TYPE 2 DIABETES

This study tests a new supplement called HP-211, made from herbs and vegetables, to see if it helps people with type 2 diabetes control their blood sugar better. About 300 adults with type 2 diabetes will take 0 to 3 tablets twice daily for 90 days. The main goal is to measure ch…

This study tests a lifestyle program for adults recently diagnosed with type 2 diabetes. Participants use continuous glucose monitors to track blood sugar after meals and follow a personalized plan to minimize spikes. The goal is to see if this approach lowers blood sugar as well…

This study tests whether specially trained community pharmacists can safely prescribe kidney-protective medications to people with type 2 diabetes and early kidney disease who don't have a family doctor. About 120 adults from Nova Scotia will be randomly assigned to either pharma…

This study provides families on Medi-Cal who have a child with type 2 diabetes with a prescription for free fresh fruits and vegetables. The goal is to help families eat healthier, reduce food insecurity, and improve the child's blood sugar and overall health. About 200 children …

This study tests whether a combination of three drugs (THP-00101, THP-00102, and THP-00103) works better than taking just one or two of them for people with both type 2 diabetes and high blood pressure. About 221 adults will take the pills daily for 12 weeks. The goal is to see i…

This study tests whether a 24-week food and fitness program helps 200 post-menopausal women with type 2 diabetes and heart-kidney problems stick to their new GLP-1 medication. The program includes exercise sessions, nutrition counseling, and home food deliveries. Researchers will…

This study tests if a mobile app called FoodSwitch can help 900 Swedish adults with type 2 diabetes make better food choices. The app lets you scan barcodes to see easy-to-understand nutrition labels. Half of the participants will use the app plus get standard advice, while the o…

This study tests a new magnetic system (MagDI) that creates a shortcut in the small intestine to help with weight loss and type 2 diabetes. It involves 60 adults with obesity (BMI 30-50) who have diabetes or regained weight after previous weight-loss surgery. The goal is to see i…

This early-stage study tests a new medicine (NNC9733-0001) to see if it is safe and can lower high blood sugar in people with type 2 diabetes. About 72 participants — both healthy volunteers and people with diabetes — will receive either the study drug or a placebo as a single in…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device or continue their routine care for 13 weeks to see if it improves blood sugar co…

This early-stage study tests a new injection called SHR-3167 in 55 adults with type 2 diabetes. The goal is to see how the drug moves through the body and how well it controls blood sugar. Participants will be monitored for side effects and low blood sugar events.

This study tests if HRS9531 can lower blood sugar better than a placebo in people with type 2 diabetes who are already using basal insulin. About 300 adults will receive either HRS9531 or a placebo for 40 weeks. The main goal is to see if HRS9531 improves long-term blood sugar le…

This study tests whether a 12-month program of diet and exercise can help people with type 2 diabetes achieve remission. It includes 24 adults who are overweight and not on insulin. The goal is to see if this approach is practical and safe before a larger trial.

This study tests whether changing from one diabetes medication combination to another can better control blood sugar in adults with type 2 diabetes. About 204 participants will be randomly assigned to either stay on their current drugs or switch to a new combination. The main goa…

This study tests if a mobile app called PortionSize Ed can help 40 adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean diet. Participants will either use the full app with dietitian support or a basic version. The goal is to see if the …

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will enroll 100 adults aged 18-60 who speak English or Spanish and have poorly controlled blood pressure or diabetes. The goal is to see if home visits lead…

This study tests a method called physiologic insulin resensitization (PIR) to see if it can improve kidney function in people with advanced chronic kidney disease and type 2 diabetes. About 120 adults will either receive PIR or standard care. Researchers will measure kidney healt…

This pilot study enrolls 40 adults with type 2 diabetes to see if a pharmacist-led program using a continuous glucose monitor (CGM) improves blood sugar levels and healthy behaviors compared to standard finger-stick testing. Participants will use a CGM for 12 weeks and have their…

This study compares two diabetes medications, enavogliflozin and pioglitazone, when added to metformin (with or without another drug) in 120 adults with type 2 diabetes. The goal is to see which drug better controls blood sugar and improves other health measures like weight, body…

This study tests whether repeated shivering from cold exposure can improve how the body uses insulin in people with type 2 diabetes. Fifteen adults aged 40-75 will undergo 10 days of cold exposure to trigger shivering. Researchers will measure changes in insulin sensitivity and f…

This study tests a new tablet called HDM1002 in 360 adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants will receive either the study drug or a placebo for 40 weeks to see if it safely lowers blood sugar levels. The goal i…

