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New drug YA-101 aims to slow rare brain disease

NCT ID NCT06848231

Recruiting now Disease control Sponsor: Dasher Neuroscience Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests the safety and effectiveness of YA-101, an oral drug, in 75 people with multiple system atrophy (MSA), a rare and progressive brain disorder. Participants will receive either YA-101 or a placebo twice daily for several weeks. The study will monitor side effects and measure drug levels in the blood to see if YA-101 can help control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
YA-101
What this could lead to
If it works, this could point toward a treatment that slows or controls multiple system atrophy, a rare and devastating brain disease.
What could go wrong
This is an early Phase 2 trial with only 75 participants, so results may not apply to everyone. The drug may not work or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SYSTEM ATROPHY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Baylor College of Medicine

    RECRUITING

    Houston, Texas, 77030, United States

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Email: •••••@•••••

  • Columbia University Irving medical center

    RECRUITING

    New York, New York, 10032, United States

  • Juntendo University Hospital

    RECRUITING

    Tokyo, Japan

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100225, Taiwan

  • National Taiwan University Hospital Cancer Center

    NOT_YET_RECRUITING

    Taipei, 106, Taiwan

  • UCLA Health

    RECRUITING

    Los Angeles, California, 90095, United States

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

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