PARKINSON DISEASE

This study tests whether swallowing and cough training for people with Parkinson's disease works as well when delivered through video calls (telehealth) as it does in person. Researchers will enroll 120 participants to compare both methods over a year, including an intensive 4-we…

This study is testing an investigational drug called BIIB122 in people with Parkinson's disease caused by specific genetic changes in the LRRK2 gene. About 50 participants will receive either the drug or a placebo for 12 weeks to see if it's safe and how it affects certain biolog…

This study is testing whether playing gentle sounds during sleep to enhance deep sleep can slow the progression of brain changes in people with isolated REM sleep behavior disorder (iRBD) or early Parkinson's disease. Participants will wear a special headband and headphones at ni…

This study aims to observe how well the medication opicapone works and how safe it is for people with Parkinson's disease who are experiencing early motor fluctuations. It will follow 200 patients in Italy for up to two years as they take opicapone alongside their standard levodo…

This is an early safety study for a new cell therapy called NouvNeu001 for people with advanced Parkinson's disease. Doctors will surgically transplant the cells into a specific part of the brain. Participants will need to take anti-rejection medication for about 6 to 9 months to…

This study aims to learn how Parkinson's disease patients in real life use a medication called SL-APO to manage their 'off' episodes, when symptoms return. Researchers will observe 90 patients as they and their doctors work to find the most effective and tolerable dose. The goal …

This study is testing whether silymarin, a natural antioxidant found in milk thistle, can protect brain cells and help manage symptoms in people with Parkinson's disease. It will involve 50 participants aged 45-65 who are already on standard Parkinson's medication. Researchers wi…

This study is testing whether a medication called varenicline, taken for one year, can help reduce the risk of falls and improve the ability to walk while doing another task (like talking) in people with Parkinson's disease who also have mild memory problems. About 102 participan…

This is a very early study testing the safety of a new one-time gene therapy called IPS101A for people with advanced Parkinson's disease. It will involve 6 participants whose symptoms are severe and not controlled by all available medications. The main goal is to find a safe dose…

This study is testing if a dietary supplement called tributyrin can help improve memory, thinking, walking, and balance in adults with Parkinson's disease who also have mild memory problems or dementia. Researchers will compare the supplement to a placebo pill over about 90 days …

This study is collecting real-world information on how a specific brain ablation procedure affects patients' quality of life. It will follow 200 people with Parkinson's disease, dystonia, or essential tremor who are scheduled to receive the treatment. The goal is to understand th…

This early-stage trial is testing whether a personalized stem cell transplant is safe for people with Parkinson's disease. Doctors will take skin cells from each participant, reprogram them into brain cells, and transplant them into the brain. The study will follow 8 participants…

This study is testing a non-surgical radiation treatment for people with severe hand tremor from Essential Tremor or Parkinson's disease. It aims to see if this one-time, outpatient procedure improves patients' quality of life and reduces shaking. Participants will complete quest…

This study is testing whether a gene therapy delivered directly into the brain can help control symptoms in people with moderate Parkinson's disease. Participants will receive either the real gene therapy or a sham (fake) surgery, and neither they nor the doctors will know which …

This study is observing how 120 people with Parkinson's disease use a continuous medication pump (ONAPGO™) in their daily lives. The pump delivers a drug called apomorphine under the skin to help control movement symptoms. Researchers will track how long it takes to find the righ…

This study is testing whether a new type of brain stimulation can improve movement problems in people with Parkinson's disease. A small group of participants will first try a non-invasive brain stimulation test. If they respond well, they will have electrodes surgically placed on…

This study is testing whether a surgical brain stimulation treatment, when added to the best available medication, can better control serious behavioral problems in people with Parkinson's disease. Sixty participants with Parkinson's and these specific impulse control disorders w…

This study is testing whether celecoxib, an anti-inflammatory medication, can help slow Parkinson's disease progression by reducing brain inflammation. Researchers will enroll 80 adults with Parkinson's to measure changes in their symptoms over time. The trial aims to see if targ…

This study is testing whether a 12-month, home-based aerobic exercise program can improve thinking skills and slow cognitive decline in people with Parkinson's disease who have mild memory problems. Researchers will enroll 150 participants to compare those who follow the exercise…