This study tests whether adding couples counseling to a step-counting program helps people with type 2 diabetes walk more and improve blood sugar. About 200 couples will join. Half will get step counters and step goals from their doctor, plus counseling sessions to improve commun…

This pilot study tests whether personalized nutrition advice, guided by continuous glucose monitoring (CGM), is feasible and helpful for adults with type 2 diabetes. Twenty participants will receive a 12-week dietary intervention and use a CGM to track blood sugar. The goal is to…

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The main goals are to check safety, how the drug moves through the body, and early signs of effectiveness. Up to 564 participants will take sing…

This study tests whether meals designed for specific ethnic groups (Asian Indian or Filipino) can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for one month while eating their usual diet and then the tailor…

This study tests a smartphone-based tool called iMatter2 that uses artificial intelligence to help people with type 2 diabetes track their symptoms and communicate with their doctors. About 353 adults with uncontrolled diabetes will use the tool or receive usual care for 12 month…

This study compares two ways for adults with type 2 diabetes to track blood sugar: a continuous glucose monitor (CGM) worn on the body versus traditional finger-prick tests. Researchers want to see if using CGM for short periods leads to better blood sugar levels and improved wel…

This study looks at whether eating only during certain hours (early or late in the day) can help control blood sugar and improve heart health in people who are overweight and have normal blood sugar, prediabetes, or type 2 diabetes. Researchers will track 30 participants' glucose…

This study compares two triple-drug combinations to see which works better for controlling blood sugar and possibly achieving diabetes remission in people newly diagnosed with type 2 diabetes. The trial will include 240 adults aged 18 to 65 with high blood sugar levels. Participa…

This study tests whether personalized marketing and discounts in an online grocery store can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains. About 216 adults aged 45-70 from Pennsylvania who already shop online for grocerie…

This study tests a new drug called HM11260C for adults with type 2 diabetes whose blood sugar is still too high despite taking metformin and dapagliflozin. About 118 participants will receive either the new drug or a placebo for 36 weeks to see if it safely lowers HbA1c levels. T…

This study tests an experimental drug called HDM1005 in 240 adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants will receive either HDM1005 or a placebo for 36 weeks, then everyone gets the drug for another 16 weeks. The m…

This early study is testing if using focused ultrasound on the abdomen can help people with type 2 diabetes control their blood sugar. About 30 adults with stable diabetes will receive the treatment to see if it is safe and affects glucose levels. The goal is to explore a new, no…

This study tests a new medicine called clofutriben for people with type 2 diabetes that is hard to manage, especially if they may have high cortisol levels. About 1500 adults will first be screened for cortisol issues, then receive either clofutriben or a placebo daily for 24 wee…

This study tests whether adding a continuous glucose monitor (CGM) and nutrition counseling to a food-as-medicine program helps adults with type 2 diabetes and food insecurity better manage their blood sugar. Sixty participants will be split into two groups: one gets the standard…

This study compares a low-carbohydrate diet to a standard diet in 40 adolescents aged 12-18 with type 2 diabetes over 24 weeks. The goal is to see if the low-carb approach improves blood sugar control and insulin sensitivity. Participants must have stable diabetes and not be on i…

This study tests whether a digital lifestyle app, combined with standard care, helps adults with type 2 diabetes who are at high risk for complications. About 200 participants in Finland will use the app for 12 months to support healthy eating, activity, and weight loss. Research…

This 12-month study tests whether a nurse-led smartphone app can help people with type 2 diabetes who use insulin and are on Medicaid better manage their blood sugar. The app provides education, phone support, and tracking tools. The study will enroll 60 adults who own a smartpho…

This study tests whether limiting all eating to a 10-hour window each day for one year can help people with type 2 diabetes improve their blood sugar control. About 102 adults with type 2 diabetes will follow this time-restricted eating plan. Researchers will track changes in HbA…

This study looks at how well oral semaglutide works for managing blood sugar and weight in adults with type 2 diabetes. About 470 participants will take the pill as prescribed by their doctor and be followed for about 6 months. Researchers will measure changes in blood sugar leve…

This study tests whether shared medical appointments—where teens with type 2 diabetes attend clinic visits and group activities together—are a good way to deliver care. Researchers will compare this approach to standard care in 160 teens aged 12-18. The goal is to see if group vi…

This study is testing a program called PILI 'Āina for Native Hawaiians with type 2 diabetes, high blood pressure, high cholesterol, or overweight. The program promotes traditional Hawaiian diets and cooking to improve health and social connections. About 210 adults will take part…

