PARKINSON DISEASE

This study checks the long-term safety and lasting effects of a gene therapy called IPS101A in 6 people with severe Parkinson's disease who already received it in an earlier trial. Researchers will monitor side effects and measure changes in movement symptoms over time. The goal …

This Phase 2 trial tests an oral drug called NEU-411 in 150 adults aged 40-80 with early Parkinson's disease who have a specific genetic marker (LRRK2-driven). The study is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets the real drug. Rese…

This Phase 2 study tests whether a single dose of AAV2-GDNF gene therapy, delivered directly into the brain, can improve motor function in adults with moderate Parkinson's disease. About 127 participants will receive either the gene therapy or a sham surgery. The main goal is to …

This study investigates whether a wrist-worn sensor (KinesiaU) can accurately measure how long people with Parkinson's disease experience 'good on-time' — periods when medication works well and symptoms are controlled without troublesome movements. Researchers are testing IPX-203…

This phase 2 trial tests whether dapansutrile, a drug that targets inflammation, is safe and can reduce brain and body inflammation in people with early Parkinson's disease. 36 participants will take either the drug or a placebo daily for 6 months, with brain scans and spinal tap…

This phase 2 trial is testing whether a nasal spray containing insulin and glutathione can safely improve symptoms in people with Parkinson's disease. About 56 participants will receive either the active spray or a placebo, added to their usual medications. The study focuses on c…

This study follows 270 Italian adults with advanced Parkinson's disease who are already prescribed Foslevodopa/Foscarbidopa, a drug given as a continuous infusion under the skin. Researchers will track how the drug affects quality of life over 12 months using a standard questionn…

This early-phase trial tests a new treatment called NouvNeu001 for people with advanced Parkinson's disease. It involves injecting special brain cells directly into areas of the brain that control movement. The study will enroll just 5 participants to see if the procedure is safe…

This early-stage trial tests a gene therapy called IPS101A in 6 people with advanced Parkinson's disease (stages 4-5) whose symptoms are not controlled by current medications. The main goal is to check safety and find the best dose. Researchers will also look for any signs that t…

This early-stage trial is testing an experimental drug called LY4006896 in healthy volunteers and people with Parkinson's disease. The main goal is to check if the drug is safe and how the body processes it. Researchers will give single or multiple doses and watch for side effect…

This early-stage trial tests an experimental oral drug called HL-400 in 86 healthy volunteers. The drug aims to block a protein (NLRP3) linked to inflammation, which may play a role in Parkinson's disease. The study focuses on safety, tolerability, and how the drug moves through …

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started Parkinson's medication will be assigned to either moderate or high-intensity treadmill ses…

This program offers continued free access to the experimental drug BIA 28-6156 for people with Parkinson's disease who have a specific change in the GBA1 gene and have already completed the ACTIVATE study. Participants take one 60mg pill daily. The goal is to provide ongoing trea…

This study tests whether etoricoxib, an anti-inflammatory drug, can help control symptoms in people with Parkinson's disease when added to their usual treatment. The trial will include 60 adults with Parkinson's and measure changes in movement and daily function. The goal is to s…

This study tests whether varenicline (Chantix), a drug used to help people quit smoking, can reduce falls in people with Parkinson's disease. About 102 participants will take either varenicline or a placebo for one year. Researchers will measure changes in walking speed while mul…

This early-stage trial tests if transplanting a patient's own stem cells into the brain is safe for Parkinson's disease. Researchers take skin cells, turn them into dopamine-producing brain cells, and surgically place them in the brain. Only 8 people with moderate Parkinson's wil…

This study is testing whether montelukast, a common asthma medication, can help control symptoms of Parkinson's disease. Researchers will enroll 60 adults with Parkinson's who are already taking levodopa. The main goal is to see if montelukast improves movement and daily living s…

This early trial tests whether a surgically implanted device that stimulates a specific brain network (called SCAN) can improve movement problems in people with Parkinson's disease. Three adults with Parkinson's will receive the implant and be followed for 12 months. The study is…

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people at high risk. Participants with REM sleep behavior disorder or early Parkinson's will wear a headband and headphones for 18 months. Researchers will track ch…

This program allows eligible people with Parkinson's disease to receive tavapadon, an experimental oral tablet, before it is officially approved. A doctor must decide if the potential benefit outweighs the risks. The program is only available in certain territories and for those …

This study tests whether exercising more frequently (5 times a week for one month, then three weeks off) is better than exercising once a week with no breaks for people with moderate Parkinson's disease. The exercise is a partnered dance program based on Argentine tango, adapted …

This study tests whether a daily pill called BHV-8000 can slow the worsening of motor skills in people recently diagnosed with Parkinson's disease. About 550 adults aged 40 to 85 with early Parkinson's will receive either BHV-8000 (10 mg or 20 mg) or a placebo for up to 48 weeks.…

This international study is following 1,000 people who already have or are getting an Abbott deep brain stimulation (DBS) system to treat Parkinson's disease, essential tremor, or dystonia. Researchers will track how well the device controls symptoms and monitor for serious side …

