Weight loss drug plus exercise may protect muscle in women
NCT ID NCT07457437
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether adding a structured exercise program to the weight-loss drug tirzepatide can help overweight and obese women maintain muscle mass and physical function. Sixty women aged 25-50 will take tirzepatide for 20 weeks; half will also follow a progressive resistance exercise routine. The goal is to see if exercise prevents muscle loss during weight loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tirzepatide (a weight-loss drug) and a progressive resistance exercise program
What this could lead to
If it works, this could show that combining exercise with tirzepatide helps women lose fat while preserving muscle and strength, leading to better overall health.
What could go wrong
This is a small, early-stage study with only 60 participants. The exercise program is supervised and may not reflect real-world results. Tirzepatide can cause side effects like nausea and vomiting.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Nutritional Physiology Research Unit
RECRUITINGExeter, Devon, EX2 4TH, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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