PARKINSON DISEASE

This program offers free continued treatment with BIA 28-6156 to people with Parkinson's disease who have a specific change in the GBA1 gene and have already finished the ACTIVATE study. The goal is to provide ongoing access to the study drug while monitoring safety and effects. …

This very early study is testing whether a new type of brain stimulation, delivered via electrodes placed on the brain's surface, can improve movement problems in people with Parkinson's disease. Only 3 adults with Parkinson's will take part. They will first have a non-invasive t…

This study tests an experimental drug called BIIB122 in 50 people with a specific genetic form of Parkinson's disease (LRRK2-PD). The goal is to check the drug's safety and how it affects certain markers in the body over 12 weeks. Participants are randomly assigned to receive eit…

This program offers early access to tavapadon, an investigational drug for Parkinson's disease, before it is officially approved. It is for people who have no other suitable treatment options and cannot join ongoing clinical trials. A doctor must decide if the potential benefits …

This study looks at how genetics and aerobic exercise together might slow the progression of Parkinson's disease. Two hundred people with Parkinson's will take part in a community-based cycling program three times a week for a year. Researchers will track motor symptoms and think…

This study tests whether dapansutrile, a drug that targets inflammation, is safe and can reduce brain and body inflammation in people with early Parkinson's disease. 36 participants will take the drug or a placebo daily for 6 months, with brain scans and spinal fluid tests to mea…

This study tests a new way to fine-tune deep brain stimulation (DBS) settings for people with Parkinson's disease who already have a DBS device. Researchers use each patient's brain scans to create a computer model and then find the best stimulation settings to improve walking an…

This study tests an experimental oral drug called HL-400 in 86 healthy adults aged 18-65. The drug aims to reduce inflammation linked to Parkinson's disease. The main goal is to check safety and how the drug moves through the body, not yet to treat the disease. This is an early-p…

This study tests whether BHV-8000 can slow the worsening of daily motor skills in people recently diagnosed with Parkinson's disease. About 550 adults aged 40-85 with early Parkinson's will receive either the drug or a placebo. The main goal is to see how long it takes for sympto…

This study tests whether montelukast, a common asthma medication, can help control symptoms of Parkinson's disease. Researchers will give the drug to 60 adults with Parkinson's who are already taking levodopa. The main goal is to see if montelukast improves movement, mood, and da…

This study tests a gene therapy called AAV2-GDNF for people with moderate Parkinson's disease. The treatment is delivered directly into the brain to help protect and repair cells that control movement. About 127 adults aged 45-75 will take part, and the study will compare the the…

This study tests whether vinpocetine, a drug that may improve blood flow in the brain, can safely reduce Parkinson's symptoms like tremor and stiffness. Researchers will enroll 60 adults aged 50 and older who already take levodopa for Parkinson's. The main goal is to see if the d…

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people with early-stage Parkinson's or isolated REM sleep behavior disorder (iRBD), a condition that often leads to Parkinson's. About 80 participants will wear a h…

This early-stage study tests a new medicine called LY4006896 in healthy people and those with Parkinson's disease. The main goal is to check if the drug is safe and how the body processes it. About 127 participants will receive either the drug or a placebo by IV. This is a first …

This study tests whether silymarin, a natural antioxidant found in milk thistle, can protect brain cells and help manage symptoms in people with Parkinson's disease. Fifty adults aged 45 to 65 who are already on standard Parkinson's medication will take silymarin alongside their …

This early-phase study tests a new treatment called NouvNeu001 in 5 adults with advanced Parkinson's disease. The main goal is to see if the therapy is safe and tolerable. Researchers will also check if it improves movement and non-movement symptoms over 96 weeks. Participants re…

This study tests an experimental drug called NEU-411 in 150 people aged 40-80 with early Parkinson's disease who have a specific genetic profile linked to the LRRK2 pathway. Participants will be randomly assigned to receive either NEU-411 or a placebo for about a year, with an op…

This early-stage trial tests whether transplanting a patient's own lab-grown brain cells is safe for Parkinson's disease. Researchers take skin cells, turn them into dopamine-producing nerve cells, and surgically place them into the brain. Only 8 people with moderate Parkinson's …

This study compares deep brain stimulation (DBS) plus medication against medication alone for Parkinson's patients who also have impulse control disorders like gambling or compulsive behaviors. About 60 participants will be randomly assigned to one of the two groups. The goal is …

This study follows 1000 people with movement disorders like Parkinson's disease, essential tremor, and dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects for up to 5 years. T…