This study compares two medications, clopidogrel and cilostazol, to see which better slows the thickening of neck arteries in people with type 2 diabetes. About 120 adults with diabetes and early signs of artery disease will take one of the drugs for a period. The goal is to find…

This study tests a new drug called icovamenib in 60 adults with type 2 diabetes whose blood sugar is not well controlled despite taking other diabetes medications. Participants will take either icovamenib or a placebo daily for 12 weeks to see if it improves blood sugar levels. T…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, and weight by returning to traditional diets and cooking methods. About 1,780 adults who are overweight and have these conditions will take part. The goal is to i…

This study looks at whether drinking whey protein before meals can help older adults (ages 75-90) with type 2 diabetes keep their blood sugar levels steadier throughout the day. Over two 7-day periods, participants will take either a whey protein drink or a placebo before each me…

This study tests whether higher doses (3.0 mg and 4.5 mg) of the diabetes drug dulaglutide are safe and work well in teenagers aged 10 to 17 with type 2 diabetes. About 55 participants will take the drug for around 8 months while doctors monitor side effects, blood sugar levels, …

This study tests whether short, controlled sessions of low oxygen (intermittent hypoxia) can improve blood flow to the brain and thinking skills in adults aged 60-85 with type 2 diabetes. Researchers will compare the effects of this training against a placebo in 80 participants. …

This study tests a new weekly injection (mazdutide) in 420 people with type 2 diabetes who also have mild cognitive impairment or early dementia. The goal is to see if the drug can slow down memory and thinking problems over 76 weeks. Participants are randomly assigned to receive…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will do weekly physical activity and health education, and work with a coach and community health worker. The goal is to see if the program improves heart health and r…

This study tests a new medicine called MET097, given as a weekly shot under the skin, to help adults with overweight or obesity and type 2 diabetes lose weight. About 1,000 people will take part for 21 months, with some receiving the study drug and others a placebo. The goal is t…

This study is testing a new device that uses magnets to create a shortcut in the digestive system, helping people with obesity and type 2 diabetes lose weight and control blood sugar. About 35 adults aged 18-65 with a BMI between 30 and 50 will receive the procedure. The goal is …

This early-stage study tests a new medicine called HMS1005 in 40 adults with type 2 diabetes. The main goals are to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo, and researchers will also monitor blood sugar levels.…

This study tests whether time-restricted eating (eating only during a set window each day) can help preserve insulin-producing cells and improve blood sugar control in people with type 2 diabetes who are overweight. About 112 adults will be randomly assigned to follow this eating…

This study looks at whether a type of diabetes medicine called GLP-1RA (like semaglutide) can improve nerve damage in the heart caused by type 2 diabetes. About 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers will che…

This study tests whether weekly diabetes education videos sent by text, plus help from a community health worker, can improve blood sugar control in Chinese immigrants with type 2 diabetes. 270 participants will be randomly assigned to get the video program right away or to wait …

This study tests two ways to help Chinese immigrants with type 2 diabetes control their blood sugar: watching educational videos alone, or videos plus support from a community health worker. About 540 adults in New York City will take part. The goal is to see which approach works…

This study looks at whether high-intensity interval training (HIIT) can improve how muscles use sugar in people with type 2 diabetes. The goal is to see if HIIT helps muscles store sugar better and reduces fat in the liver. About 36 adults with type 2 diabetes will participate in…

This study tests a new drug called CMG190303 in 240 adults with type 2 diabetes and high cholesterol. It compares the drug's effects on blood sugar and LDL cholesterol against standard treatments. The goal is to see if the new drug works better and is safe.

This study tests a program that gives fresh fruits and vegetables to Native American adults aged 55 and older who face food insecurity and are at risk for type 2 diabetes. Participants receive vouchers to buy healthy food at local centers, along with nutrition education. The goal…

This study is observing how well a combination diabetes pill (Proline Plus Empagliflozin) works in everyday medical practice. Researchers will track blood sugar control in 3,000 adults with type 2 diabetes over 24 weeks. The study does not change how doctors treat patients—it sim…

This study tests whether semaglutide, a common diabetes drug, works well for people with spinal cord injury (SCI) who also have type 2 diabetes. SCI increases the risk of diabetes, but standard treatments may not work the same. The study will measure how the drug affects blood su…

This study tests a new daily pill, icovamenib, for people with type 2 diabetes whose blood sugar is still too high despite taking Ozempic. About 60 adults will receive either the drug or a placebo for 12 weeks to see if it safely improves blood sugar control. The goal is to offer…