This study compares deep brain stimulation (DBS) plus medication against medication alone for Parkinson's patients who also have impulse control disorders, like gambling or compulsive behaviors. About 60 participants aged 70 or younger will be randomly assigned to one of the two …

This study looks at whether a 12-month home exercise program can improve thinking skills in people with Parkinson's disease who also have mild memory or attention problems. Researchers will compare exercisers to a sedentary group and measure changes in movement, mood, and blood m…

This study tests whether vinpocetine, a drug thought to improve blood flow in the brain, can safely reduce Parkinson's symptoms like tremor and stiffness. Researchers will enroll 60 adults with Parkinson's who already take levodopa. The goal is to see if adding vinpocetine leads …

This study tests whether metformin, a standard diabetes medication, can safely improve movement and quality of life in people with Parkinson's disease. Researchers will enroll 60 adults aged 50 and older who are already taking levodopa/carbidopa. The main goal is to see if metfor…

This study tests whether a supplement called tributyrin can improve memory, thinking, and walking in people with Parkinson's disease who also have cognitive problems. 45 participants will take either tributyrin or a placebo three times daily for about 90 days. Researchers will me…

This study looks at how genetics and aerobic exercise together might slow the progression of Parkinson's disease. Two hundred people with Parkinson's will take part in a community-based cycling program three times a week for a year. Researchers will track motor symptoms and think…

This Phase 2 trial is testing whether silymarin, an antioxidant from milk thistle, can protect brain cells and improve symptoms in people with Parkinson's disease. Researchers will give 50 adults either silymarin or a placebo alongside their usual Parkinson's medications. The goa…

This early-phase study tests a new radioactive tracer called [¹⁸F]MODAG-009 to see if it can safely highlight abnormal protein clumps in the brains of people with Parkinson's disease or multiple system atrophy (MSA). About 13 participants, including healthy volunteers, will recei…

This study is testing a non-invasive eye camera that takes pictures of the retina using different colors of light. Researchers want to see if these images can help detect signs of Alzheimer's, Parkinson's, and other neurodegenerative diseases. About 930 adults over age 30 with or…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This study is testing a new blood test to help doctors diagnose Parkinson's disease and similar brain disorders more accurately and earlier. Researchers will use a technique called RT-QuIC to detect misfolded proteins in blood samples from 458 participants, including healthy peop…

This study looks at whether a protein linked to Parkinson's disease can be found in colon tissue samples taken during a routine colonoscopy. Researchers will compare samples from people with Parkinson's, those with REM sleep behavior disorder, and healthy individuals. The goal is…

This study tests whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers look for a protein called alpha-synuclein in the colon of people already diagnosed with Parkinson's. If successful, this could lead to earlier detection a…

This phase 3 study is testing an improved PET/CT imaging method using a radioactive tracer called 18F-DOPA. Researchers want to see if it can better detect small lesions and reduce image artifacts in patients with conditions like congenital hyperinsulinism, neuroblastoma, neuroen…

This study is testing three new radioactive tracers that light up alpha-synuclein clumps in the brain during PET/CT scans. Researchers want to see if these scans can accurately diagnose Parkinson's disease and related disorders. 500 adults with suspected or confirmed Parkinson's …

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This early-phase study tests a new radioactive tracer called 11C-HY-2-15, designed to detect abnormal alpha-synuclein protein in the brain. Researchers will scan 70 adults with multiple system atrophy, Parkinson's disease, progressive supranuclear palsy, or healthy volunteers to …

This study aims to develop computer models that can help diagnose and monitor Parkinson's disease by analyzing eye movements and walking patterns. Researchers will collect data from 100 people with Parkinson's or similar conditions using special devices. The goal is to make diagn…

This study is testing a smartphone app that records and analyzes speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

This study tests whether increasing physical activity through a motivational smartphone app can slow cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease and related disorders. Researchers will enroll 130 participants …

This pilot study tests whether a single session of breathing air with slightly higher carbon dioxide and lower oxygen can improve speech, cough, and movement in people with Parkinson's disease. Participants are randomly assigned to one of two breathing patterns, each lasting abou…

This study tests whether a non-invasive brain stimulation technique called TMS can help with apathy—a common lack of motivation—in people with Parkinson's disease. Sixty participants will receive TMS to two different brain areas on separate visits and perform a task where they ch…

This study tests whether walking with a metronome at different speeds can improve how people with Parkinson disease walk. 45 participants will do 12 training sessions on a treadmill and overground, using slow and fast beats to encourage larger and faster steps. Researchers will m…

This study tests whether a 3-week cane training program can improve walking speed and confidence in people with Parkinson's disease. 26 participants will either receive cane training or do stretching exercises. The goal is to see if using a cane properly helps with gait and reduc…

This study tests whether a program of supervised eye exercises can improve physical function, balance, and reduce fear of falling in people with Parkinson's disease. 34 participants will do progressive eye movements and gaze stabilization exercises in a clinic setting. The goal i…

This early study tests whether a spinal cord stimulation device called ARC-IM can safely improve walking and balance in people with Parkinson's disease. Six participants will receive the therapy, and researchers will monitor side effects and measure changes in gait speed and endu…