This early-stage trial tests a gene therapy called IPS101A in 6 people with advanced Parkinson's disease (stages 4-5) whose symptoms are not well-controlled by current medications. The main goal is to check safety and find the best dose, while also looking for any signs of improv…

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started medication will be assigned to either moderate or high-intensity treadmill workouts four t…

This study tests whether adding etoricoxib, an anti-inflammatory drug, to standard Parkinson's treatment can reduce brain inflammation and improve symptoms. Researchers will enroll 60 adults with Parkinson's and measure changes in movement and daily function. The goal is to see i…

This study tests whether a daily nasal spray containing insulin and glutathione can safely improve thinking and movement in people with Parkinson's disease. About 56 adults with Parkinson's will receive either the active spray or a placebo for several months, while continuing the…

This study tests whether celecoxib, an anti-inflammatory drug, can improve symptoms in people with Parkinson's disease. Researchers believe brain inflammation plays a role in Parkinson's, and celecoxib may help control it. The trial will enroll 80 adults and measure changes in mo…

This study tests whether metformin, a standard diabetes drug, can safely improve movement and quality of life in people with Parkinson's disease. Researchers will give metformin or a placebo to 60 adults aged 50 and older who already take levodopa/carbidopa. The goal is to see if…

This study tests a new treatment for people with early-stage Parkinson's disease. It uses focused ultrasound to target a small area in the brain, aiming to improve movement problems. About 72 participants will either receive this ultrasound treatment or continue with standard med…

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain for years. The goal is to monitor long-term safety and carefully reduce the dose to avoid sudden withdrawal. Researchers will also help transition to an alternative treatment if n…

This study will test whether people with Parkinson's disease can stick to a Mediterranean-style diet for 18 months and whether it helps their gut health and symptoms. About 40 participants without dementia will be randomly assigned to either the special diet or a standard diet. R…

This study looks at whether tissue samples taken from the colon during a routine colonoscopy can find signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). Researchers will check for a protein called alpha-synuclein, which is linked to Parkinson's. The goal is to cat…

This study tests whether a smartphone app can record and analyze speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. Researchers will stu…

This study is testing a special PET scan (18F-DOPA) to see if it can better detect and measure several conditions, including congenital hyperinsulinism in children, neuroblastoma, neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. About 800 children…

This study is testing whether new PET/CT scans can detect a protein called alpha-synuclein in the brain, which is linked to Parkinson's disease and similar conditions. Researchers will scan 500 adults who have or are suspected to have Parkinson's. The goal is to see if these scan…

This study aims to develop computer models that can diagnose and monitor Parkinson's disease by analyzing eye movements, pupil reactions, and walking patterns. Researchers will collect data from 100 people with Parkinson's or similar conditions using special devices. The goal is …

This study looks at whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers want to see if a protein called alpha-synuclein is present in the colon of people with Parkinson's. The goal is to catch the disease earlier, before mo…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This study tests whether increasing daily physical activity using a motivational smartphone app can slow cognitive decline in people with a sleep disorder that often leads to Parkinson's disease. Researchers will enroll 130 participants (80 with the sleep disorder and 50 healthy …

This study tests whether a telerehabilitation program using a virtual reality (VR) app can improve thinking skills and social abilities in people with mild memory problems. About 480 adults aged 40-80 with subjective cognitive decline or mild cognitive impairment will use VR exer…

This study tests whether fexofenadine, a common allergy medication, can improve quality of life for people with Parkinson's disease who are already on standard treatment. Researchers will enroll 46 adults aged 50 and older with mild to moderate Parkinson's. The goal is to see if …

This study tests whether training with a metronome—using slow beats on a treadmill and fast beats while walking on the ground—can improve how people with Parkinson's disease walk. Over 12 one-hour sessions, 45 participants will practice stepping to different speeds and have their…

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking improvements in 150 participants, including hea…

This study tests whether a home-based, virtually-supervised exercise program combining high-intensity endurance and resistance training is safe and feasible for people with Parkinson's disease. Researchers will also measure if the exercise improves cognitive function and motor sy…

This study tests a new nasal spray called XJN010 for people with Parkinson's disease who have 'off' episodes—times when their regular medication stops working and symptoms return. The trial will include 84 adults aged 30 to 85 who have had Parkinson's for at least 3 years. Resear…

This study tests a wearable device that gives feedback on swallowing muscle activity to help people with swallowing problems from stroke or Parkinson's disease. About 120 adults aged 50-90 will do a 12-week therapy program either in-person or at home via telehealth. The goal is t…

