TYPE 2 DIABETES

This study is testing whether meals tailored to specific cultural backgrounds can help people with type 2 diabetes manage their blood sugar better. Researchers are comparing blood sugar levels when 30 Asian Indian and Filipino participants eat their regular diet versus specially …

This study is testing a new drug called CMG190303, which combines two existing medications, to see if it works better than taking those medications separately. It aims to help adults with type 2 diabetes and high cholesterol better control their blood sugar and 'bad' LDL choleste…

This study tests whether teaching digital skills during a hospital stay helps Latino patients with type 2 diabetes manage their care after going home. Researchers will train patients on how to use online patient portals and telehealth services. They'll compare these patients to o…

This study is testing whether a support program can help Chinese immigrants in New York City better manage their Type 2 diabetes. The program combines weekly educational videos with help from a community health worker to address daily challenges. Researchers will compare this app…

This study is testing if a single pill combining two existing drugs works better than either drug alone for people who have both type 2 diabetes and high blood pressure. About 221 participants will take either the combination pill or one of the single drugs for 12 weeks to see wh…

This study is testing a new weekly injection called MET097 to help adults with type 2 diabetes and overweight or obesity lose weight and better control their blood sugar. About 1,000 participants will receive either the real injection or a placebo (a shot with no medicine) for ab…

This study is testing if educational videos sent by text, with or without extra support from a community health worker, can help Chinese immigrants in New York City better manage their Type 2 diabetes. The goal is to see if these approaches improve blood sugar control more than u…

This study aims to see if a new drug called HRS9531 works better than a placebo (inactive substance) at lowering blood sugar in adults with type 2 diabetes. It is for people whose blood sugar is still not well controlled even while taking a long-acting insulin. About 300 particip…

This study is testing if a special high-protein nutritional drink can help people with type 2 diabetes keep their muscle mass while they lose weight. It is for overweight adults who are about to start new injectable diabetes medications like Ozempic or Mounjaro. Researchers want …

This study is testing whether providing free continuous glucose monitors (CGMs) to low-income adults with poorly controlled type 2 diabetes helps improve their blood sugar levels and quality of life. Researchers will give CGMs to 17 participants who can't afford them and track th…

This study is testing whether a fully automated insulin delivery system can improve blood flow and oxygen levels in the kidneys of people with type 2 diabetes and chronic kidney disease. About 76 adults will use either the automated system or their standard insulin therapy for 26…

This small, early-stage study is testing whether a ketone supplement drink can improve heart function in people who have both type 2 diabetes and a specific type of heart failure. Researchers will give 10 participants the supplement and use heart scans and blood tests to see if i…

This study is testing if a weekly injection called mazdutide can slow down or improve memory and thinking problems in people who have both type 2 diabetes and early dementia. Over 76 weeks, 420 participants will receive either the active drug or a placebo (dummy injection) to see…

This study has two main goals. First, it aims to find out how common memory and thinking problems are in older adults with type 2 diabetes. Second, it will test a 2-year personalized health program designed to slow down cognitive decline. The program combines medication managemen…

This study is testing whether a diet that replaces some animal protein (like meat and dairy) with plant protein (like beans and nuts) can help people with type 2 diabetes manage their blood sugar levels better than a standard diabetes diet. About 146 overweight or obese adults wi…

This study is testing two different three-drug combinations to see which is better at controlling high blood sugar and potentially putting newly diagnosed type 2 diabetes into remission. It will involve 240 adults recently diagnosed with diabetes and high blood sugar levels. One …

This study is testing whether a specific, intense form of exercise called High-Intensity Interval Training (HIIT) can improve how the muscles of people with type 2 diabetes process sugar and respond to insulin. Researchers want to see if HIIT helps the body store sugar in muscles…

This pilot study is testing if adding blood flow restriction (using a special cuff) to regular treadmill walking is a practical and potentially more effective way to help manage type 2 diabetes. For 6 weeks, 60 adults with type 2 diabetes will either walk on a treadmill normally …

This study is testing a 'produce prescription' program designed with and for Native American older adults living on the Flathead Reservation in Montana. Healthcare providers will give eligible participants vouchers to buy fresh fruits and vegetables at a local food center, aiming…

This study aims to find the best aspirin regimen for people with type 2 diabetes who don't respond well to standard low-dose aspirin. Researchers will test different doses and formulations (enteric-coated vs. chewable) in 30 participants to see which one most effectively prevents…