This study is testing whether metformin, a common diabetes medication, can help control Parkinson's disease symptoms. Researchers will enroll 60 patients aged 50+ who are already taking standard Parkinson's medication. They'll measure changes in movement symptoms and quality of l…

This study is testing whether following a Mediterranean diet for three months can help control weight gain and improve body composition in Parkinson's disease patients who have undergone deep brain stimulation surgery. Researchers will compare a group receiving Mediterranean diet…

This study is testing whether a non-invasive ultrasound procedure can help control movement symptoms in people with early-stage Parkinson's disease. Researchers will compare the focused ultrasound treatment, which targets a specific brain area, against standard medication managem…

This study is testing whether montelukast, a medication commonly used for asthma and allergies, can help control Parkinson's disease symptoms. The trial will involve 60 people with Parkinson's who are already taking levodopa medication. Researchers will measure changes in movemen…

This study is testing whether a drug called vinpocetine is safe and can help control the symptoms of Parkinson's disease. It will involve 60 people who are already taking standard Parkinson's medication. Researchers will measure changes in symptoms and look at specific markers in…

This study is testing a new wearable sensor that provides feedback during swallowing exercises. It aims to see if this device helps people with swallowing difficulties after a stroke or from Parkinson's disease improve more than standard therapy alone. The research will also comp…

This is an early-stage study to check the safety and how the body processes a new drug called LY4006896. It will involve about 127 healthy volunteers and people with Parkinson's disease. The main goal is to see how well the drug is tolerated and to measure its levels in the body …

This study follows 270 Italian adults with advanced Parkinson's disease who are already prescribed the medication Foslevodopa/Foscarbidopa. Researchers will observe how the treatment affects patients' quality of life and daily activities over 12 months in a real-world setting, no…

This study is testing whether following a Mediterranean-style diet for 18 months can help manage Parkinson's disease symptoms by influencing gut health. Researchers will compare this special diet to standard eating habits in 40 people with Parkinson's, tracking symptoms, gut bact…

This study is testing a new type of directional brain electrode (CARTESIA™) for people with Parkinson's disease who are already scheduled for deep brain stimulation (DBS) surgery. The goal is to see if this newer electrode can better control movement symptoms like tremors and sti…

This study is testing whether a safe, non-invasive electrical stimulation applied to the head and spine can make walking and balance training more effective for people with Parkinson's disease. 71 participants, including 51 with Parkinson's and 20 healthy volunteers, will undergo…

This study is testing an oral medication called NEU-411 for people with early Parkinson's disease who have a specific genetic profile linked to the disease. About 150 participants will take either the drug or a placebo for one year to see if it can slow the progression of Parkins…

This study is exploring whether a non-invasive brain stimulation technique can improve thinking problems and mood in people with several brain-based conditions. Researchers will use a magnetic coil placed on the head to stimulate a part of the brain called the cerebellum in 200 p…

This study is testing whether a 6-month, home-based exercise program can help slow down thinking and memory problems in people with Parkinson's disease. Researchers will enroll 32 participants to compare a supervised workout plan with a no-exercise group. They will measure change…

This study is testing an oral medication called CVN424 to see if it can help people with Parkinson's disease who experience 'OFF' periods, when their standard medications wear off and symptoms return. About 330 participants will take either one of two doses of the drug or a place…

This study is a small, early-stage trial to see if it's possible to run a larger future study. It aims to find out if changing the mix of two ingredients (Carbidopa and Levodopa) in a common Parkinson's disease medication can better control sudden drops in blood pressure when sta…

This program provides early access to the investigational drug tavapadon for people with Parkinson's disease before it is officially approved. It is for eligible patients whose doctors determine the potential benefits outweigh the risks. The program is not for people who have oth…

This study is testing whether an 'adaptive' deep brain stimulation system works better than the standard continuous system for people with Parkinson's disease. Researchers want to see if the adaptive system gives patients more daily hours of good movement control with fewer troub…

This study follows Parkinson's patients who have been receiving an experimental brain treatment for several years. Researchers want to safely help patients stop this treatment by gradually reducing their dose and switching to alternative medications. The main goal is to monitor s…

This study is testing whether an investigational drug called BHV-8000 can slow the progression of Parkinson's disease in people recently diagnosed. Researchers will compare the drug to a placebo in 550 adults to see if it helps maintain daily function and movement abilities over …

