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New drug TAK-341 tested in rare brain disease trial

NCT ID NCT05526391

Completed Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tested whether TAK-341, given as an IV infusion every 4 weeks for a year, can slow the progression of multiple system atrophy (MSA), a rare and serious brain disorder. The study enrolled 158 adults with MSA across North America, Europe, and Asia. Researchers measured changes in symptoms like movement and autonomic function using a standard rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

TAK-341 (a monoclonal antibody given by IV infusion)

What this could lead to

If it works, this could point toward a treatment that slows progression of multiple system atrophy, a rare and devastating neurological disease.

What could go wrong

This is a mid-stage trial with only 158 participants, so results may not apply to everyone. The drug may not show meaningful benefit over placebo, and IV infusions carry risks like infusion reactions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SYSTEM ATROPHY

Contacts and locations

Locations

  • Aarhus Universitetshospital

    Aarhus N, 8200, Denmark

  • Azienda Ospedale Universita Padova

    Padova, Veneto, 35126, Italy

  • Azienda Ospedaliera Universitaria OO.RR. San Giovanni di Dio Ruggi dAragona

    Salerno, 84131, Italy

  • Bispebjerg Hospital

    København NV, Capital, 2400, Denmark

  • Campus Neurologico Senior

    Loures, Lisbon District, 2674-514, Portugal

  • Charite - Universitatsmedizin Berlin

    Berlin, 10117, Germany

  • Chiba University Hospital

    Chuo-ku, Chiba, 260-8677, Japan

  • Deutsches Zentrum fur Neurodegenerative Erkrankung

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Duke University School of Medicine

    Durham, North Carolina, 27705-4410, United States

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan, Lombardy, 20122, Italy

  • Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo Besta

    Milan, Lombardy, 20133, Italy

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-8638, Japan

  • Hopitaux de La Timone

    Marseille, Bouches-du-Rhone, 13385, France

  • Hospital Pedro Hispano

    Senhora da Hora, Porto District, 4464-513, Portugal

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario Cruces

    Barakaldo, Vizcaya, 48903, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • IRCCS San Raffaele Roma

    Rome, Lazio, 00163, Italy

  • Inland Northwest Research

    Spokane, Washington, 99202-1342, United States

  • Istituto Clinico Humanitas

    Rozzano, Lombardy, 20089, Italy

  • Klinikum Groshadern, LMU

    München, Bavaria, 81377, Germany

  • Kyoto University Hospital

    Kyoto, Kyoto, 606-8507, Japan

  • Mayo Clinic

    Rochester, Minnesota, 55905-0001, United States

  • Medical Hospital of Tokyo Medical and Dental University

    Bunkyo-Ku, Tokyo, 113-8519, Japan

  • Medizinische Hochschule Hannover

    Hanover, Lower Saxony, 30625, Germany

  • Medizinische Universitat Graz

    Graz, Styria, 8036, Austria

  • NYU Langone Health

    New York, New York, 10016-6402, United States

  • National Center of Neurology and Psychiatry

    Kodaira-Shi, Tokyo, 187-8551, Japan

  • Paracelsus-Elena-Klinik Kassel

    Kassel, Hesse, 34128, Germany

  • Quest Research Institute - Alcanza - HyperCore

    Farmington Hills, Michigan, 48025, United States

  • Southampton General Hospital

    Southampton, Hampshire, SO16 6YD, United Kingdom

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • The University of Tokyo Hospital

    Bunkyo-Ku, Tokyo, 113-0033, Japan

  • Universitaetsklinikum der Ruhr-Universitaet Bochum (UKRUB) - St. Josef-Hospital

    Bochum, North Rhine-Westphalia, 44791, Germany

  • Universitatsklinikum Carl Gustav Carus an der TU Dresden

    Dresden, Saxony, 01307, Germany

  • Universitatsklinikum Leipzig

    Leipzig, Saxony, 04103, Germany

  • Universitatsklinikum Munster

    Münster, North Rhine-Westphalia, 48149, Germany

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390-7208, United States