This study tests whether a single dose of psilocybin, given with psychological support, can improve depression in people with Parkinson's disease. Sixty adults aged 40 to 80 with mild to moderate Parkinson's and depressive symptoms will receive either a low or high dose of psiloc…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study tests a software called CereGate that fine-tunes an already-implanted deep brain stimulator to reduce freezing of gait in Parkinson's disease. About 41 participants will have their stimulator adjusted using the software. The goal is to see if this extra tuning can make…

This study tests a robot-guided exercise program for people with mild to moderate Parkinson's disease. Participants will do exercises three times a week for three weeks, either in person or remotely. The goal is to see if the program is safe, doable, and helps improve movement an…

This study tests whether a 4-week virtual balance training program, guided by a physical therapist and monitored with wearable sensors, can improve balance and reduce fall risk in older adults with Parkinson's disease. Eighty participants aged 55-85 will complete 12 remote sessio…

This small pilot study tests whether a special rocking bed (Somnomat Casa) can improve sleep quality in people with Parkinson's disease. Fifteen participants will use the bed at home for two months, and researchers will measure how acceptable and helpful the treatment is. The goa…

This study is testing whether speech amplification devices can help people with Parkinson's disease and related conditions who have a soft, weak voice (hypophonia). Researchers will work with 100 participants to measure how well these devices improve speech loudness, clarity, and…

This phase 2a trial tests an oral liquid containing low-dose carbon monoxide (HBI-002) in 36 people with Parkinson's disease. Participants take it daily for 14 days to see if it is safe and tolerable. The study is randomized and placebo-controlled, meaning some get the drug and s…

This study tests a new device that uses focused ultrasound waves on the brain to see if it can safely improve movement problems in people with Parkinson's disease. About 60 adults with Parkinson's will receive either real or fake (sham) ultrasound treatments. Researchers will mea…

This study tests whether Parkinson's patients can improve their movement by watching personalized 3D virtual reality recordings of their own smooth, fast actions. 24 participants will use VR headsets to view their own best movement sequences, aiming to retrain the brain and reduc…

This study aims to improve walking and balance in people with Parkinson's disease who already have a brain implant (deep brain stimulation). Researchers will use MRI scans and computer models to find the best settings for each person's implant. Sixty participants will test these …

This study tests whether a daily probiotic supplement can help treat depression in people with Parkinson's disease. Sixty adults with mild to moderate Parkinson's and depression will take either the probiotic or a placebo for 12 weeks. Researchers will measure changes in mood and…

This study looks at how well the drug opicapone works for people with Parkinson's disease who have early signs of motor fluctuations (times when movement symptoms change). About 200 adults in Italy will take the drug as part of their normal care. Researchers will check if patient…

This study tests a new drug called CST-3056 in 12 adults with neurogenic orthostatic hypotension (a sharp drop in blood pressure when standing) caused by Parkinson's disease or pure autonomic failure. The goal is to see if the drug can improve blood pressure and reduce symptoms l…

This study tests whether rhythmic auditory stimulation (RAS) — listening to a metronome beat — can improve walking in people with Parkinson's disease who have a deep brain stimulator (DBS). Ten participants will walk to the beat for four minutes with their DBS turned on and off. …

This study tests whether a new type of deep brain stimulation (called patterned DBS) is safe and tolerable for people with Parkinson's disease to use at home. About 60 adults who already have a DBS device will try the new stimulation pattern for two weeks. The goal is to see if t…

This study tests a non-invasive brain stimulation method called temporal interference stimulation (TIS) to see if it can improve motor and speech problems in people with Parkinson's disease or secondary Parkinson's syndrome. Sixty participants will receive either real TIS or a sh…

This study tests whether a gentle electrical brain stimulation technique called tDCS can improve cognitive problems in people with Parkinson's disease who have mild memory or thinking issues. About 36 participants will receive the stimulation while their brain activity and cognit…

This study tests whether combining exercise video games (exergaming) with real-time brainwave feedback can improve balance in people with Parkinson's disease. One hundred participants will be randomly assigned to either exergaming alone or exergaming plus neurofeedback, training …

This small pilot study tests a special standing desk that gently moves, prompting people with Parkinson's to take small steps while standing. Five participants will use the desk for up to 12 sessions over 6 weeks. Researchers will measure walking speed, motor symptoms, and thinki…

This study is testing SL-APO (Kynmobi), a fast-acting film placed under the tongue, to treat OFF episodes in people with Parkinson's disease. OFF episodes are times when Parkinson's symptoms return between medication doses. The study will enroll 90 adults and observe how doctors …

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce impulse control disorders in people with Parkinson's disease who are on dopamine therapy. Twenty participants will receive both real and sham stimulation in random order, then complete task…

This study looks at whether combining physical exercise with a gentle, non-invasive brain stimulation technique (tDCS) can improve walking, balance, and reaction time in people with Parkinson's disease. Researchers will measure changes in movement speed and coordination in 100 pa…