This study tests a new therapy for Parkinson's disease where patients watch their own 3D motion recordings in a fully immersive virtual reality environment. The goal is to see if this 'action observation training' can improve slow movement (bradykinesia) and other symptoms. The s…

This study looks at how well the drug opicapone works for people with Parkinson's disease who have early motor fluctuations. Researchers will follow 200 patients in Italy for 12 months to see if their symptoms improve. The goal is to understand the drug's effectiveness and safety…

This study looks at how well the drug Foslevodopa/Foscarbidopa works for Italian adults with advanced Parkinson's disease in everyday medical practice. About 270 participants will receive the drug as a continuous infusion under the skin for up to 12 months. The main goal is to se…

This study tests whether adding visual feedback exercises—using a laser pointer to guide trunk and leg movements—to standard physical therapy can improve balance and daily activities in people with Parkinson's disease. Researchers will enroll 32 adults with mild to moderate Parki…

This study tests a smartphone app designed to help people with Huntington's or Parkinson's disease feel less anxious. The app works by training users to interpret everyday situations in a less threatening way. Researchers will enroll 136 participants to see if the app improves an…

This study tests whether mild electrical stimulation to the brain and spine can boost the effects of walking and balance exercises in people with Parkinson's disease who have trouble with falls and unsteady gait. About 71 participants (51 with Parkinson's and 20 healthy volunteer…

This study tests whether a new type of deep brain stimulation (called adaptive DBS) can safely improve walking and balance problems in people with Parkinson's disease. The device adjusts stimulation in real time based on brain activity and what the person is doing (like sitting o…

This study tests whether a daily tributyrin supplement (taken 3 times a day for about 3 months) can improve memory, thinking, walking, and balance in adults with Parkinson's disease who also have mild cognitive impairment or dementia. Researchers will compare tributyrin to a plac…

This study tests a new, non-invasive brain stimulation called accelerated Temporal Interference Stimulation (TIS) to see if it can improve movement and speech in people with Parkinson's disease. About 60 participants will receive either real TIS or a sham (fake) treatment for 5 d…

This study looks at whether a new type of deep brain stimulation (called patterned DBS) is safe and tolerable for people with Parkinson's disease when used at home. About 60 adults who already have a DBS device will try the new stimulation pattern for two weeks. The goal is to se…

This study tests whether a daily probiotic can reduce depression symptoms in people with Parkinson's disease. 60 participants will take either a multi-strain probiotic or a placebo for 12 weeks. Researchers will measure mood changes using standard depression questionnaires. The g…

This study looks at two different exercise plans for veterans with moderate Parkinson's disease. One group exercises a lot for one week, then rests for three weeks. The other group exercises every week without breaks. Researchers will measure walking speed, daily activity levels,…

This study tests whether doing fast bodyweight exercises at home, guided remotely by a physiotherapist, can reduce bradykinesia (slowness of movement) in people with Parkinson's disease. 46 participants aged 50+ with mild to moderate Parkinson's will be randomly assigned to eithe…

This study tests a new type of brain stimulation electrode (CARTESIA™) in 10 people with Parkinson's disease. The goal is to see if using directional stimulation can improve motor symptoms and reduce side effects compared to standard ring-mode stimulation. Participants already ha…

This study tests whether the drug varenicline can reduce falls and improve the ability to walk while doing another task in people with Parkinson disease. About 102 participants will receive either varenicline or a placebo for one year. The study uses walking tests, brain imaging,…

This small pilot study tests whether a fast, repeated form of brain stimulation (accelerated TMS) can safely reduce apathy—a common and troubling symptom—in people with Parkinson's disease. Fifteen participants will receive 48 stimulation sessions over two weeks, with follow-up a…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve walking and other motor skills in people with progressive supranuclear palsy, corticobasal syndrome, or Parkinson's disease. Twenty participants will receive both real and sham stimulation…

This study looks at whether supervised pool exercises can improve daily activities, walking, balance, posture, pain, and depression in people with Parkinson's disease. Forty-two adults aged 40-80 with mild to moderate Parkinson's will be split into two groups: one doing home exer…

This study tests a new, non-invasive method using light, sound, and touch to stimulate gamma brain waves in people with mild Parkinson's disease. The goal is to see if it's safe and can change brain activity. Forty participants will have their brain waves measured before, during,…