This study is testing whether a community cycling exercise program can slow the progression of Parkinson's disease. Researchers will enroll 200 people with Parkinson's to attend cycling classes three times a week for a year. They will also check participants' genetic profiles to …

This trial is testing whether a new drug called dapansutrile can slow the progression of Parkinson's disease by reducing inflammation in the brain and body. Researchers will enroll 36 people with early-stage Parkinson's to take either the drug or a placebo pill daily for six mont…

This study is testing whether fexofenadine, a common allergy medication, can improve quality of life for people with Parkinson's disease who are already taking standard treatments. Researchers will add fexofenadine to existing medications to see if it helps with movement problems…

This study aims to collect long-term safety and effectiveness data on Abbott's deep brain stimulation (DBS) systems. It will follow 1,000 patients with Parkinson's disease, essential tremor, or dystonia for five years after their device is implanted and programmed. The goal is to…

This study is testing whether doctors can detect Parkinson's disease earlier by looking for a specific protein in colon tissue samples taken during routine colonoscopies. Researchers are enrolling 20 adults with Parkinson's who are already scheduled for colon cancer screening. Th…

This study is testing if a smartphone app can help detect and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by analyzing changes in a person's speech. Researchers will compare speech recordings from 150 people with these condition…

This study is testing new digital tools to improve how Parkinson's disease is diagnosed and monitored. Researchers will use special sensors to measure eye movements and walking patterns in 100 people with Parkinson's. They will use this data to train computer programs (AI) to hel…

This study is testing whether doctors can detect early signs of Parkinson's disease or REM sleep behavior disorder by analyzing tiny tissue samples taken during routine colonoscopies. Researchers are looking for a specific protein that builds up in people with these conditions. T…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The goal is to see if this tool can make diagnosis faster and more accurate, as current methods often lead to misdiagnosi…

This study is testing an improved version of a special PET scan called 18F-DOPA. The goal is to see if using a newer scanner and a common medication (furosemide) can make the images clearer, especially in the lower abdomen. This could help doctors better detect and plan treatment…

This study aims to develop better tools for diagnosing Parkinson's disease and similar movement disorders. Researchers will use advanced brain scans and artificial intelligence to identify patterns that can distinguish between different conditions and predict how quickly they mig…

This study is testing three new types of brain scans to see if they can better detect and track Parkinson's disease and related conditions. It will involve 500 adult patients who either have or are suspected of having Parkinson's. The goal is to see if these scans can more accura…

This study aims to find simple clinical tests that can help detect early signs of multiple sclerosis (MS) and Parkinson's disease in drivers. Researchers will compare results from standard driving-related computer tests with basic neurological and cognitive exams in 200 participa…

This study is testing if becoming more physically active can help preserve memory and thinking skills in people with a specific sleep disorder that puts them at very high risk for developing Parkinson's disease or a related dementia. Researchers will use a motivational smartphone…

This study is testing whether an experimental nasal spray called XJN010 can help people with Parkinson's disease quickly recover from 'off' episodes—periods when their medication wears off and movement becomes difficult. Researchers will compare the spray to a placebo in 84 patie…

This study is testing if adding 'motor imagery'—mentally practicing movements—to standard physical therapy can help people with Parkinson's disease. Researchers want to see if this combination improves balance and reduces the fear of movement that can lead to falls. Participants …

This study is testing a smart wearable device called gaitQ, which is worn on the legs. It uses gentle vibrations to help people with long-term movement conditions like Parkinson's, stroke, and multiple sclerosis improve their walking, reduce freezing episodes, and potentially low…

This study compares two common treatments for low blood pressure when standing up in people with autonomic nervous system disorders. Researchers will test whether a medication called midodrine or wearing an abdominal compression binder works better to improve blood flow and reduc…

This study is testing if a specific type of fast-paced, bodyweight exercise done at home can help reduce movement slowness (bradykinesia) in people with Parkinson's disease. Researchers will remotely guide 46 participants through a 12-week program, comparing fast exercises to reg…

This study is testing whether specific walking training using metronomes can improve how people with Parkinson's disease walk. Participants will complete 12 training sessions using slow and fast metronome beats on a treadmill and overground walking. Researchers will measure walki…

This study aims to find out which type of exercise—cardio, strength training, or a mix of both—best improves sleep quality for people with Parkinson's disease. Researchers will enroll 150 participants with mild-to-moderate Parkinson's and poor sleep, assigning them to one of thre…

