Weight loss drug plus exercise may protect muscle in women

NCT ID NCT07457437

Recruiting now Disease control Sponsor: University of Exeter Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding a structured exercise program to the weight-loss drug tirzepatide can help overweight and obese women maintain muscle mass and physical function. Sixty women aged 25-50 will take tirzepatide for 20 weeks; half will also follow a progressive resistance exercise routine. The goal is to see if exercise prevents muscle loss during weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide (a weight-loss drug) and a progressive resistance exercise program
What this could lead to: If it works, this could show that combining exercise with tirzepatide helps women lose fat while preserving muscle and strength, leading to better overall health.
What could go wrong: This is a small, early-stage study with only 60 participants. The exercise program is supervised and may not reflect real-world results. Tirzepatide can cause side effects like nausea and vomiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MUSCLE MASS AND STRENGTH are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUSCLE MASS AND STRENGTH OBESITY & OVERWEIGHT PHYSICAL FUNCTION

Contacts and locations

Locations

Nutritional Physiology Research Unit
RECRUITING

Exeter, Devon, EX2 4TH, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.