This study tests whether adding AP-472 to standard levodopa treatment can reduce the daily time when Parkinson's symptoms return (OFF time) in people with motor fluctuations. About 150 adults aged 30-80 with mild to moderate Parkinson's will take either a low dose, high dose, or …

This study looks at whether using a CPAP machine (commonly used for sleep apnea) can lower high blood pressure when lying down at night and help with dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like Parkinson's disease or m…

This study tests whether a new form of deep brain stimulation that adapts in real time (aDBS) works better than the standard continuous stimulation (cDBS) for people with Parkinson's disease. About 130 adults who already have a brain pacemaker implanted will be randomly assigned …

This study tests a non-invasive nerve stimulation method (RAVANS) to see if it can improve apathy—a common lack of motivation—in people with Parkinson's disease. Sixty participants will receive either real or sham stimulation for two weeks. Researchers will measure changes in mot…

This study tests if special rotational exercises can reduce fall risk and improve mobility in people with Parkinson's disease. Researchers will enroll 50 participants aged 50-70 with mild to moderate Parkinson's. The exercises focus on turning movements, which are often difficult…

This study looks at whether doing high-intensity aerobic exercise before virtual reality training can improve balance and help the brain adapt in people with Parkinson's disease. Sixteen participants will be split into two groups: one does aerobic exercise plus VR, the other does…

This study tests whether pyridostigmine, a drug that boosts nerve signals, can help with constipation in people with Parkinson disease. Constipation is a common and frustrating symptom that often starts years before movement problems. The trial will measure changes in bowel movem…

This study tests whether an online self-management program or in-person task training helps people with early-stage Parkinson's disease do daily activities and feel better. About 100 adults aged 45-70 will be split into three groups: online program, in-person training, or no extr…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve cognitive problems and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's disease. Researchers will give TMS to the …

This study is testing whether combining physical exercise with a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can improve walking, balance, and reaction time in people with Parkinson's disease. Researchers will enroll 100 …

This study tests a temporary spinal cord stimulation device to help people with advanced Parkinson's disease who experience freezing of gait—a sudden inability to move their feet. Researchers will place small electrodes near the spine to see if it improves walking and reduces fal…

This study is testing a remote coaching program called Engage-Qatar PD to help people with Parkinson's disease in Qatar become more physically active. The program is designed to be used online and tailored to the local culture. Researchers will work with 40 participants to see if…

This study looks at how different types of exercise—like cardio, strength training, or a mix of both—affect sleep quality in people with Parkinson's disease. Researchers will track 150 participants over 12 weeks, measuring sleep with both sleep lab tests and questionnaires. The g…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce impulse control disorders in people with Parkinson's disease who are on dopamine replacement therapy. Twenty participants will each receive both real and sham (fake) stimulation in random o…

This early-phase study tests whether using a special standing desk that moves slightly (dynamic standing) can improve walking and motor symptoms in people with Parkinson's disease. Five participants will attend 12 four-hour sessions comparing dynamic standing, static standing, an…

This early study tests whether electrical spinal cord stimulation is safe for Parkinson's patients who have painful camptocormia, a condition where the trunk bends forward severely when standing or walking. Six participants will receive the stimulation device and be monitored for…

This study tests an experimental drug called HBI-002, a low-dose carbon monoxide liquid taken by mouth daily for 14 days. It aims to see if the drug is safe and tolerable in 36 adults aged 40-80 with Parkinson's disease. Participants are randomly assigned to receive the drug or a…

This study looks at whether a 12-month home exercise program can help thinking skills in people with Parkinson's disease who also have mild memory or attention problems. About 150 adults aged 30–80 will either do moderate-to-vigorous aerobic exercise at home or continue their usu…

This study tests a non-invasive device that stimulates the spinal cord through the skin to improve walking and balance in people with Parkinson's disease. The treatment targets movement problems that don't respond well to standard medications. Twenty adults with Parkinson's will …

This study tests whether adding motor imagery—a safe mental practice where you imagine doing movements like walking or standing—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. About 42 adults aged 40+ with mild to m…

This study tests if a precise radiation treatment called stereotactic radiosurgery can reduce tremors and improve quality of life for people with essential tremor or Parkinson's disease whose medications aren't working well enough. About 60 adults will receive the treatment and t…

This study tests whether following a Mediterranean diet for three months after deep brain stimulation surgery helps Parkinson's patients manage weight and improve body composition. About 24 adults aged 45-64 will be randomly assigned to either receive Mediterranean diet guidance …