This study is testing if adding supervised pool exercises (aquatherapy) to a home exercise program helps people with Parkinson's disease more than home exercises alone. It will measure changes in walking, balance, posture, pain, depression, and ability to do daily tasks. The goal…

This study is testing whether gentle electrical stimulation of the ear (targeting the vagus nerve) can improve apathy—a common loss of motivation—in people with Parkinson's disease. For two weeks, 60 participants will receive either the real stimulation or a sham (fake) treatment…

This study is testing two different exercise schedules for Veterans with moderate Parkinson's disease. It compares a high-volume schedule (intense weeks followed by rest) to a steady, moderate weekly schedule. The goal is to see which approach better improves walking speed, daily…

This study is testing a speech therapy and counseling program designed specifically for Korean-speaking immigrants in the US who have Parkinson's disease. It aims to improve speech clarity and ease of communication for patients, while also supporting their family caregivers. The …

This study is testing whether a mobile app called SpiroGym, which provides visual feedback, helps people with Parkinson's disease perform breathing exercises more effectively. Thirty participants will complete two training sessions, one with the app's feedback and one without, to…

This study is testing whether a daily probiotic supplement can help reduce depression in people who have Parkinson's disease. About 60 participants with mild to moderate Parkinson's and depression will take either the probiotic or a placebo pill for 12 weeks. Researchers will mea…

This study is testing whether a non-invasive brain stimulation technique can help improve apathy (loss of motivation) in people with Parkinson's disease. Fifteen participants will receive multiple short magnetic stimulation sessions each day over two weeks. Researchers will measu…

This study is testing whether a temporary, minimally invasive spinal cord stimulator can help people with advanced Parkinson's disease walk more steadily. The device, placed near the spine, sends electrical pulses and is being tried to reduce episodes where patients suddenly feel…

This study is testing whether a non-invasive brain stimulation technique, called repetitive transcranial magnetic stimulation (rTMS), can help improve balance and stability in people with Parkinson's disease. About 40 patients will be randomly assigned to receive either physical …

This study aims to see if an online self-management program works as well as traditional in-person training for people with early-stage Parkinson's disease. Researchers will compare both approaches to a group receiving no extra therapy, focusing on how they affect participants' a…

This study is testing whether adding special laser-guided exercises to standard physical therapy helps people with Parkinson's disease improve their balance and ability to do daily activities. Researchers will compare two groups: one doing standard exercises and another doing sta…

This study is testing a non-invasive brain stimulation technique to see if it can reduce movement slowness (bradykinesia) in people with Parkinson's disease. Researchers will use a device that creates a magnetic field to stimulate a specific area of the brain right before a perso…

This study is testing whether a medication called pyridostigmine can safely and effectively treat chronic constipation in people with Parkinson's disease. Sixteen participants with Parkinson's and significant constipation will take the medication for several weeks while tracking …

This study is testing whether a specific set of rotation exercises can help people with early-stage Parkinson's disease reduce their risk of falling and improve their mobility and balance. Researchers will compare a group doing these extra exercises to a group receiving standard …

This study is testing a phone app designed to help reduce anxiety in people with Huntington's or Parkinson's disease. The app uses daily exercises to help participants change unhelpful, negative thought patterns. Researchers will compare the app's effects on anxiety and quality o…

This study is testing whether a wearable leg device called Cue2Walk can improve daily life for people with Parkinson's disease who experience 'freezing of gait'—sudden, temporary episodes where they feel stuck while walking. The device automatically detects these freezing moments…

This study is testing a new digital tool designed to help people with Parkinson's disease monitor and manage their non-motor symptoms, such as pain, sleep problems, and mood changes. Thirty participants and their care partners will use the smartphone-based system for six months t…

This study is testing whether adjusting the settings on a deep brain stimulation implant can help improve sleep for people with Parkinson's disease who have severe insomnia. Researchers will enroll 10 participants who already have the implant and see if stimulating a different br…

This study is testing whether a non-invasive ultrasound treatment can improve symptoms for people with Alzheimer's, Parkinson's, or related brain diseases. Researchers will use focused sound waves to stimulate the brain, aiming to improve movement, memory, and daily life quality.…

This study is testing whether a non-invasive electrical stimulation device placed on the back can improve walking and balance in people with Parkinson's disease. Researchers will apply gentle stimulation to multiple points along the spine while participants perform walking and ba…

