University Of Exeter

This study looks at whether adding a structured exercise program to the weight-loss drug tirzepatide can help overweight and obese women maintain muscle mass and physical function. Sixty women aged 25-50 will take tirzepatide for 20 weeks; half will also follow a progressive resi…

This study uses special brain scans to measure damage to nerve connections in people with Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP). Researchers will scan 36 adults aged 45-80 to see how the disease changes over time. The goal is to better understand …

This study looks at people with rare genetic changes that affect beta cells, which control blood sugar. Researchers will collect blood samples and optional MRI scans to find biomarkers and understand how these genes change body function. No treatment is given, and participants co…

This study looks at babies diagnosed with type 1 diabetes before age 2, a rare and extreme form of the disease. Researchers want to understand what goes wrong in the immune system to cause such early onset. By studying these children and comparing them to others with diabetes and…

This study uses advanced brain scans (PET, SPECT, and MRI) to find markers of Parkinson's disease in people with certain genetic mutations. Researchers will look at changes in brain chemicals and structure. The goal is to better understand the disease and help develop new treatme…

This study aims to understand how inflammation in the brain works in Parkinson's disease. Researchers will give a mild inflammatory compound (LPS) to 30 volunteers—some with Parkinson's, some with a sleep disorder linked to Parkinson's, and some healthy—and use special PET-MR bra…

This study uses special brain scans (PET, SPECT, and MRI) to look for a marker that shows how Parkinson's disease changes over time. Researchers will scan 44 people with Parkinson's to see if a compound called BU99008 can highlight brain cell activity linked to the disease. The g…

This study uses advanced brain scans (PET and MRI) to examine serotonin activity in people with Parkinson's disease. Researchers will compare brain images from 42 participants at different stages of the disease. The goal is to find biological markers that could lead to new treatm…

This study tests whether a plant-based, protein-dense sauce (ProSauce) helps older adults absorb essential amino acids better than a standard low-protein sauce, without making them feel too full. Twenty healthy adults aged 60 and over will eat two test meals in random order, and …