This study tests whether real-time visual feedback from the SpiroGym mobile app makes breathing muscle training more effective for people with Parkinson's disease. Researchers will compare training with and without the app's feedback in 30 participants. The goal is to see if the …

This study tests a gentle brain stimulation method called tDCS to see if it can improve thinking and memory in people with Parkinson's disease who have mild cognitive issues. About 36 adults with Parkinson's will receive tDCS or a sham treatment, and their cognitive performance w…

This study follows 120 people with Parkinson's disease who are using a continuous apomorphine infusion pump (ONAPGO). Researchers will track how long it takes to find the right dose and how the pump affects daily symptoms and caregiver burden. The goal is to understand real-world…

This study tests whether adding low-frequency stimulation to the standard high-frequency deep brain stimulation (DBS) can improve Parkinson's motor symptoms while reducing side effects like depression, impulsivity, and thinking problems. Ten adults with Parkinson's who already ha…

This study tests whether turning on an extra deep brain stimulation (DBS) electrode in a brain region called the GPe can improve severe insomnia in people with Parkinson's disease. Ten participants aged 40-80 with Parkinson's for 7-20 years and severe insomnia will be enrolled. T…

This study tests a new therapy called CereGate for people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. The therapy is used alongside their existing deep brain stimulation and medication. Researchers will measure c…

This study tests a device called Cue2Walk that automatically detects when people with Parkinson's disease freeze up while walking and provides rhythmic cues to help them keep moving. Researchers will compare the device to usual care in 84 participants to see if it improves qualit…

This study explores whether listening to personalized music can help reduce apathy (lack of motivation and emotion) in people with Parkinson's disease. Researchers will use brain scans to see how music affects areas linked to reward and movement. 50 adults with Parkinson's will l…

This study looks at whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can help people with Parkinson's disease improve their balance and reduce falls. Researchers will give high-frequency magnetic pulses to the brain and measure stability…

This study tests a new therapy to improve coughing and swallowing in people with Parkinson's disease, aiming to prevent pneumonia—a leading cause of death. Researchers will compare the same treatment given in-person or via telehealth to see which works better. About 120 participa…

This study tests whether a gentle, MRI-guided electrical brain stimulation (called mgTDCS) can improve depression, apathy, and working memory in people with Parkinson's disease. About 40 participants with Parkinson's and elevated depression will receive either real or sham stimul…

This study tests a new way to help people with Parkinson's improve their balance and reduce falls. Participants will play exercise video games while getting feedback on their brain activity to see if this combination works better than exercise alone. The study involves 100 people…

This study tests whether a continuous apomorphine pump can reduce muscle stiffness and improve comfort for people with advanced Parkinson's disease who are nearing the end of life. About 80 participants who are already receiving home hospital care will be enrolled. The goal is to…

This study observes 90 adults with Parkinson's disease who are starting SL-APO, a medication taken as needed for OFF episodes (when symptoms return between doses). Researchers will track how doctors adjust the dose over time and how this affects patient satisfaction and treatment…

This study tests a speech therapy and counseling program designed for Korean immigrants with Parkinson's disease who have trouble speaking clearly (dysarthria). About 32 patients and their caregivers will receive culturally tailored therapy online. The goal is to see if this appr…

This study tests whether a non-invasive brain stimulation technique called patterned repetitive transcranial magnetic stimulation (prTMS) can reduce bradykinesia (slowness of movement) in people with Parkinson's disease. Researchers will compare active stimulation to a sham (fake…

This study tests whether adding musical sound cues to standard walking therapy helps people with Parkinson's disease, stroke, or multiple sclerosis walk better and feel less tired. About 120 adults will either get standard rehab or rehab with these sound cues. The goal is to see …

This study is testing whether a non-invasive technique called transcranial ultrasound stimulation (TUS) can safely improve thinking, movement, and quality of life in people with neurodegenerative diseases like Parkinson's and Alzheimer's. Twenty adults aged 18-80 with these condi…

This study looks at how bacteria in your gut might be linked to brain aging and diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will compare 200 people—healthy young and older adults, plus those with early Alzheimer's, Parkinson's, or MS—using brain sc…

This study aims to find new biological markers for diseases like Alzheimer's, Parkinson's, and ALS by analyzing the genes, proteins, and metabolism of 1,200 patients. Researchers will use advanced technology to look for patterns that could help with earlier diagnosis, better prog…

