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Parkinson's inflammation mystery: brain scans after mild immune trigger

NCT ID NCT05205291

Recruiting now Knowledge-focused Sponsor: University of Exeter Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand how inflammation in the brain works in Parkinson's disease. Researchers will give a mild inflammatory compound (LPS) to 30 volunteers—some with Parkinson's, some with a sleep disorder linked to Parkinson's, and some healthy—and use special PET-MR brain scans to see how the brain's immune cells respond. The goal is to learn more about the role of inflammation in Parkinson's, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Lipopolysaccharide (LPS) and [11C]PBR28 tracer
What this could lead to
If successful, this could help explain how inflammation contributes to Parkinson's disease, potentially pointing toward new treatment targets.
What could go wrong
This is a very early, small study (30 people) focused on understanding mechanisms, not testing a treatment. The findings may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation neurodegenerative disease Parkinson disease REM sleep behavior disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEURODEGENERATIVE DISEASES PARKINSON DISEASE REM SLEEP BEHAVIOR DISORDER (IRBD)

Contacts and locations

Locations

  • University of Exeter

    RECRUITING

    Exeter, United Kingdom

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