This study is testing a new online program designed to help people with Parkinson's disease in Qatar become more physically active. Researchers are adapting a proven coaching method for remote, culturally appropriate delivery. The pilot trial with 40 participants will check if th…

This study is testing whether people with Parkinson's disease can safely use a special brain stimulation device at home. Participants will learn to use the device, then try it daily for a week while being monitored remotely. Researchers want to see if it's practical and safe, and…

This study is testing a new, 'adaptive' version of deep brain stimulation (DBS) to see if it can safely help with walking and balance problems in people with Parkinson's disease. It involves 10 participants who already have a specific Medtronic Percept DBS implant. The device wil…

This study is testing whether a special 8-week exercise program done in a pool can help people with Parkinson's disease. Researchers want to see if high-intensity water workouts improve balance, physical function, and muscle strength compared to standard care. The program involve…

This study is testing if a CPAP machine, commonly used for sleep apnea, can help people with autonomic failure. These patients often have dangerously high blood pressure when lying down and severe dizziness when standing up. Researchers want to see if using CPAP at night can safe…

This study is testing if a gentle, non-invasive brain stimulation technique can improve movement problems like walking, speech, and eye control. It involves people with Parkinson's disease and two related neurological conditions. Participants will do walking sessions while receiv…

This study is testing whether a device that sends mild electrical pulses to the spinal cord is safe for Parkinson's patients who have a painful, forward-bending posture called camptocormia. The goal is to see if this stimulation can help reduce pain and improve posture when other…

This study aims to understand how Parkinson's disease disrupts the brain's ability to control actions like stopping or switching movements. Researchers will compare 50 Parkinson's patients taking their regular dopamine medication to healthy volunteers using simple joystick comput…

This study aims to understand how walking difficulties, balance problems, daily activity levels, and sleep quality are connected in people with Parkinson's disease. Researchers will compare 17 people with Parkinson's to 17 healthy adults of similar age, using walking tests, balan…

This study aims to understand how different settings on a deep brain stimulation (DBS) device affect sleep quality and brain activity in people with Parkinson's disease. Researchers will study 10 participants who already have a specific DBS system implanted. The goal is to gather…

This study aims to understand how alcohol affects shaking in people with different tremor conditions like essential tremor, dystonia, and Parkinson's disease. Participants will drink either an alcoholic beverage or a non-alcoholic placebo on separate days while researchers measur…

This study aims to find a measurable sign, or biomarker, of Parkinson's disease progression. Researchers will use specialized brain scans (PET, SPECT, and MRI) on 44 participants to look at chemical and structural changes over a one-year period. The goal is to better understand t…

This study aims to understand how different settings on existing deep brain stimulation devices affect walking, balance, and movement in people with Parkinson's disease. Researchers will use brain scans to create personalized computer models for 60 participants who already have t…

This study aims to understand the experiences of Parkinson's disease patients who visit a specialized complementary medicine clinic. Researchers will observe 100 patients receiving therapies like homeopathy, herbalism, and hypnosis alongside their regular medical treatment. The g…

This study aims to understand why some Parkinson's patients experience thinking and memory problems after deep brain stimulation (DBS) surgery. Researchers will use MRI brain scans on 55 patients who have had the surgery, comparing brain activity with the stimulation turned on an…

This study aims to understand how the brain processes sensory information in people with Parkinson's disease. Researchers will record brain activity from 30 participants (both healthy individuals and Parkinson's patients) during deep brain stimulation surgery while they perform s…

This study aims to understand if a safe, non-invasive brain scan technique can spot early signs of memory and thinking problems in people with Parkinson's disease. Researchers will measure brain activity in 52 participants with Parkinson's, some with and some without cognitive is…

This research study aims to understand how Parkinson's disease affects Black and African American communities, who have been underrepresented in past research. It will enroll 2,000 people across the U.S., including those with Parkinson's and healthy volunteers over 50. Participan…

This study is exploring whether a special treadmill-based rehabilitation program can change the gut bacteria and improve symptoms in people with Parkinson's disease. Researchers will compare standard physical therapy to the treadmill, both with and without virtual reality games. …

This study uses a special brain scan to measure dopamine activity in people with autonomic failure conditions like Parkinson's disease, multiple system atrophy, and Lewy body dementia. Researchers want to see if these scans can detect early changes that might predict which patien…