This study is testing whether a higher-than-normal dose of metformin (1350 mg twice a day) is acceptable and feasible for young people aged 10-21 with type 2 diabetes. Researchers will compare this higher dose to the standard dose (1000 mg twice a day) and monitor blood sugar con…

This study looks at whether a special high-protein drink can help overweight or obese adults with type 2 diabetes preserve muscle mass while they start taking popular weight-loss drugs like Ozempic or Mounjaro. About 60 participants will be randomly assigned to receive the drink …

This study tests a new weekly injection, LY3457263, in adults with type 2 diabetes whose blood sugar is still too high despite taking stable doses of semaglutide or tirzepatide. About 240 participants will receive either the new drug or a placebo for roughly 9 months. The main go…

This study tests whether a structured lifestyle program can help Malaysian adults with type 2 diabetes achieve remission—meaning blood sugar returns to normal without needing diabetes medication. 92 participants will be randomly assigned to either the lifestyle program or usual c…

This study tests whether a tailored exercise program, combined with health screenings, can reduce falls, fractures, and heart problems in people aged 65+ with type 1 or type 2 diabetes. 490 participants will be assigned to either the exercise program or usual care and followed fo…

This study gives free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers want to see if easier access to real-time blood sugar data helps lower A1c levels and improves quality of life. Participants wear the sensor for 14-day period…

This study tests whether a 4-week education program about continuous glucose monitors (CGMs) helps youth aged 8-21 with type 2 diabetes improve their blood sugar control compared to standard care. Participants will attend virtual sessions, use an online workbook, and wear a CGM f…

This study tests whether a fully automated insulin delivery system (closed-loop) can improve kidney oxygen levels in adults with type 2 diabetes and moderate chronic kidney disease. About 76 participants will use either the automated system or standard insulin therapy for 26 week…

This study tests whether partially replacing animal protein with plant protein in the diet can improve blood sugar control in people with type 2 diabetes who are overweight or obese. Over 24 weeks, 146 adults will follow either a plant-based diet or a standard healthy diet. The m…

This study looks at whether a finger-prick blood test done at home can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard test requires a vein drip and multiple blood draws over hours, which…

This study tests whether a special camera with artificial intelligence can help more young people with diabetes get screened for diabetic retinopathy, an eye disease that can lead to blindness. The study will include 500 underserved youth with type 1, type 2, or cystic fibrosis-r…

This study tests a tailored online program to help 80 UCLA undergraduates at risk for type 2 diabetes lose weight and improve health. Participants will take short weekly lessons over 9 months, with some receiving the full program and others getting general wellness materials. The…

This study is testing a new online program called Diabetes Body Project 2, designed to prevent eating disorders in women aged 18-40 with type 2 diabetes. The program focuses on improving body image and reducing unhealthy eating behaviors. Researchers want to see if it helps with …

This study tests a heart failure screening and prevention strategy for people with type 2 diabetes. Researchers will use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then help doctors prescribe proven preventive medications. The goal is to see if this…

This study looks at how common thinking problems are in people aged 65+ with type 2 diabetes. It then tests a program that combines healthy habits, exercise, and mental activities to see if it can prevent or slow down memory and thinking decline. About 420 participants will be fo…

This study tests a family-oriented program to help Black families in Southwest Georgia lower their risk of type 2 diabetes. Parents with prediabetes and their children aged 8-15 will take part in healthy lifestyle activities over 20 months. The goal is to see if parents can lose …

This study tests whether adding antimicrobial photodynamic therapy (aPDT) to standard gum cleaning and tongue scraping can better reduce bad breath in people with type 2 diabetes and advanced gum disease. About 32 adults will receive either standard care or standard care plus aPD…

This study tests whether adding a simple self-massage technique (myofascial release) to a standard exercise program can improve foot function, balance, and walking in people with type 2 diabetes. About 40 adults aged 30 to 65 with controlled diabetes will be split into two groups…

This study tests whether a ketone ester supplement can improve exercise ability and heart function in people with type 2 diabetes. About 30 adults will take either the supplement or a placebo and undergo heart MRI scans and quality-of-life surveys. The goal is to see if this simp…

This study tests whether walking on a treadmill while wearing bands that slightly restrict blood flow is safe and helpful for people with type 2 diabetes. Sixty adults with diabetes will walk for 96 minutes a week for 6 weeks, either with or without the bands. Researchers will ch…

This early-stage study tests a new medicine called LY4086940 in healthy people and those who are overweight or have obesity, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in differ…

This study tests a virtual health coaching program for adults with type 2 diabetes and mental health challenges. Participants receive weekly coaching calls, support from a care team, and online tools. The goal is to see if this approach improves quality of life compared to usual …

