DNA hunt for rare brain disease genes begins

NCT ID NCT06647641

Recruiting now Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study collects DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, plus their family members. Researchers will sequence participants' whole genomes to find genetic variants linked to these diseases. The goal is to better understand the genetic roots of these rare neurological disorders.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could identify new genetic markers linked to these rare brain diseases, paving the way for future treatments.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and findings may take years to translate into therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CORTICOBASAL DEGENERATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Corticobasal Degeneration corticobasal degeneration disorder corticobasal syndrome familial spontaneous pneumothorax multiple system atrophy Multiple system atrophy (MSA) with orthostatic hypotension multiple system atrophy, cerebellar type multiple system atrophy, parkinsonian type myopathy, lactic acidosis, and sideroblastic anemia progressive supranuclear palsy Shy-Drager Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORTICOBASAL DEGENERATION CORTICOBASAL DEGENERATION (CBD) CORTICOBASAL DEGENERATION SYNDROME CORTICOBASAL SYNDROME CORTICOBASAL SYNDROME (CBS) MSA MSA - MULTIPLE SYSTEM ATROPHY MSA-C MULTIPLE SYSTEM ATROPHY MULTIPLE SYSTEM ATROPHY (MSA) WITH ORTHOSTATIC HYPOTENSION MULTIPLE SYSTEM ATROPHY - CEREBELLAR SUBTYPE (MSA-C) MULTIPLE SYSTEM ATROPHY - PARKINSONIAN SUBTYPE (MSA-P) MULTIPLE SYSTEM ATROPHY, CEREBELLAR TYPE MULTIPLE SYSTEM ATROPHY, PARKINSONIAN TYPE PROGRESSIVE SUPRANUCLEAR PALSY PROGRESSIVE SUPRANUCLEAR PALSY(PSP) PSP PSP - PROGRESSIVE SUPRANUCLEAR PALSY

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.