MULTIPLE SYSTEM ATROPHY

This is a very early-stage safety study testing a new gene therapy for multiple system atrophy (MSA), a rare and progressive brain disorder. The therapy, called AAV2-GDNF, is delivered directly into a part of the brain called the putamen. The main goal is to see if the treatment …

This study is testing an investigational drug called Lu AF82422 to see if it can slow down the progression of multiple system atrophy (MSA), a rare and serious brain disorder. About 64 participants with MSA will receive either the drug or a placebo for nearly a year to compare th…

This expanded access program is testing whether stem cell injections can help control multiple system atrophy (MSA), a rare and progressive brain disorder. Up to 7 adults with confirmed MSA will receive monthly IV infusions and spinal injections of donor stem cells over 44 weeks.…

This study is testing whether stem cells taken from a patient's own fat tissue and injected into their spinal fluid can slow the progression of multiple system atrophy (MSA), a rare and fatal neurological disease. Researchers are comparing two different dosing schedules against a…

This large, late-stage trial is testing whether a new drug called amlenetug can slow down the progression of multiple system atrophy (MSA), a rare and serious brain disorder. About 357 people with MSA will receive either the drug or a placebo via monthly IV infusions for over a y…

This study is testing the safety and how the body processes a new drug called exidavnemab in people with mild to moderate Parkinson's disease or multiple system atrophy. About 38 participants will receive either the drug or a placebo to see how well it is tolerated. The main goal…

This study is testing whether online training for community neurologists and telemedicine support services for patients and their caregivers can improve quality of life. It focuses on people with Parkinson's disease, Lewy Body Dementia, and related conditions, along with their ca…

This study aims to improve the tests used to diagnose chronic autonomic failure, a condition where the body's automatic functions like blood pressure control stop working properly. Researchers will enroll about 89 adults with conditions like Parkinson's disease, multiple system a…

This study aims to better understand how early Parkinson's disease and a related condition called multiple system atrophy progress over time. Researchers will follow 150 participants for 18 months, tracking their symptoms, movement abilities, and quality of life. The goal is to g…

This study aims to better understand how Multiple System Atrophy (MSA) progresses over time. Researchers will follow 90 patients in China and Europe, tracking their symptoms and using MRI scans and blood tests to look for biological markers of the disease. The goal is to gather d…

This study aims to understand how blood flow in abdominal veins contributes to blood pressure problems in people with Multiple System Atrophy, a rare nervous system disorder. Researchers will study about 16 participants with both low blood pressure when standing and high blood pr…