MULTIPLE SYSTEM ATROPHY

This early study tests if implanting a small piece of the participant's own leg nerve into a key brain area is safe and feasible for people with early Parkinson's disease or Multiple System Atrophy (MSA). Seven people will take part; four will get the nerve graft and three will h…

This study tests an experimental pill called TEV-56286 for people with multiple system atrophy (MSA), a rare brain disorder that affects movement and body functions. About 350 adults will receive either the drug or a placebo for 48 weeks. The goal is to see if the drug can slow t…

This study tests a new oral drug, TEV-56286, in 200 adults with Multiple System Atrophy (MSA), a rare and serious brain disorder. The main goal is to see if the drug is safe and tolerable over about 100 weeks. Participants must have completed a prior related study. This is not a …

This study tests a new drug, YA-101, in 75 people with multiple system atrophy (MSA), a rare brain disease that affects movement and body functions. The trial is double-blind and placebo-controlled, meaning some participants get the drug and some get a placebo, and neither they n…

This program provides the experimental drug ATH434 to people with multiple system atrophy (MSA) who finished earlier Phase 2 studies. The goal is to allow continued treatment for those who may benefit, as judged by their doctor. Participants take the drug by mouth twice daily.

This early study tests a nasal spray called foralumab in 5 adults with Multiple System Atrophy (MSA), a rare brain disease that gets worse over time. The goal is to see if the drug can calm overactive immune cells in the brain and slow down the disease. Participants will be monit…

This early-stage study tests an experimental drug called ION464 in 40 adults with multiple system atrophy (MSA), a rare and serious brain disorder. The main goal is to check the drug's safety and how well people tolerate it when given via a spinal injection. Researchers will also…

This study provides expanded access to an experimental stem cell treatment called HB-adMSCs for up to 7 adults with Multiple System Atrophy (MSA), a rare and serious brain disorder. Participants will receive 12 intravenous infusions and 6 spinal injections over 44 weeks. The goal…

This study uses artificial intelligence to analyze facial expressions and speech patterns in people with Parkinson's disease and related conditions. The goal is to create a simple, non-invasive digital tool that can help doctors diagnose and track these diseases more accurately. …

This study looks at whether using a CPAP machine (commonly used for sleep apnea) can lower high blood pressure when lying down at night and help with dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like Parkinson's disease or m…

This study tests whether applying gentle heat to the belly overnight can safely lower high blood pressure in people with autonomic failure who also have high blood pressure when lying down. About 20 adults with conditions like Parkinson's or Multiple System Atrophy will be monito…

This study tests whether a personalized form of transcranial magnetic stimulation (rTMS) can improve movement and non-movement symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty adults aged 30-80 will receive 10 daily se…

This study tests a comprehensive swallowing rehabilitation program for people with multiple system atrophy (MSA) who have trouble swallowing. Researchers want to see if the therapy can reduce the risk of food or liquid entering the airway and improve quality of life. The study wi…

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…

This study looks at how two medications, midodrine and droxidopa, affect the veins in the abdomen of people with autonomic failure—a condition where the body can't control blood pressure properly. Researchers will measure changes in heart function when participants are tilted upr…

This study is following 2950 people, including healthy individuals and those with memory or movement problems, to learn more about brain diseases like Alzheimer's and Parkinson's. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve di…

This study uses special brain scans to look at damage to nerve cell connections (synapses) in people with two rare brain diseases: Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP). About 36 adults aged 45-80 will be scanned over a year to track how the disea…

This study is observing 280 people with Parkinson's disease or multiple system atrophy to understand how pain and automatic body functions (like sweating, digestion, and heart rate) affect their daily lives. Researchers will track symptoms before and after a rehabilitation progra…

This study is looking for ways to improve how doctors diagnose Parkinson's disease and similar conditions like multiple system atrophy and progressive supranuclear palsy. Researchers will use brain scans and artificial intelligence to find patterns that can tell these diseases ap…

This study aims to collect DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, as well as their family members. Researchers will use blood samples to perform whole genome sequenc…

This study is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of a protein called alpha-synuclein in the brain using PET scans. Researchers will scan 40 people, including those with Parkinson's disease, multiple system atrophy, dementia with Lewy …

This study is creating a detailed database of 600 people with Parkinson's disease and 100 with multiple system atrophy in Shanghai. Participants will provide medical history, undergo tests (like brain scans and memory assessments), and give blood samples. Researchers will track t…