This study is testing a once-daily pill called orforglipron to see if it helps people with obesity or overweight and type 2 diabetes lose weight and better control their blood sugar. It will compare the pill's effects to a placebo (a dummy pill) in about 600 participants over 18 …

This study is testing a new digital tool that uses artificial intelligence to help people with Type 2 diabetes manage their condition. The tool sends text messages to patients and provides reports to their doctors, aiming to improve communication and help lower long-term blood su…

This study investigates how weight loss can potentially reverse type 2 diabetes by reducing fat buildup in the pancreas. Researchers will follow 104 overweight participants with different diabetes stages as they complete an 8-12 week low-calorie diet program. The goal is to under…

This study is testing if a program that provides healthy food vouchers works better when paired with a continuous glucose monitor (CGM) and nutrition counseling. It will involve 60 adults with type 2 diabetes who also struggle to afford or access healthy food. The goal is to see …

This small pilot study is testing a new approach to managing type 2 diabetes. It aims to see if using a continuous glucose monitor (CGM) to track blood sugar can help dietitians create a personalized 12-week diet plan for each participant. The goal is to see if this method is pra…

This study is testing whether a special online education program helps young people (ages 8-21) with type 2 diabetes better manage their blood sugar. Participants will either get the new 4-week online program with virtual coaching or standard care. The main goal is to see if the …

This study is testing whether adding smartphone apps to standard diabetes care helps people better manage their condition. About 200 adults with type 2 diabetes who are at higher risk for complications will participate. One group will use apps focused on small healthy habits and …

This is an early-stage study to test the safety and how the body processes a new drug called TLC 6740. It will first be given to healthy volunteers to check for side effects. Later, it will be tested in people with obesity, some of whom also have type 2 diabetes, to see if it mig…

This study is observing how well a diabetes medication called Proline Plus Empagliflozin works in real-world settings for people with type 2 diabetes. Researchers will follow 3,000 patients for up to 48 weeks to see how effectively it controls blood sugar and monitor for any side…

This study is testing a new weekly injection called LY3457263 to see if it can help lower blood sugar in people with type 2 diabetes. It is for people whose blood sugar is still too high even though they are already taking stable doses of the medications semaglutide or tirzepatid…

This study is testing whether a ketone ester supplement can improve heart function and exercise capacity in people with type 2 diabetes. Researchers will compare the supplement to a placebo in 30 participants using heart scans and exercise tests. The goal is to see if this nutrit…

This study is testing a community program designed to help Native Hawaiians manage common health conditions like type 2 diabetes, high blood pressure, and high cholesterol. The program combines education on traditional diets and lifestyles with cooking demonstrations. Researchers…

This study is testing if a simple 12-week program using a Fitbit activity tracker and personalized text messages can help people with type 2 diabetes. Researchers want to see if this tech-based approach is easy to use and acceptable for 36 sedentary adults. The main goal is to ch…

This study follows 470 adults in Hungary with type 2 diabetes who are starting a pill called oral semaglutide as part of their regular doctor's care. Researchers will track changes in blood sugar control and body weight over about 6 months to see how well the treatment works in e…

This study is testing whether a new pill called HDM1002 can help control blood sugar in adults with type 2 diabetes who haven't yet started medication. It will involve 360 participants who will take either the new pill or a placebo (inactive pill) for one year. The main goal is t…

This small pilot study is testing whether a higher dose of the common diabetes drug metformin works better for young people aged 10-21. Researchers think young bodies process the drug faster, so the standard adult dose might not be strong enough. The study will compare the standa…

This early-stage study is testing a new oral medication called ZE63-0302 in people with type 2 diabetes. Researchers want to understand how safe the drug is, how the body processes it, and how it affects blood sugar levels. The study will involve 60 adults who will take either th…

This study is testing if a treatment called Physiologic Insulin Resensitization (PIR) can help people with both advanced kidney disease and type 2 diabetes. It will compare PIR to standard care in 120 participants to see if it better protects kidney function and improves diabetes…

This study is testing whether a special breathing training program can improve blood flow to the brain and thinking skills in older adults with type 2 diabetes. Researchers will compare 80 participants, half with diabetes and half without, to see if repeated, brief sessions of lo…

This study is testing whether switching one medication in a three-drug combination works better for controlling type 2 diabetes. Researchers are comparing two different medication combinations in adults with type 2 diabetes to see which one manages blood sugar more effectively ov…

