Can one avocado a day sharpen the aging brain?

NCT ID NCT07752225

Not yet recruiting Disease control Sponsor: Maastricht University Medical Center Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This study tests whether eating one avocado daily for 12 weeks can improve blood flow to the brain and support heart and blood vessel health in adults with prediabetes and overweight or obesity. Researchers will measure brain blood flow using MRI, along with markers of blood vessel function, insulin sensitivity, cognition, and well-being. The trial involves 34 men and women aged 40–75 in a crossover design, meaning each participant will experience both the avocado and control periods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Avocado (one per day for 12 weeks)
What this could lead to: If daily avocado intake improves blood flow to the brain and heart health, it could point toward a simple dietary strategy to support brain and vascular function in people at risk for diabetes.
What could go wrong: This is a small, early-stage trial with only 34 participants, so results may not apply broadly. The effects could be modest or not significant, and the study does not test long-term health outcomes.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN HEALTH BRAIN INSULIN SENSITIVITY CEREBRAL BLOOD FLOW FOOD REWARD OBESITY & OVERWEIGHT PREDIABETES SATIETY AND FOOD INTAKE VASCULAR FUNCTION

Contacts and locations

Locations

Department of Nutrition and Movement Sciences

Maastricht, Limburg, 6200MD, Netherlands

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