Can a single pill tackle both fatty liver and diabetes?

NCT ID NCT05623189

Completed Disease control Sponsor: HighTide Therapeutics (Hong Kong) Limited Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests an experimental oral drug called HTD1801 in adults with nonalcoholic steatohepatitis (NASH), a serious liver condition, along with liver fibrosis and type 2 diabetes or prediabetes. Participants receive either HTD1801 or a placebo to see if the drug can improve liver health, such as reducing liver fat and inflammation without worsening scarring. The study aims to find out whether this treatment could offer a new option for managing both liver and metabolic problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HTD1801, an experimental oral drug taken as capsules
What this could lead to: If successful, this could point toward a new treatment that slows or reverses liver damage in people with NASH and diabetes.
What could go wrong: This is an early-stage trial, so the drug may not work as hoped or could cause side effects. Results need confirmation in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NONALCOHOLIC STEATOHEPATITIS (NASH) TYPE 2 DIABETES

Contacts and locations

Locations

Adobe Clinical Research LLC

Tucson, Arizona, 85712, United States
Aizona Liver Health

Tucson, Arizona, 85712, United States
Arizona Liver Health - Glendae

Peoria, Arizona, 85381, United States
California Liver Institute

Pasadena, California, 91105, United States
Catalina Research Institute

Montclair, California, 91763, United States
Chinese University of Hong Kong Prince of Wales Hospital

Shatin, Hong Kong
ClinCloud LLC Maitland

Maitland, Florida, 32751, United States
ClinCloud LLC Melbourn

Viera, Florida, 32940, United States
ClinSearch LLC

Chattanooga, Tennessee, 37421, United States
Clinical Pharmacology of Miami, LLC

Miami, Florida, 33014, United States
Clinical Research Institute of Ohio

Westlake, Ohio, 44145, United States
Clinnova Research Solutions

Garden Grove, California, 92845, United States
Conquest Research

Winter Park, Florida, 32789, United States
Covenant Metabolic Specialists - Fort Meyers

Fort Myers, Florida, 33912, United States
Covenant Metabolic Specialists - Sarasota

Sarasota, Florida, 34240, United States
EPIC Medical Research

DeSoto, Texas, 75154, United States
Evolution Clinical Trials, Inc.

Hialeah Gardens, Florida, 33016, United States
Excel Medical Clinical Trials, LLC

Boca Raton, Florida, 33434, United States
FDI Clinical Research

San Juan, Munoz Rivera San Juan, 00927, Puerto Rico
Floridain Clinical Research

Miami Lakes, Florida, 33016, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Impact Research Institute

Waco, Texas, 76710, United States
Inland Empire Liver Foundation

Rialto, California, 92377, United States
Jubilee Clinical Research, Inc.

Las Vegas, Nevada, 89106, United States
Liver Institute NW

Seattle, Washington, 98105, United States
Louisvill Metabolic and Atherosclerosis Research Center (L-MARC)

Louisville, Kentucky, 40213, United States
Lucas Research - Diabetes and Endocrinology

Morehead City, North Carolina, 28557, United States
Manassas Clinical Research Center

Manassas, Virginia, 20110, United States
Metabolic Research Institute, Inc.

West Palm Beach, Florida, 33401, United States
Palmetto Clinical Research

Summerville, South Carolina, 29485, United States
Panax Clinical Research

Miami Lakes, Florida, 33014, United States
Pinnacle Clinical Research

Austin, Texas, 78757, United States
Pinnacle Clinical Research San Antonio

San Antonio, Texas, 78229, United States
Pinnacle Research, Georgetown TX

Georgetown, Texas, 78229, United States
Premier Research

Clarksville, Tennessee, 37043, United States
Quality Research, Inc.

San Antonio, Texas, 78209, United States
San Fernando Valley Health Institute

Canoga Park, California, 91302, United States
South Texas Research Institute

Brownsville, Texas, 78539, United States
Sun Research Institute

San Antonio, Texas, 78215, United States
Tampa Bay Medical Research, Inc.

Clearwater, Florida, 33761, United States
Tandem Clinical Research

Marrero, Louisiana, 70072, United States
Tandem Clinical Research GI - New York

New York, New York, 10033, United States
Texas Clinical Research Institute

Arlington, Texas, 76012, United States
The Institute for Liver Health (Arizona Liver Health)

Chandler, Arizona, 85224, United States
Theia Clinical Research LLC

Temple Terrace, Florida, 34211, United States

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