This study is testing whether time-restricted eating—limiting all food intake to a specific daily window—can help people with type 2 diabetes better manage their condition. It will compare this eating pattern to standard lifestyle advice in 112 overweight adults. The main goal is…

This study is testing whether a low-carbohydrate diet can help teenagers with type 2 diabetes better control their blood sugar and improve their body's response to insulin. Over 24 weeks, 40 participants aged 12-18 will follow either a low-carb diet or the standard diabetes diet …

This study is testing whether combining healthy food support and fitness guidance with new diabetes medications helps women stick with their treatment and improves heart health. Researchers will follow 200 post-menopausal women with type 2 diabetes and heart health risks for 24 w…

This study is testing if restricting meals to an 8-hour window, either early or late in the day, can improve blood sugar control and heart health in people who are overweight and have prediabetes or type 2 diabetes. It will involve 30 participants who will try both eating schedul…

This study is testing if group doctor appointments are a helpful way to care for teenagers with type 2 diabetes. Researchers will compare the group visit model to regular one-on-one appointments for 160 teens. The main goals are to see if teens like the group visits and if they i…

This study is testing if the diabetes medication semaglutide (Ozempic) works well for people who have both type 2 diabetes and a spinal cord injury. About 50 participants will receive either the real drug or a placebo injection weekly for 24 weeks. Researchers will measure change…

This study is designing and testing a new 'team clinic' approach where teens with type 2 diabetes attend group appointments instead of individual visits. Researchers will create activities focused on nutrition, exercise, stress management, and peer support to see if this approach…

This study aims to see if a new version of the diabetes pill oral semaglutide works as well and is as safe as the currently approved version. It involves about 264 Japanese adults with type 2 diabetes who will take one of the two pill versions for about 27 weeks. The main goal is…

This study is testing whether a 12-month lifestyle program can help people with type 2 diabetes achieve remission, meaning they no longer need medication. It will enroll 24 participants to try a program starting with a very low-calorie diet, followed by either a low-carb or high-…

This early Yale University study is exploring whether applying focused ultrasound waves to the abdomen can help lower high blood sugar levels in people with type 2 diabetes. It will involve 30 participants who are already on stable diabetes medication. The main goal is to check i…

This is an early-stage study to check the safety and how the body processes a new drug called LY4086940. It will involve about 201 healthy people and people who are overweight, have obesity, or have type 2 diabetes. The main goal is to see if the drug is safe and well-tolerated a…

This study is testing whether a new injectable medicine called HDM1005 is better than a placebo (a dummy treatment) at lowering blood sugar in people with type 2 diabetes. It will involve 240 adults whose diabetes is not well controlled by diet and exercise alone. The main goal i…

This early-stage study is testing the safety and body's response to a new injectable medicine called NNC9733-0001 for type 2 diabetes. It involves 72 participants, including both healthy volunteers and people with type 2 diabetes, who receive either the medicine or a placebo inje…

This study is testing if a free smartphone app can help people with type 2 diabetes make healthier food choices. The app scans barcodes on groceries to give simple nutrition ratings. Researchers will see if using the app for 6 months, along with standard advice, improves blood su…

This study is testing whether giving families free vouchers for fresh fruits and vegetables can help children with type 2 diabetes. Researchers will provide vouchers to 200 families in California and track if this improves the children's diet, blood sugar levels, and reduces hous…

This study is testing a new medical device that uses magnets to create a connection in the digestive system. The goal is to help adults with obesity lose weight and improve type 2 diabetes by partially rerouting food. Researchers will check if the magnets can be placed correctly,…

This study is testing if higher doses of the diabetes medication dulaglutide are safe and effective for teenagers aged 10-17 with type 2 diabetes. It will involve about 55 teens and last around 8 months. Researchers will check if the medicine helps control blood sugar and body we…

This study is testing whether having a doctor visit patients at home helps manage high blood pressure and type 2 diabetes better than standard clinic visits. Researchers will compare health outcomes for 100 adults who receive two home visits versus those who get usual clinic care…

This study is testing if a daily eating schedule can help people manage type 2 diabetes. About 100 participants with type 2 diabetes will try eating all their food within a 10-hour window each day for one year. Researchers will check if this approach improves blood sugar control,…

This study is testing a 24-week community program called Black Impact, designed to improve heart health and reduce stress in Black men. Participants will receive weekly physical activity, health education, and support from coaches. The goal is to see if this program can be a scal…