This study tests an experimental drug called AP-472 in people with Parkinson's disease who have motor fluctuations—times when their usual levodopa medication stops working well. About 150 participants will take either a low dose, a high dose, or a placebo pill for 8 weeks, added …

This study looks at whether using a CPAP machine (a device that gently blows air through a mask) can safely lower high blood pressure when lying down at night and help reduce dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like…

This study tests whether a non-invasive brain stimulation technique called MRI-guided transcranial direct current stimulation (tDCS) can reduce depression and apathy in people with Parkinson's disease. Forty participants will receive either real or sham stimulation, and researche…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This study tests whether adding music-like sounds (sonification) to standard walking rehabilitation can improve gait, balance, and quality of life. 120 adults with Parkinson's disease, stroke, or multiple sclerosis will be randomly assigned to standard rehab or rehab with sonific…

This pilot study tests a personalized music therapy program to prevent delirium (sudden confusion) in hospitalized people with neurodegenerative diseases like Alzheimer's or Parkinson's. Thirty participants will receive up to five live music sessions tailored to their preferences…

This study tests whether doing high-intensity exercise before virtual reality training can improve balance and brain flexibility in people with Parkinson's disease. Sixteen participants will be split into two groups: one does intense exercise plus VR, the other does stretching pl…

This study tests a device that uses light, sound, and gentle touch to stimulate brain waves at a specific frequency (gamma). Researchers want to see if it is safe and can change brain activity in people with mild Parkinson's disease. 40 participants will use the device for 30-60 …

This study tests a new way to use deep brain stimulation (DBS) for Parkinson's disease. Standard DBS helps movement but can sometimes cause thinking or mood problems. The researchers will add low-frequency stimulation to a different part of the brain while keeping the usual high-…

This study tests whether a fast form of brain stimulation (called accelerated TMS) can help with apathy—a lack of motivation—in people with Parkinson's disease. Fifteen participants will receive 48 stimulation sessions over two weeks. Researchers will check if the treatment is sa…

This study tests whether a continuous apomorphine pump can reduce stiffness and improve comfort in Parkinson's patients who are near the end of life and can no longer take oral medications. Researchers will follow 80 patients receiving home hospital care, measuring symptoms like …

This study tests whether following a Mediterranean-style diet for 18 months is practical and beneficial for people with Parkinson's disease. Researchers will see if the diet is easy to stick with and if it leads to changes in gut bacteria or Parkinson's symptoms. About 40 partici…

This study explores whether listening to personally meaningful music can reduce apathy—a lack of motivation and emotion—in people with Parkinson's disease. Fifty participants will listen to their own chosen music or neutral podcasts for 8 weeks. Researchers will use brain scans a…

This study tests whether an online self-management program can help people with early-stage Parkinson's disease maintain their daily activities and quality of life as well as in-person task training. One hundred participants aged 45-70 will be split into three groups: online prog…

This study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum can improve cognitive deficits and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's…

This study tests a wearable device called Cue2Walk that automatically detects freezing of gait in people with Parkinson's disease and provides rhythmic cues to help them keep walking. The study will compare the device's effectiveness and cost against usual care in 84 participants…

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study looks at whether different types of exercise—like cardio, strength training, or a mix—can help people with Parkinson's disease sleep better. Researchers will track sleep quality and brain activity during sleep in 150 participants over 12 weeks. The goal is to find whic…

This study is testing whether a non-invasive device that sends mild electrical pulses to the spinal cord can improve walking and balance in people with Parkinson's disease. The device is placed on the skin, so no surgery is needed. Twenty adults with Parkinson's who can walk at l…

This study tests whether functional rotational exercises can lower fall risk and improve mobility and balance in people with Parkinson's disease. Researchers will enroll 50 adults aged 50-70 with mild to moderate Parkinson's. Participants will perform rotational exercises, and th…

This study tests whether pyridostigmine, a drug that stimulates the gut, can safely relieve chronic constipation in people with Parkinson's disease. Constipation is a common and bothersome symptom that often appears years before movement problems. Sixteen adults with Parkinson's …

This study tests whether electrical spinal cord stimulation is safe for people with Parkinson's disease who have a painful, bent-forward posture called camptocormia. Six participants will receive the stimulation and be monitored for side effects for about 10-11 months. The goal i…

This study tests whether a non-invasive brain stimulation technique called patterned repetitive transcranial magnetic stimulation (prTMS) can reduce bradykinesia—slowness of movement—in people with Parkinson's disease. Researchers will apply the stimulation over a brain area invo…

This study tests whether supervised pool exercises (aquatic therapy) can improve daily activities, walking, balance, posture, pain, and mood in people with Parkinson's disease. 42 participants will either do home exercises alone or add three 45-minute pool sessions per week for s…

This study tests whether adding visual feedback exercises—using a laser pointer—to standard physical therapy can improve balance and mobility in people with Parkinson's disease. 32 participants will be randomly assigned to either standard exercises alone or standard exercises plu…

This study looks at whether changing the ratio of carbidopa to levodopa in standard Parkinson's medication can reduce orthostatic hypotension—a sudden drop in blood pressure when standing that causes dizziness and fainting. Researchers will give 36 patients with Parkinson's disea…

