REM SLEEP BEHAVIOR DISORDER (IRBD)

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people with early-stage Parkinson's or isolated REM sleep behavior disorder (iRBD), a condition that often leads to Parkinson's. About 80 participants will wear a h…

This study tests a 4-week online course that teaches people how to manage parasomnias—unwanted events during sleep like sleep terrors, sleepwalking, and nightmares. The course provides education and self-management guidance. Researchers will measure if the course reduces how ofte…

This study aims to understand how inflammation in the brain contributes to Parkinson's disease. Researchers will give a mild inflammatory substance (LPS) to 30 participants, including people with Parkinson's, those with REM sleep behavior disorder, and healthy volunteers. They wi…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep condition called REM sleep behavior disorder. Researchers will use overnight sleep tests to compare sleep quality among these groups and healthy volunteers. The goal is to better understa…

This study looks at pain in people with idiopathic REM sleep behavior disorder (iRBD), a condition that often leads to Parkinson's disease. Researchers will compare pain levels in 24 participants with iRBD to a control group with narcolepsy and similar sleep issues. The goal is t…

This study follows 650 people with early Parkinson's disease or a sleep disorder called iRBD to track how the disease progresses over time. Researchers use brain scans, heart tests, and spinal fluid samples to find markers that predict changes in movement, thinking, and daily lif…

This study uses a new, ultra-detailed PET scanner to see very small brain structures in healthy aging and in conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. Researchers will scan 300 volunteers and patients to find early signs of disease and create detaile…