This large, late-stage study is testing a once-daily pill called orforglipron to see if it helps people lose weight and is safe. It will enroll about 1,200 adults who have obesity or are overweight, some of whom also have type 2 diabetes. The main goal is to see how well the pill…

This study is testing whether a device called the iLet Bionic Pancreas can help adults with type 1 or type 2 diabetes better manage their blood sugar when it is prescribed and monitored by their regular primary care doctor. Researchers will compare 13 weeks of using the automated…

This study is testing whether drinking whey protein before meals can help control daily blood sugar levels in older adults (ages 75-90) with type 2 diabetes. Participants will try two different doses of whey protein and a placebo drink for one week each, in a random order, while …

This study is testing whether a mobile app can help people who have recently had a stroke and also have prediabetes or type 2 diabetes eat a healthier diet. The goal is to see if using the app to follow a Mediterranean-style diet can lower the risk of having another stroke and im…

This study is testing a new oral drug called clofutriben for adults with type 2 diabetes that remains high despite taking multiple medications. The goal is to see if lowering a specific stress hormone (cortisol) in the body can help control blood sugar. About 1,500 participants w…

This study is testing whether community cooking classes focused on traditional Native Hawaiian foods can help people better manage diabetes, high blood pressure, and weight. The program involves 1,780 Native Hawaiian adults who will attend quarterly cooking demonstrations and cul…

This study is testing a new magnetic device system (MagDI) designed to create a new connection in the small intestine. The goal is to see if this rerouting procedure is safe and can help with weight management and improve blood sugar control in adults with obesity, with or withou…

This study is testing whether a special camera with artificial intelligence (AI) software can help more young people with diabetes get screened for eye damage. Researchers want to see if using this quick, in-office camera increases screening rates, especially for underserved yout…

This study aims to see if simple strategies can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains when shopping for groceries online. Researchers will test two approaches: using marketing nudges (like highlighting whole grain …

This study is testing a special online program designed to help college students at risk for type 2 diabetes. It aims to see if a tailored, digital version of a proven diabetes prevention program can help students lose weight and improve their health. The program focuses on reach…

This study tests a family-focused health program designed to prevent type 2 diabetes in Black communities in Southwest Georgia. It adapts a proven diabetes prevention curriculum for both parents and children, focusing on healthy eating and increased physical activity. Researchers…

This study is testing a virtual program designed to prevent eating disorders in young women with type 2 diabetes. The program aims to improve body image, reduce disordered eating behaviors, and help with diabetes management. Researchers are working with 42 women aged 18-40 who ha…

This study explores a surprising link: having low 'bad' cholesterol (LDL) might actually increase the risk for type 2 diabetes. Researchers believe this happens when LDL enters fat tissue too easily. They are testing if a 6-month supplement of fish oil (omega-3 fatty acids) can t…

This study is testing a new system to prevent heart failure in people with type 2 diabetes. It uses a simple blood test and a risk score to identify patients at high risk. When a high risk is found, the system alerts the patient's doctor to start proven preventive medications ear…

This study is testing if a special light therapy, used during dental cleaning, works better than standard cleaning alone to reduce bad breath in people who have both type 2 diabetes and serious gum disease. Researchers will compare the two treatments over six months to see which …

This study is testing whether adding a self-massage technique with a foam roller to a standard exercise program can improve foot function, balance, and walking ability in people with type 2 diabetes. Forty participants will be randomly assigned to do either exercises alone or exe…

This is a long-term observational study aiming to understand why young people with type 2 diabetes are at higher risk for heart and blood vessel disease. It will follow 930 participants aged 12-25 for up to 25 years, comparing those with diabetes, those who are overweight, and he…

This large observational study aims to collect real-world information on how patients with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease are currently managed. It will enroll 35,000 adults from many countries to track their treatments, doctor …

This study aims to understand the relationship between nutritional knowledge and how well people with type 2 diabetes follow the Mediterranean diet. Researchers will survey 500 diabetes patients about their diet knowledge and eating habits, while also measuring their blood sugar,…

This study aims to understand how poor blood flow in small vessels might contribute to heart and muscle problems in people with type 2 diabetes. Researchers want to see if a 15-week exercise program can improve how the body uses insulin and increase blood flow to the heart and mu…

This is the first study testing a new drug called PATAS in humans. Researchers want to see if single injections are safe and how the drug moves through the body. The study involves 56 healthy volunteers who will receive either the drug or a placebo. The goal is to gather initial …

