the safety and side effects of an experimental drug called ION464 for multiple system atrophy (MSA), a rare and serious brain disorder. About 40 adults with MSA will receive the drug or a placebo via a spinal injection to see how their bo…

This study is testing whether an oral medication called TEV-56286 can help slow the progression of multiple system atrophy (MSA), a rare and serious neurological disorder. The trial will involve 350 adults with MSA across eight countries, who will take either the drug or a placeb…

This study is testing a new oral medication called YA-101 for people with multiple system atrophy (MSA), a rare and progressive brain disorder. It aims to find a safe and effective dose and see if the drug can help slow down the worsening of symptoms like walking difficulty and m…

This study is testing if applying gentle, controlled heat to the abdomen at night can safely lower high blood pressure in people with autonomic failure, a rare nerve disorder. Researchers will compare the effects of real heat versus a sham (fake) treatment in 20 participants. The…

This study is testing whether artificial intelligence (AI) can help doctors diagnose Parkinson's disease and similar conditions by analyzing videos of facial expressions and recordings of speech. Researchers will enroll 720 people, including those with Parkinson's, related disord…

This study aims to develop better tools for diagnosing Parkinson's disease and similar movement disorders. Researchers will use advanced brain scans and artificial intelligence to identify patterns that can distinguish between different conditions and predict how quickly they mig…

This study compares two common treatments for low blood pressure when standing up in people with autonomic nervous system disorders. Researchers will test whether a medication called midodrine or wearing an abdominal compression binder works better to improve blood flow and reduc…

This study is testing a new inflatable belt worn around the abdomen to see if it safely helps people with autonomic failure stand up without getting dizzy or fainting. Researchers will compare the real belt to a 'sham' belt with very low pressure in about 31 participants. The goa…

This study is testing if a CPAP machine, commonly used for sleep apnea, can help people with autonomic failure. These patients often have dangerously high blood pressure when lying down and severe dizziness when standing up. Researchers want to see if using CPAP at night can safe…

This study is testing a new type of brain scan to see if it can detect clumps of a specific protein linked to Parkinson's disease, Lewy body dementia, and multiple system atrophy. Researchers will give participants a small amount of a radioactive tracer and then perform a PET/MRI…

This study uses a special brain scan to measure dopamine activity in people with autonomic failure conditions like Parkinson's disease, multiple system atrophy, and Lewy body dementia. Researchers want to see if these scans can detect early changes that might predict which patien…

This study aims to understand how two existing medications, midodrine and droxidopa, affect blood flow in the abdomen of people with autonomic failure, a rare nerve disorder that causes severe drops in blood pressure when standing. Researchers will compare the drugs' effects on 3…

This study aims to build a detailed picture of Parkinson's disease and a related condition called Multiple System Atrophy. Researchers will follow 700 patients in Shanghai over time, collecting health data, brain scans, and biological samples. The goal is to find better ways to s…

This study aims to understand how a tight abdominal binder helps people with a nerve condition that causes severe drops in blood pressure when they stand up. Researchers will compare this physical therapy to a standard medication by measuring heart and blood flow changes while pa…

This study aims to understand the genetic causes of rare, progressive brain disorders like Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS), and Multiple System Atrophy (MSA). Researchers will collect DNA from up to 1,000 affected adults and their family members …

This study aims to better understand how two rare, progressive brain diseases—Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP)—damage the brain's nerve connections. Researchers will use specialized brain scans (PET and MRI) on about 36 participants to measur…