This study compares two ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease: adaptive DBS, which adjusts stimulation in real time based on brain signals, and continuous DBS, which delivers constant stimulation. About 130 adults who already have a DB…

This study is testing whether fexofenadine, a common allergy medication, can improve quality of life for people with Parkinson's disease who are already on standard treatment. Researchers will enroll 46 adults aged 50 and older with mild to moderate Parkinson's. The main goal is …

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime hypertensi…

This study tests a wearable sensor that tracks neck muscle activity during swallowing exercises, providing real-time feedback to patients. Researchers want to see if adding this device to standard therapy improves swallowing more than therapy alone. The study includes 120 adults …

This study tests a digital system called NMS Assist that helps people with Parkinson's and their care partners track non-motor symptoms like pain, sleep problems, and mood changes. 30 participants will use the system for 6 months, and researchers will see if it's easy to use and …

This study tests whether a non-invasive brain stimulation technique called tDCS, applied while people walk, can improve motor skills like gait, speech, and eye movements. Twenty adults with progressive supranuclear palsy, corticobasal degeneration, or Parkinson's disease will rec…

This study is testing whether changing the strength of deep brain stimulation (DBS) during sleep can help people with Parkinson's disease sleep better. Ten participants will try three different nighttime DBS settings (off, half strength, and full strength) for two weeks each. The…

This study tests a wearable device that provides gentle vibrations timed to each step, aiming to make walking more automatic for people with Parkinson's disease. Sixty participants will be randomly assigned to receive either personalized step-synchronized cues or fixed-interval c…

This study tests whether a new type of deep brain stimulation that adapts in real time to brain activity can safely improve walking and balance problems in people with Parkinson's disease. Ten participants who already have a compatible brain implant will be enrolled. The goal is …

This study tests whether celecoxib, an anti-inflammatory drug, can help people with Parkinson's disease. Researchers believe brain inflammation plays a role in Parkinson's, and celecoxib may reduce that inflammation. The trial will include 80 adults with Parkinson's and measure c…

This study tests whether following a Mediterranean diet for three months after deep brain stimulation surgery helps Parkinson's patients control weight gain and improve body composition. Researchers will compare a diet group to a usual-diet group using weight, appetite, and quali…

This study tests whether adding gentle electrical stimulation to the brain and spine can improve walking and balance training for people with Parkinson's disease who have trouble with gait. About 71 participants (51 with Parkinson's and 20 healthy controls) will take part. The Pa…

This study tests whether turning on an extra deep brain stimulation (DBS) electrode in a brain region called the globus pallidus externa (GPe) can help people with Parkinson's disease who have severe insomnia. Ten participants aged 40-80 will report changes in their sleep quality…

This study tests whether real-time visual feedback from the SpiroGym app helps people with Parkinson's disease perform breathing muscle exercises more effectively. Thirty participants will do the exercises with and without the app's feedback, and researchers will measure muscle a…

This study tests whether a newer 'directional' brain stimulation method works better than the standard 'ring' method for people with Parkinson's disease. Ten participants who already have deep brain stimulation electrodes implanted will try both modes. The goal is to see which on…

This study is testing a smartphone app called MindTrails-Movement to see if it can help reduce anxiety in people with Huntington's or Parkinson's disease. The app uses a technique called cognitive bias modification for interpretation (CBM-I) to train users to think less negativel…

This study tests whether a temporary spinal cord stimulator can help people with advanced Parkinson's disease who experience freezing of gait—a sudden inability to move their feet—that doesn't respond to medication. Five participants will receive the device, which delivers mild e…

This study tests whether high-frequency repetitive transcranial magnetic stimulation (rTMS) can improve balance in people with Parkinson's disease. Forty participants with mild to moderate Parkinson's will receive 12 sessions over four weeks. Researchers will measure changes in s…

This study tests a non-invasive device that stimulates the vagus nerve in the ear, timed with breathing, to see if it can reduce apathy (lack of motivation) in people with Parkinson's disease. 60 participants will receive either the real stimulation or a sham (fake) version for 2…

This study follows 120 people with Parkinson's disease who are using a continuous apomorphine infusion pump (ONAPGO™) to see how it works in real-world settings. Researchers will track how long it takes to find the right dose, any changes to other Parkinson's medications, and how…

This study tests a remote coaching program to help people with Parkinson's disease in Qatar exercise more. 40 participants will receive personalized coaching through online sessions and a fitness tracker. The goal is to see if this approach is feasible and acceptable, and whether…

This study tests whether a new therapy to improve coughing and swallowing works as well when done at home via telehealth as it does in person. About 120 people with Parkinson's disease who have trouble swallowing will take part. The goal is to find easier ways to help patients pr…

This study tests whether virtual reality dance games, like 'Just Dance', can help people who have had a stroke improve their balance and movement. Researchers will compare this fun, home-friendly approach to standard physical therapy. The goal is to see if it's safe, enjoyable, a…