This study aims to understand how certain brain signals (beta waves) relate to movement problems in Parkinson's disease. Researchers will work with 25 people already scheduled for deep brain stimulation (DBS) surgery. By using special stimulation and medication, they hope to lear…

This study follows 100 people with Parkinson's disease who visit a special clinic offering complementary treatments like homeopathy, herbal medicine, hypnosis, and lifestyle advice alongside their regular care. Researchers will track changes in symptoms and well-being using stand…

This study aims to understand how inflammation in the brain contributes to Parkinson's disease. Researchers will give a mild inflammatory substance (LPS) to 30 participants, including people with Parkinson's, those with REM sleep behavior disorder, and healthy volunteers. They wi…

This study tests whether a small vibrating device worn on the body can help people with Parkinson's disease walk more automatically and steadily. Sixty participants will be randomly assigned to receive either personalized vibrations timed to each step or fixed-interval vibrations…

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will check if the Italian version works well by testing it with 190 patients across multiple centers. The goal is to help doctors better …

This large observational study follows 4,500 people, including those with Parkinson's, those at risk, and healthy volunteers, to track how the disease progresses. Researchers collect clinical, imaging, and genetic data to identify markers that could help design better treatments.…

This study looks at whether letting people with Parkinson's disease choose when they get feedback helps them learn new motor skills. 72 participants will practice a finger-pressing task, with one group having control over feedback and the other not. Researchers will measure accur…

This study aims to understand why some people with Parkinson's disease experience freezing of gait—a sudden inability to move their feet. Researchers will use special brain recordings from implanted DBS devices to compare brain activity in people with and without freezing. The go…

This study aims to create a large national collection of blood samples and medical data from 230 people with Parkinson's disease or a related sleep disorder. Researchers will analyze the complete genetic code of participants to find rare gene changes that may cause or contribute …

This study aims to understand the brain activity behind risk-taking and reward-seeking behaviors in people with Parkinson's disease. Researchers will record brain signals during deep brain stimulation (DBS) surgery while participants play a gambling task. The goal is to learn how…

This study is following 2950 people, including healthy individuals and those with memory or movement problems, to learn more about brain diseases like Alzheimer's and Parkinson's. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve di…

This study looks at how the brain handles sensory information in people with Parkinson's disease. Researchers will measure brain activity and arm movements in 30 participants during and after deep brain stimulation surgery. The goal is to understand the brain's role in movement p…

This study aims to learn how Parkinson's disease affects Black and African American people by collecting genetic and health information from 2,000 participants aged 50 and older. Researchers will compare those with and without Parkinson's to find genetic risk factors unique to th…

This study looks at how balance problems, walking difficulties, physical activity levels, and sleep quality are connected in people with Parkinson's disease. Researchers will compare 34 participants with Parkinson's to healthy adults of similar age to see which issues are due to …

This study uses special PET scans to measure brain inflammation in people with early or suspected Parkinson's disease and in healthy volunteers. Researchers will compare scans taken at the start, after 12 months, and after 24 months to see how inflammation changes over time. The …

This study looks at whether listening to a steady beat (like a metronome) can improve walking in people with Parkinson's disease who have a brain implant (deep brain stimulation). Ten participants will walk while the beat plays, and researchers will measure their walking speed, s…

This study aims to understand why some people with Parkinson's disease experience central pain by examining the serotonin system in the brain. Researchers will use PET and MRI scans on 34 participants to measure serotonin receptors and brain connectivity. The goal is to gather kn…

This study creates a registry to collect safety and effectiveness information on ambroxol, a common cough medicine, when used off-label at higher doses for Gaucher disease or GBA-related Parkinson's. Researchers aim to gather data from 300 patients worldwide to help doctors and f…

This study aims to find early biological markers for Parkinson's disease and similar brain disorders by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people—including those with Parkinson's, multiple system atrophy, Lewy body dementi…

This study is screening 2,000 people aged 50 to 99 who do not have Parkinson's disease but may have early risk signs. Researchers will follow participants for five years to track changes in movement and other symptoms. The goal is to better understand how Parkinson's develops and…

This study uses special brain scans (PET, SPECT, and MRI) to learn more about the brain changes that happen in Parkinson's disease. Researchers want to find a biological marker that could help develop new medicines to slow down the disease. The study involves 42 adults aged 25 to…

This study uses special brain scans (PET, SPECT, and MRI) to find markers of Parkinson's disease in people with certain genetic mutations. Researchers will look at changes in brain chemicals and structure to better understand the disease. The goal is to help develop new treatment…