This study aims to understand the role of brain inflammation in Parkinson's disease. Researchers will compare 30 people with Parkinson's to healthy volunteers. They will use special brain scans before and after giving a compound that causes a mild, temporary inflammatory response…

This study aims to understand how well deep brain stimulation (DBS) works in everyday practice for people with Parkinson's disease, essential tremor, or dystonia. Researchers will look back at the medical records of up to 5,000 people who have already had or are eligible for the …

This study aims to better understand how much exercise people with Parkinson's get during special dance classes. Researchers will use cameras and wearable sensors to record 60 participants during their regular 'Dance for PD' sessions. The goal is to measure the intensity of the d…

This study aims to understand how listening to personally chosen music might help reduce apathy—a common lack of motivation and emotion—in people with Parkinson's disease. Researchers will enroll 50 participants to use an 8-week music listening program while measuring changes in …

This study aims to understand how two existing medications, midodrine and droxidopa, affect blood flow in the abdomen of people with autonomic failure, a rare nerve disorder that causes severe drops in blood pressure when standing. Researchers will compare the drugs' effects on 3…

This study aims to understand the connection between brain activity, thinking skills, and walking ability in people with Parkinson's disease. Researchers will measure brain waves and walking patterns in 70 participants, including healthy older adults and those with Parkinson's. T…

This study aims to understand how a new wrist-worn device that provides gentle, rhythmic taps (called tactile cueing) affects walking and brain activity in people with Parkinson's disease. Researchers will enroll 60 participants to test if these personalized cues can make walking…

This study aims to understand how deep brain stimulation (DBS) affects walking, balance, and other movement problems in people with Parkinson's disease. Researchers will use a special, already-implanted DBS device to record brain signals while 36 participants perform daily activi…

This study aims to understand how different brain areas communicate in Parkinson's disease to improve deep brain stimulation (DBS) treatment. Researchers will record brain activity from 25 Parkinson's patients during their scheduled DBS surgery using an additional thin sensor str…

This study aims to understand how deep brain stimulation (DBS) works to improve movement and speech in people with conditions like Parkinson's disease or essential tremor. Researchers will test 60 patients who are already scheduled for DBS surgery, adding extra measurements durin…

This study aims to understand how the bacteria in our gut might be connected to changes in the brain during normal aging and in diseases like Alzheimer's, Parkinson's, and Multiple Sclerosis. Researchers will compare 200 participants, including healthy people of different ages an…

This study aims to understand how Parkinson's disease affects a person's social interactions, daily independence, and overall quality of life. Researchers will compare 500 adults with Parkinson's to adults of the same age without the condition. The goal is to gather knowledge to …

This study aims to create an Italian version of a questionnaire that measures stomach and bowel problems in Parkinson's disease patients. Researchers will translate and test the questionnaire with 190 Italian-speaking Parkinson's patients across multiple centers. The goal is to g…

This study aims to understand how Parkinson's disease progresses differently in people depending on whether it starts in the brain or the body. Researchers will follow 150 patients for five years, tracking their walking, balance, thinking skills, and biological markers. The goal …

This study aims to better understand Parkinson's disease by looking at brain chemistry and structure. Researchers will use advanced brain imaging scans (PET, SPECT, and MRI) on 42 participants aged 25-85 to identify biological markers of the disease. The findings could help guide…

This study aims to understand the brain activity behind reward-seeking and risk-taking behaviors in people with Parkinson's disease. Researchers will record brain signals from 75 participants during their scheduled deep brain stimulation surgery while they play a simple card game…

This study aims to find a measurable sign, or biomarker, of Parkinson's disease using advanced brain scans. Researchers will scan 45 people who carry genetic mutations linked to Parkinson's to better understand brain changes. The goal is to gather knowledge that helps develop fut…

This study aims to understand how the brain controls thinking skills by recording brain cell activity during awake Parkinson's surgery. Researchers will insert a special probe into the brain of 15 patients who are already undergoing deep brain stimulation surgery. The goal is to …

This study aims to better understand diseases like Alzheimer's and Parkinson's by analyzing the genes, proteins, and other molecules in people who have them. Researchers will collect blood and other samples from 1200 participants to look for patterns that could lead to new ways t…