This study follows 60 people with essential tremor or Parkinson's tremor whose symptoms aren't well-controlled by medication. After receiving stereotactic radiosurgery—a precise dose of radiation to a small brain area—participants fill out questionnaires about their quality of li…

This study tests a new nasal spray called XJN010 for people with Parkinson's disease who have 'off' episodes—times when their regular medication stops working and symptoms return. The trial will include 84 adults aged 30 to 85 and will measure how well the spray improves movement…

This observational study, led by the Michael J. Fox Foundation, aims to understand how Parkinson's disease progresses over time. It will follow 4,500 people, including those with Parkinson's, those at risk, and healthy volunteers, collecting clinical, imaging, and genetic data. T…

This study reviews the medical records of up to 5,000 people who have received deep brain stimulation (DBS) for Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in real-world settings. No new treatments are given…

This study aims to learn more about the brain activity behind risk-taking and reward-seeking behaviors in people with Parkinson's disease. Researchers will record brain signals during deep brain stimulation surgery while participants play a gambling task. The goal is to understan…

This study aims to learn more about the brain activity behind cognitive impairment in Parkinson's disease. Researchers will record brain signals from 75 people during deep brain stimulation surgery while they perform a gambling task. The goal is to understand how certain brain ar…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive radiofrequency (RF) ablation—a procedure that uses heat to target small areas in the brain. The goal is to see how p…

This study looks at how a specific gene change (LRRK2 mutation) affects brain chemicals in people with Parkinson's disease. Researchers will compare 15 participants with the mutation to others without it using brain scans, thinking tests, and movement tests. The goal is to better…

This study looks at how deep brain stimulation (DBS) changes motivation and decision-making in people with Parkinson's disease. Researchers will have 70 participants play a tablet game that measures risky vs. safe choices while their brain activity is recorded. The goal is to und…

This study uses a special PET scan tracer called [18F]DPA-714 to measure brain inflammation in people with early or suspected Parkinson's disease and in healthy volunteers. Researchers will scan participants at the start, after 12 months, and after 24 months to see how inflammati…

This study uses MRI scans to see how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Researchers will compare brain images when the stimulator is on versus off, focusing on the leg area of the brain. The goal is to understand why DBS someti…

This study looks for brain scan markers that might predict thinking and memory changes after Deep Brain Stimulation (DBS) in people with Parkinson's disease. Researchers will use MRI scans before surgery and cognitive tests after surgery in 55 Parkinson's patients, plus compare t…

This study looks at immune cells in the gut to understand how they might be linked to multiple sclerosis, Parkinson's disease, and REM sleep behavior disorder. Researchers will collect colon tissue samples from 100 adults during colonoscopy. The goal is to map these cells and the…

This study tests whether computer analysis of speech can reliably detect motor, emotional, and cognitive changes in people with Parkinson's disease. Researchers will record speech from 80 patients while they are on and off medication or deep brain stimulation. The goal is to find…

This study explores whether the gut's nervous system can reveal early signs of Parkinson's disease. Researchers will analyze gut tissue and microbiome samples from 60 people aged 45-75 during routine colonoscopies. The goal is to find biomarkers that reflect brain changes, not to…

This study is creating a large, open-access database of clinical, motor, and non-motor information from nearly 1,000 people with Parkinson's disease and healthy controls in Brazil. Researchers will collect data through questionnaires, movement tests, and clinical scales. The goal…

This study looks at how certain brain signals (called beta waves) affect movement in people with Parkinson's disease. Researchers will work with 25 patients already scheduled for deep brain stimulation (DBS) surgery. By using special stimulation and medication, they hope to learn…

This study aims to understand why some people with Parkinson's disease experience central pain. Researchers will use brain scans (PET and MRI) to examine the serotonin system in 34 participants. The goal is to see how serotonin relates to pain, not to test a new treatment.

This study uses a special PET scan tracer called DPA-714 to measure brain inflammation in people with Parkinson's disease compared to healthy volunteers. Researchers want to see if Parkinson's patients have higher levels of inflammation and how that relates to their symptoms. The…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study creates a registry to collect real-world information on the safety and effectiveness of ambroxol, a common cough medicine, when used at higher doses for Gaucher disease or GBA-related Parkinson disease. Researchers aim to gather data from 300 patients worldwide who are…

This study follows 150 people with early-stage Parkinson's disease to see if the condition starts in the brain or the body first. Researchers will track symptoms like walking problems and thinking changes over 5 years using tests, scans, and questionnaires. The goal is to better …

This study observes 280 people with Parkinson's disease or multiple system atrophy to understand how pain and automatic body functions (like blood pressure and digestion) affect their lives. Participants will undergo standard rehabilitation and be assessed with questionnaires. Th…

This study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…

This study aims to develop new ways to measure how much energy people with Parkinson's use during dance classes. Researchers will use cameras, wearable activity monitors, and questionnaires to track movement and intensity. The goal is to better understand the relationship between…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study is creating a national biobank of blood samples and health data from 230 people with Parkinson's disease or a related sleep disorder (REM sleep behavior disorder). Researchers will analyze the complete DNA of each participant to find rare genetic changes that may cause…