This study aims to understand how blood sugar levels after a liver transplant affect a patient's recovery and the long-term success of the transplant. Researchers will have 40 recent liver transplant patients wear a small, hidden glucose monitor for 30 days after leaving the hosp…

This early-stage study aims to understand how eating food affects how the body absorbs an experimental medication called CX11, which is being developed for obesity and type 2 diabetes. Researchers will test 32 healthy volunteers to see if taking the pill with or without food chan…

This study aims to understand how weight loss surgery changes the bacteria in your gut and how those changes might improve heart health and diabetes. Researchers will follow 300 patients for up to 10 years after their surgery, collecting blood and stool samples to look for patter…

This study aims to understand how the diabetes drug pioglitazone affects energy production inside liver cells in people with Type 2 diabetes and fatty liver disease (NAFLD or NASH). Researchers will measure chemical processes in the liver before and after 16 weeks of treatment. T…

This study aims to understand how the body processes a nutrient called arginine in teenagers with type 2 diabetes. Researchers will test if giving extra arginine can help the pancreas produce more insulin. The goal is to gather knowledge that could lead to new, low-cost ways to m…

This study aims to understand how a 12-week exercise program changes how the bodies of older adults with type 2 diabetes process and use protein from food. Researchers will compare 15 older adults with diabetes to 15 without, measuring protein efficiency, fitness, and gut bacteri…

This study aims to understand how a common diabetes drug (liraglutide) and blood sugar control affect a specific hormone (GLP-1) produced inside the pancreas. Researchers will compare these effects in 60 people with Type 1 and Type 2 diabetes who use insulin. The goal is to learn…

This study aims to understand how tiny particles in the blood, called extracellular vesicles, affect blood vessel function in people with type 2 diabetes. Researchers will study 60 adults with and without diabetes to see if these particles harm blood vessels and if regular exerci…

This study aims to discover blood markers that could help predict whether a person's type 2 diabetes will go into remission after weight loss surgery. Researchers will collect blood, muscle, and fat tissue samples from 50 obese patients with type 2 diabetes who are scheduled for …

This study aims to understand how heart disease develops over time in people with type 2 diabetes. Researchers will follow 1,000 participants who have already had a detailed heart scan, repeating the scan to measure changes in plaque buildup in their arteries. By tracking these c…

This study aims to understand how a natural cellular cleanup process, called autophagy, affects the function of tiny blood vessels in people with Type 2 Diabetes. Researchers will compare 60 adults, some with diabetes and some healthy, by testing their blood vessel function befor…

This study uses a special full-body PET scanner to see how two natural gut hormones (GIP and GLP-1) affect how the body uses sugar and how blood flows to different organs. It involves healthy volunteers and people with type 2 diabetes. The goal is to gather detailed information t…

This study aims to understand why people with prediabetes and type 2 diabetes tire more quickly during exercise. Researchers will test a special 8-week leg exercise program that temporarily restricts blood flow to see if it improves muscle fatigue and blood vessel function. The g…

This early-stage study aims to understand how two common type 2 diabetes medications, empagliflozin and pioglitazone, interact in the body. Researchers will measure how they affect the body's production of sugar, fat breakdown, and ketones in 64 participants. The goal is to gathe…

This study aims to understand how eating a lot of fructose (a common sugar) changes the bacteria in your gut and affects your metabolic health, including liver fat and diabetes risk. Researchers will have 30 adults who poorly absorb fructose follow two different 12-day diets—one …

This study aims to discover early warning signs that could predict future heart failure in people with type 2 diabetes. Researchers will follow 500 adults over 50 with diabetes but no known heart disease, performing yearly heart scans, blood tests, and walking tests. The goal is …

This study aims to gather detailed information about the health, diet, and fitness of active-duty U.S. Army soldiers. Researchers will collect data from 600 soldiers through surveys, physical measurements, and lab tests on blood and stool samples. The goal is to create a clear pi…

This is an early-stage study to understand how a new injection called SHR-3167 behaves in the body of people with type 2 diabetes. It will measure the drug's levels in the blood over time and check for side effects, including low blood sugar. The goal is to gather basic safety an…

This study aims to understand if taking the common diabetes drug metformin before hospital admission affects survival rates for patients in intensive care with a severe condition called lactic acidosis. Researchers will look back at the medical records of 100 adults with type 2 d…

This study is collecting information from 3000 Italian adults with type 2 diabetes to understand their risk for heart disease and see how well their current treatments follow medical guidelines. Researchers will observe patients during regular doctor visits without changing their…