This study is building a research database of people with Parkinson's disease and related conditions. Researchers will collect medical history, symptoms, brain images, and biological samples to learn about the long-term effects and genetic factors of the disease. Up to 250 partic…

This study is observing 280 people with Parkinson's disease or multiple system atrophy to understand how pain and automatic body functions (like sweating, digestion, and heart rate) affect their daily lives. Researchers will track symptoms before and after a rehabilitation progra…

This study looks at how the brain controls movement in people with Parkinson's disease. During planned deep brain stimulation (DBS) surgery, researchers will place a thin strip on the brain's surface to record electrical signals. The goal is to learn how different brain areas tal…

This study uses a non-invasive brain stimulation technique called TMS to measure brain activity in 52 people with Parkinson's disease. The goal is to see if these measurements can tell the difference between normal thinking, mild cognitive impairment, and dementia, and predict fu…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with brain conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based tests with standard in-p…

This study looks at how the brain works in 30 people with Parkinson's disease who are scheduled for Deep Brain Stimulation (DBS) surgery. Researchers want to understand brain signals related to movement and thinking to make DBS therapy more effective in the future. Participants w…

This study looks at brain signals recorded during Deep Brain Stimulation (DBS) surgery for Parkinson's disease. Researchers want to understand how DBS changes brain activity and use that information to better target electrodes and program the device. About 36 adults with advanced…

This study aims to find out how common functional neurological disorders are in people who already have a movement disorder like Parkinson's disease, tremor, or dystonia. Researchers will examine 216 adults aged 18 to 80 using neurological exams, thinking tests, and questionnaire…

This study uses a special PET scan to measure brain inflammation in people with Parkinson's disease compared to healthy volunteers. Researchers want to see if inflammation levels are higher in Parkinson's and how they relate to symptoms. About 205 participants will be scanned and…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep condition called REM sleep behavior disorder. Researchers will use overnight sleep tests to compare sleep quality among these groups and healthy volunteers. The goal is to better understa…

This study looks at how the placement and strength of deep brain stimulation (DBS) in the brain affects a person's ability to stop themselves from acting impulsively. Researchers will test 80 people with Parkinson's disease and healthy volunteers using computer tasks that measure…

This study aims to develop better ways to measure how much energy people with Parkinson's use during dance classes. Researchers will use cameras, wearable activity monitors, and questionnaires to track dance intensity and link it to daily activities and health. About 60 adults wi…

This study is looking for ways to improve how doctors diagnose Parkinson's disease and similar conditions like multiple system atrophy and progressive supranuclear palsy. Researchers will use brain scans and artificial intelligence to find patterns that can tell these diseases ap…

This study looks for easy ways to detect early signs of multiple sclerosis and Parkinson's disease in drivers. Researchers will test 200 drivers with these conditions using computer-based tasks that measure attention, reaction time, and impulse control. The goal is to find simple…

This study looks at how blood pressure changes when standing up affect thinking and blood flow in the brain for people with Parkinson's disease. About 60 participants, some with and some without low blood pressure upon standing, will take thinking tests while lying down and stand…

This study looks at how deep brain stimulation (DBS) changes brain activity and movement in people with conditions like Parkinson's disease and essential tremor. About 60 people scheduled for DBS surgery will have temporary brain recordings during their procedure. The goal is to …

This study looks at why some people with Parkinson's disease experience thinking problems after deep brain stimulation (DBS). Researchers will scan the brains of 55 participants with DBS implants to see how stimulation changes brain networks. The goal is to help doctors choose be…

This study looks at how different types of treadmill training affect the gut bacteria and symptoms of people with Parkinson's disease. Sixty participants will be split into three groups: one doing standard physical therapy, one using a special treadmill (C-Mill), and one using th…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study looks at how Parkinson's disease changes the brain's ability to control actions, like stopping or switching tasks. Researchers will have 50 people with Parkinson's do joystick tasks to measure their reaction times and accuracy. The goal is to understand these problems …

This study is testing a digital system that helps people with Parkinson's track and manage non-motor symptoms like pain, mood, and sleep problems. 30 people with Parkinson's and their care partners will use the tool for 6 months. The goal is to see if it's easy to use and helps p…

This study looks at brain activity related to non-motor symptoms like depression and attention problems in people with Parkinson's disease. Researchers will record brain surface signals during routine deep brain stimulation (DBS) surgery. About 140 participants who are already sc…

This study looks at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants will receive either a small amount of alcohol or a non-alcoholic drink on two separate days, and researchers will measure their tremor before and af…