This study looks at how deep brain stimulation (DBS) affects the ability to stop actions in people with Parkinson's disease. Researchers will measure brain waves and behavior during impulse control tasks before, during, and after DBS surgery. The goal is to understand how stimula…

This study looks at how Parkinson's disease impacts breathing, muscle strength, and physical fitness. Researchers will compare 100 people aged 50-80 with Parkinson's to healthy volunteers. Participants will do breathing tests, fitness assessments, and disease severity evaluations…

This study aims to learn more about how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity during speech tasks while participants undergo deep brain stimulation (DBS) surgery. The study does not test…

This study looks at how thinking skills and brain activity relate to walking in people with Parkinson's disease and healthy older adults. Researchers will measure walking patterns, brain waves, and mental tests in 70 participants. The goal is to better understand why walking beco…

This study investigates why people with Parkinson's disease sometimes freeze while walking or turning. Researchers will use gentle electrical stimulation to the balance system and brain wave recordings to understand the signals involved. The goal is to find biological markers tha…

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study watches brain activity in 25 Parkinson's patients during their planned DBS surgery. Researchers place a thin sensor strip on the brain's surface to record signals while stimulating deep brain areas. The goal is to understand how movement-related brain pathways work, wh…

This study uses a special PET scan with a radioactive tracer called [18F]F-DOPA to measure dopamine production in the brains of people with autonomic failure (problems with automatic body functions like blood pressure). The goal is to see if changes in dopamine levels can predict…

This study records brain activity from people with movement disorders like Parkinson's disease, essential tremor, and dystonia. Researchers use scalp electrodes or existing deep brain stimulators to measure electrical signals. The goal is to find patterns linked to symptoms, whic…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep disorder called REM sleep behavior disorder (iRBD). Researchers will compare sleep quality among these groups and healthy volunteers using overnight sleep tests. The goal is to better und…

This study looks at how deep brain stimulation (DBS) affects walking and other movements that don't improve with standard Parkinson's medication. About 36 adults with Parkinson's who already have a Medtronic Percept DBS implant will wear sensors and use a smartphone app to track …

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study looks at why some people with Parkinson's disease suddenly feel like their feet are glued to the floor, known as freezing of gait. Researchers will use special brain recordings from already-implanted devices to compare brain activity in people with and without this sym…

BLAAC PD is a research study that aims to understand what Parkinson's disease looks like for Black and African American communities. Researchers will collect genetic and health information from 2,000 participants across the U.S. to explore risk factors and genetic causes of Parki…

This study is testing whether wearable sensors can accurately measure how people climb stairs. Researchers will compare sensor data to traditional stopwatch timing in healthy volunteers and people with conditions like cerebral palsy, Parkinson's disease, and stroke. The goal is t…

This study looks at how different types of treadmill training affect the gut bacteria and symptoms of people with Parkinson's disease. Sixty participants will be split into three groups: one doing standard physiotherapy, one using a C-Mill treadmill, and one using the C-Mill with…

This study looks at how balance problems, walking difficulties, physical activity, and sleep quality are related in people with Parkinson's disease. Researchers will compare 34 Parkinson's patients to healthy adults of similar age to see which issues are due to Parkinson's and wh…

This study uses small motion sensors to detect internal tremors—a common but hard-to-measure symptom—in people with Parkinson's disease. Researchers will compare 60 participants (30 with Parkinson's and 30 healthy volunteers) to see if a specific 4-6 Hz rhythm can be identified. …

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will test the translated version with 190 Italian-speaking patients to make sure it works correctly. The goal is to give doctors a reliab…

This study looks at how Parkinson's disease changes social behavior and quality of life. Researchers will compare 500 adults with Parkinson's to healthy adults of the same age. Participants will answer questions about their daily activities, mood, memory, and social interactions.…

This study is testing whether artificial intelligence (AI) can analyze brain scans to help diagnose Parkinson's disease and related conditions like multiple system atrophy. Researchers will also see if the scans can predict how fast the disease will progress. The study involves 9…

This study looks at how deep brain stimulation (DBS) affects brain activity in 30 people with Parkinson's disease. Researchers will measure brain signals during movement and thinking tasks, with and without DBS or medication. The goal is to understand how different brain areas wo…

This study collects information and samples from 1,000 people with or at risk for brain diseases like Alzheimer's, ALS, and frontotemporal degeneration. Researchers will track changes in thinking, language, and brain scans over time. The goal is to build a resource for future stu…

This study is looking for simple ways to detect early signs of multiple sclerosis and Parkinson's disease in people who drive. Researchers will test 200 drivers with these conditions using computer-based attention and reaction tests. The goal is to find quick, easy tests that cou…

This study looks at how the brain handles sensory information in people with Parkinson's disease. Researchers will measure brain activity and arm movements in 30 participants during deep brain stimulation surgery. The goal is to understand the brain's role in movement problems, w…

This observational study looks at how gut bacteria relate to brain structure and function in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will use brain scans, stool samples, blood tests, and cognitive assessments in 200 part…