This study aims to learn if long-term immunosuppressive drug treatment for other chronic illnesses can slow down the progression of Parkinson's disease. Researchers will compare 80 people with Parkinson's—some taking these immune-suppressing drugs and some not—by measuring their …

This study aims to find biological markers that can track how Parkinson's disease progresses over time. It will follow 4,500 people, including those recently diagnosed, those at high risk, and healthy volunteers, collecting detailed health data and samples. The goal is to build a…

This study aims to find early warning signs of Parkinson's disease in people who don't yet have symptoms. Researchers will screen 2,000 adults aged 50-99 who are at higher risk and follow them for five years to see who develops the disease. The goal is to understand how Parkinson…

This study aims to understand how often functional neurological disorders (FND) occur in people who already have movement disorders like Parkinson's or tremor. Researchers will examine 216 patients to identify the frequency and characteristics of these overlapping symptoms. The g…

This study uses special brain scans to measure inflammation in people with early or pre-symptomatic Parkinson's disease. Researchers will follow 60 participants for two years to see how brain inflammation changes over time. The goal is to better understand Parkinson's progression…

This study aims to understand how deep brain stimulation surgery affects speech in people with Parkinson's disease. Researchers will record the voices of 60 patients before surgery and at 6 and 12 months after. By analyzing changes in voice quality, rhythm, and word choice, they …

This study aims to better understand sleep problems in people with Parkinson's disease and those with a related sleep disorder called REM sleep behavior disorder. Researchers will compare sleep patterns in 457 participants across three groups: people with Parkinson's, people with…

This study aims to find a way to objectively measure 'internal tremors'—a shaking sensation some Parkinson's patients feel inside that isn't visible. Researchers will use motion sensors on 60 people (both Parkinson's patients and healthy volunteers) to see if they can detect a sp…

This study is investigating whether giving people with Parkinson's disease more control over their practice can help them learn new movements better. Researchers will have participants learn a finger-tapping task on a computer, with one group choosing when they get feedback and a…

This study aims to understand how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity from 80 participants while they perform speech tasks during deep brain stimulation surgery. The goal is to learn h…

This study aims to understand how the brain changes and adapts in various neurological conditions and during normal aging. Researchers will use advanced, high-powered MRI scans to look at brain structure, function, and energy use in 700 participants, including people with disease…

This study aims to better understand how different parts of the brain work together in people with Parkinson's disease. Researchers will study brain activity in 30 participants who are already scheduled to receive a deep brain stimulation (DBS) implant as part of their regular ca…

This study aims to understand how brain activity relates to thinking and memory problems in Parkinson's disease. Researchers will measure brain signals from 75 Parkinson's patients during their deep brain stimulation surgery while they perform simple thinking tasks. The goal is t…

This study aims to create a better prediction model for how memory and thinking problems worsen over time in people with early dementia or mild cognitive impairment. Researchers will collect blood samples, perform brain scans, conduct memory tests, and gather information from clo…

This study aims to understand how brain activity is linked to non-motor symptoms in Parkinson's disease, like depression and thinking problems. Researchers will record brain activity from 140 participants during their routine deep brain stimulation surgery while they perform simp…

This study aims to better understand how Deep Brain Stimulation (DBS) affects brain activity in people with Parkinson's disease. Researchers will record brain signals during surgery to create detailed maps that might help doctors place electrodes more precisely and program the de…

This study is creating a detailed database of information from 250 people with Parkinson's disease and related conditions. Researchers will collect health data, biological samples, and brain images over many years to better understand how the disease progresses and what factors i…

This study is trying to understand why many people with Parkinson's disease crave sugary foods. Researchers will give 50 participants a sugary drink or a placebo drink on different days to see how it affects their blood sugar, insulin levels, and Parkinson's symptoms like movemen…

This study aims to find new, low-cost ways to detect Alzheimer's and Parkinson's disease earlier. Researchers will use MRI brain scans and a memory task to look for specific patterns in brain connections in 120 people, including patients and healthy volunteers. The goal is to ide…

This study aims to understand how Parkinson's disease affects breathing strength, lung function, and physical fitness. Researchers will compare 100 people with Parkinson's to a group of healthy adults of similar age. The goal is to gather detailed information to help guide future…

This study aims to understand why some people with Parkinson's disease experience 'freezing of gait,' a sudden and temporary inability to start walking or continue moving. Researchers will measure brain activity in 36 participants who already have a specific deep brain stimulatio…

A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.