Hope for rare brain disease: new drug aims to slow MSA
NCT ID NCT05104476
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called Lu AF82422 in 64 people with multiple system atrophy (MSA), a rare and serious brain disease. The goal is to see if the drug can slow down the worsening of symptoms like movement problems and daily living difficulties. Participants receive either the drug or a placebo, and the study measures changes over time using a standard rating scale.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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CenExel Rocky Mountain Clinical Research, LLC
Englewood, Colorado, 80113, United States
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Columbia University Medical Center - The Neurological Institute of New York
New York, New York, 10032, United States
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Endeavor Health - Glenbrook Hospital
Glenview, Illinois, 60026, United States
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Fujita Health University Hospital
Toyoake, Aichi-ken, 470-1192, Japan
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Gifu University Hospital
Gifu, Gifu, 501-1194, Japan
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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NYU Langone Health Medical Center
New York, New York, 10016, United States
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National Hospital Organization Sendai Nishitaga Hospital
Sendai, Miyagi, 982-8555, Japan
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Parkinson's Disease And Movement Disorder Center Of Boca Raton
Boca Raton, Florida, 33486, United States
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Penn State Milton S. Hershey Medical Center - Penn State Hershey Neuroscience Institute (PSHNI)
Hershey, Pennsylvania, 17033, United States
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Rush University Medical Center, Rush University Cancer Center
Chicago, Illinois, 60612, United States
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The Parkinsons and Movement Disorder Institute
Fountain Valley, California, 92708, United States
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University Nebraska Medical Center
Omaha, Nebraska, 68198-8440, United States
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University Of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
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University of California - San Diego
La Jolla, California, 92037, United States
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University of California, San Francisco Neurosciences Clinical Research Unit
San Francisco, California, 94158, United States
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University of Florida Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, 32608, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19107, United States
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