This study is testing whether a new, low-cost type of brain scan can find early signs of Alzheimer's and Parkinson's disease. Researchers will compare brain scans from 120 people, including those at risk for Alzheimer's, those with Parkinson's, and healthy volunteers. The goal is…

This study is testing whether new brain imaging techniques can better diagnose diseases like Parkinson's, multiple system atrophy, and frontotemporal dementia. Researchers will use MRI scans and neurological exams in about 94 adults aged 40-85. The goal is to improve how doctors …

This observational study looks at whether long-term use of immunosuppressive drugs (taken for other conditions) can slow the onset or progression of Parkinson's disease. Researchers will compare 80 people with Parkinson's—half on immunosuppressants, half not—by tracking motor sym…

This study uses a non-invasive brain stimulation technique called TMS to measure brain activity in 52 people with Parkinson's disease. The goal is to see if these measurements can tell the difference between normal thinking, mild cognitive impairment, and dementia, and predict fu…

This study looks at how Parkinson's disease affects the brain's ability to control actions, like stopping or switching tasks. Researchers will have 50 people with Parkinson's do joystick tasks while on their usual dopamine medication. The goal is to better understand these brain …

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …

This study records brain activity during deep brain stimulation (DBS) surgery in 140 people with Parkinson's disease or essential tremor. Researchers aim to understand brain networks linked to non-motor symptoms like depression, attention problems, and slow thinking. Participants…

This study looks at how deep brain stimulation (DBS) for Parkinson's disease affects speech. Researchers will record voices of 60 participants before and after surgery to measure changes in clarity, emotion, and word choice. The goal is to better understand the benefits and risks…

This study aims to find new biological markers for neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze genetic, protein, and metabolic data from 1,200 patients to improve diagnosis, predict disease course, and monitor treatment response. Th…

This study is looking for 500 people with early dementia or mild cognitive impairment to help develop a way to predict how their disease will progress. Researchers will use blood tests and other models to better understand each person's outlook. The goal is to give patients and d…

This study looks at whether allowing people with Parkinson's disease to make choices during practice helps them learn new motor skills. Researchers will compare two groups: one that can choose when to receive feedback and one that cannot. The goal is to see if autonomy improves l…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

This study is looking at how deep brain stimulation (DBS) affects brain activity in people with Parkinson's disease. Researchers will record brain signals during DBS surgery to better understand which areas to stimulate and how to set the device for each person. The goal is to ma…

This study looks at how midodrine and droxidopa, two drugs used for low blood pressure upon standing, affect the veins in the abdomen of people with autonomic failure. About 34 adults aged 40-80 with conditions like multiple system atrophy or Parkinson's disease will participate.…

This study looks at why deep brain stimulation (DBS) for Parkinson's disease can sometimes cause thinking problems. Researchers will scan the brains of 55 people with DBS implants while their device is on or off. The goal is to understand how stimulation affects brain networks, w…

This study uses advanced brain scans (PET, SPECT, and MRI) to find markers of Parkinson's disease in people with certain genetic mutations. Researchers will look at changes in brain chemicals and structure. The goal is to better understand the disease and help develop new treatme…

This study aims to understand how inflammation in the brain works in Parkinson's disease. Researchers will give a mild inflammatory compound (LPS) to 30 volunteers—some with Parkinson's, some with a sleep disorder linked to Parkinson's, and some healthy—and use special PET-MR bra…

This study uses special brain scans (PET, SPECT, and MRI) to look for a marker that shows how Parkinson's disease changes over time. Researchers will scan 44 people with Parkinson's to see if a compound called BU99008 can highlight brain cell activity linked to the disease. The g…

This study is building a large database of health information from 250 people with Parkinson's disease and related conditions. Researchers will collect data on symptoms, treatments, genetics, and brain scans over time. The goal is to better understand how the disease progresses a…

This study uses advanced brain scans (PET and MRI) to examine serotonin activity in people with Parkinson's disease. Researchers will compare brain images from 42 participants at different stages of the disease. The goal is to find biological markers that could lead to new treatm…

This study is observing 100 people with Parkinson's disease who are receiving complementary therapies like homeopathy, herbalism, hypnosis, and healing at a special clinic. Participants also get advice on lifestyle, mindfulness, and diet. The goal is to document their experiences…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…

This observational study at the Medical University of Graz will examine 216 people with movement disorders like Parkinson's, tremor, or dystonia to see how many also have functional neurological symptoms. Participants will undergo neurological exams, cognitive tests, and question…

This study looks at why many people with Parkinson's disease eat more sugary foods. Researchers will give 50 participants a sugary drink or a placebo on different days, then measure blood sugar, insulin, and movement symptoms. The goal is to see if fast-acting sugars temporarily …

This study is screening 2,000 people aged 50 to 99 who may have a higher risk of developing Parkinson's disease. Researchers will follow participants for five years to track early changes in risk markers and symptoms. The goal is to better understand how Parkinson's develops and …

This study uses a tiny, high-density brain probe to record activity from thousands of neurons during awake brain surgery in 15 Parkinson's patients. The goal is to understand how different layers of the brain's cortex handle tasks like planning and decision-making. It does not te…