This study looks at why some people with Parkinson's disease suddenly freeze while walking or turning. Researchers will use gentle electrical stimulation and brain wave recordings to understand the brain and balance systems involved. The goal is to find clues that could lead to b…

This study looks at how different levels of deep brain stimulation affect sleep in people with Parkinson's disease. Ten participants will try three stimulation settings over six weeks while their sleep and brain activity are monitored. The goal is to find which setting helps them…

This study looks at how deep brain stimulation (DBS) helps with walking problems in people with Parkinson's disease that don't get better with medication. About 36 adults who already have a DBS device will be monitored during daily activities using a smartphone app and the device…

This study looks at how deep brain stimulation (STN-DBS) changes speech in people with Parkinson's disease who also have impulse control issues. Researchers will record voices of 60 participants before and after treatment to measure changes in clarity, emotion, and meaning. The g…

This study is gathering information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are already scheduled to receive radiofrequency (RF) ablation as part of their routine care. The goal is to see how this treatment affects qua…

This study looks at how brain activity and thinking skills (like attention and planning) affect walking in people with Parkinson's disease and healthy older adults. Researchers will measure walking patterns, brain waves, and thinking tests in 70 participants. The goal is to bette…

This study looks at how two drugs, midodrine and droxidopa, affect the veins in the abdomen of people with autonomic failure—a condition where the body can't control blood pressure properly. About 34 adults aged 40-80 with conditions like Parkinson's disease or multiple system at…

This study tests whether small motion sensors can objectively detect internal tremors—shaky feelings inside the body—in people with Parkinson's disease. Researchers will compare readings from 30 Parkinson's patients and 30 healthy volunteers to see if a specific 4-6 Hz signal is …

This study aims to find a biological marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI). Researchers will track 44 participants over time to see how certain brain cells and chemicals change as the disease progresses. The goal is to better understand…

This study observes brain activity related to speech in 80 people with Parkinson's disease, essential tremor, or dystonia who are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record electrical signals from brain regions involved in speech while par…

This study aims to better predict how dementia will progress in individuals with mild cognitive impairment or early dementia. Researchers will collect blood samples and use computer models to track changes in thinking and memory over time. The goal is to improve prognostic confid…

This study looks at how Parkinson's disease changes social behavior and quality of life. Researchers will compare 500 adults with Parkinson's to healthy adults of the same age. The goal is to understand challenges in daily living, mental health, and thinking skills, without offer…

This study looks at why many people with Parkinson's disease crave sugary foods and whether eating fast-acting sugars improves their symptoms. Researchers will give 50 participants a sugar drink and a placebo on different days, measuring insulin, blood sugar, and movement. The go…

This study will review the medical records of up to 5,000 people who have or are eligible for deep brain stimulation (DBS) to treat Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in everyday medical practice. N…

This study follows 150 people with early-stage Parkinson's disease to see how symptoms like walking problems and thinking changes differ between two newly identified types: 'brain-first' and 'body-first.' Researchers will use brain scans, movement tests, and other assessments ove…

This study is testing whether a new, low-cost brain scan can find early signs of Alzheimer's and Parkinson's disease. Researchers will compare brain scans from 120 people, including those at risk for Alzheimer's, those with Parkinson's, and healthy volunteers. The goal is to deve…

This study looks at how Parkinson's disease impacts breathing, inspiratory muscle strength, physical fitness, and aerobic capacity. Researchers will compare 100 people with Parkinson's (ages 50-80) to healthy volunteers of similar age. Participants undergo breathing tests, fitnes…

This study aims to learn more about the brain activity that causes thinking and memory problems in people with Parkinson's disease. Researchers will record brain signals during deep brain stimulation surgery in 75 participants. The goal is to understand how certain brain areas wo…

This study looks at whether changing the amount of carbidopa relative to levodopa in Parkinson's medication can reduce a common side effect: a sudden drop in blood pressure when standing up (orthostatic hypotension). It includes 36 adults with Parkinson's disease or multiple syst…

This observational study looks at whether taking immunosuppressive drugs for other conditions can slow the onset or progression of Parkinson's disease. Researchers will compare 80 people with Parkinson's—half on long-term immunosuppressants, half not—by measuring motor symptoms a…

This study aims to understand how brain cells work when people with Parkinson's disease perform thinking tasks. Researchers will insert a thin probe into the brain for a short time during planned deep brain stimulation surgery. The goal is to learn more about brain function, not …