MULTIPLE SYSTEM ATROPHY

This early-phase study tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The goal was to see if the vaccine is safe and helps the body make antibodies against a harmful protein linked to these brain diseases. The study focused on safe…

This completed study tested a new PET imaging agent, [18F]-FD17, to detect abnormal alpha-synuclein protein clumps in the brain. Researchers scanned 55 people, including healthy volunteers and patients with Parkinson's disease, multiple system atrophy, or REM sleep behavior disor…

This study tested a special inflatable belt worn around the belly that automatically tightens to help raise blood pressure when standing. It included 28 adults aged 40-80 with autonomic failure and disabling low blood pressure upon standing. The goal was to see if the device safe…

This study tested a drug called droxidopa (L-threo DOPS) to see if it could reduce symptoms of orthostatic hypotension—dizziness and fainting when standing up—in people with multiple system atrophy (MSA). Over 100 adults with MSA took either the drug or a placebo for 12 weeks. Th…

This study looked at how squeezing the belly with a special band helps people with a condition that causes blood pressure to drop when they stand up. 21 adults with autonomic failure participated. The goal was to understand why this simple method works, comparing it to a standard…

This study looked at how two common treatments for low blood pressure upon standing—a medication called midodrine and an abdominal compression binder—affect heart health markers. Researchers measured things like pulse wave velocity and central blood pressure in 31 adults with aut…

This study looked at why people with multiple system atrophy (MSA) often feel pain. Researchers measured pain thresholds in 42 participants, including MSA patients, Parkinson's disease patients, and healthy volunteers. They used heat stimulation and reflex tests to see if levodop…

This study tested whether a 12-month educational program is practical for people with Multiple System Atrophy (MSA) and their caregivers. The program included in-person visits and online activities to help them understand symptoms and cope. Only 15 patient-caregiver pairs took pa…