Sound waves vs. Parkinson's: can ultrasound calm tremors and stiffness?

NCT ID NCT07764874

Not yet recruiting Disease control Sponsor: InSightec Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests a non-surgical treatment for advanced Parkinson's disease that uses focused ultrasound to create a tiny lesion in a brain pathway linked to motor symptoms. It compares treating one side of the brain versus both sides, against standard medication. The goal is to see if this approach can reduce tremors, stiffness, and medication-related complications, improving daily movement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MR-guided focused ultrasound (Exablate Neuro System) to create a small lesion in the brain's pallidothalamic tract, without surgery
What this could lead to: If successful, this could offer a non-surgical option to reduce disabling motor symptoms and medication complications in advanced Parkinson's disease, potentially improving daily function.
What could go wrong: The treatment involves creating a brain lesion, which carries risks like bleeding, swelling, or neurological deficits. It's an early-stage trial, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

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Other studies related to the condition(s) this trial covers.