This study looks at how tiny particles released by cells, called extracellular vesicles, affect blood flow in people with type 2 diabetes. Researchers want to understand if exercise can change these particles to improve blood vessel health. The study involves 60 adults aged 30-80…

This study looks at how a person's genes influence their body's response to oral semaglutide, a medication used for type 2 diabetes. About 125 adults with normal to pre-diabetes blood sugar levels will take the drug for two weeks and have their blood tested after a standardized b…

This study looks at whether taking metformin before being admitted to the intensive care unit (ICU) affects survival in people with type 2 diabetes who develop severe lactic acidosis. Researchers will review records of 100 adults admitted to a French hospital ICU between 2014 and…

This study looks at how a 12-week exercise program changes the way older adults (65+) with type 2 diabetes use protein from food. Researchers will measure body composition, fitness, and protein efficiency using special tests. The goal is to understand if exercise can improve musc…

This study looks at how insulin resistance in type 2 diabetes reduces blood flow to muscles and the heart, leading to poor exercise ability. Researchers will test if 15 weeks of exercise training can improve insulin sensitivity and heart function. The study involves 150 sedentary…

This early-stage study looks at whether the drug pioglitazone can block the rise in ketones and sugar production caused by another diabetes drug, empagliflozin. Researchers will measure these effects in 64 adults with type 2 diabetes. The goal is to better understand how these me…

This study looks at why having low 'bad' cholesterol might actually increase the risk of type 2 diabetes. Researchers think it may be due to how cholesterol enters fat tissue. They will test if taking omega-3 (fish oil) for 6 months can reduce this risk in 48 adults aged 45-74 wi…

This study looks at how the body processes arginine, a natural nutrient, in teenagers and young adults with type 2 diabetes. Researchers will compare 30 youth with diabetes to healthy controls using safe, minimally invasive tests. The goal is to understand the disease better and …

This study looks at how well people with type 2 diabetes can produce insulin after drinking a meal replacement shake. Researchers will take blood samples over two hours to measure insulin and blood sugar levels. The goal is to understand differences in insulin production and how …

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This early-stage study is testing a new drug called PATAS in healthy volunteers to see if it is safe and how the body processes it. The goal is to gather initial safety data before testing it in people with Type 2 diabetes. About 56 healthy adults aged 18 to 55 will receive eithe…

This study looks at how sleep duration relates to blood sugar control in 90 adolescents (ages 12-20) with type 2 diabetes. Researchers will measure sleep with a wrist monitor for 14 days and check blood sugar levels. They will also test if offering rewards for meeting sleep goals…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will put 104 overweight adults (with and without diabetes) on a very low-calorie diet for 8-12 weeks, then support weight loss for up to a year. …

This study follows 300 people having metabolic (weight-loss) surgery to see how their gut bacteria change over time and how those changes relate to improvements in heart health, diabetes, and cholesterol. Participants provide stool, blood, and tissue samples before and up to 3 ye…

This study is not testing a new drug or treatment. Instead, it will observe 3000 adults with type 2 diabetes in Italy to see how well their heart-related risks are managed according to current guidelines. Researchers will collect data from routine clinic visits to understand what…

This early-stage study looks at how taking CX11 tablets with or without food changes the drug's levels in the body. It involves 32 healthy adults and is not meant to treat any condition. The results will help design future studies for obesity and type 2 diabetes.

This study looks at how natural gut hormones (GIP and GLP-1) change the way the body uses sugar and moves blood through organs. Healthy volunteers and people with type 2 diabetes will get special PET scans after receiving these hormones or a placebo. The goal is to better underst…

This study is looking for early warning signs of heart failure in 500 people with type 2 diabetes who are over 50. Participants will have blood tests and heart scans to see if certain markers can predict heart problems. The goal is to find better ways to catch heart failure early…

This study looks at how liver cells produce energy in people who have both type 2 diabetes and nonalcoholic fatty liver disease. Researchers will measure liver metabolism before and after 16 weeks of treatment with the diabetes drug pioglitazone. The goal is to understand how the…

This study looks at how well different forms and doses of daily aspirin work in people with type 2 diabetes to prevent blood clots. About 30 participants will first take a standard coated aspirin for a week. Those whose blood does not respond well will then try three other aspiri…

This study looks at how much people with type 2 diabetes know about nutrition and how closely they follow the Mediterranean diet. Researchers will give questionnaires to 500 patients at an outpatient clinic. The goal is to see if better diet knowledge leads to healthier eating an…

This study is building a questionnaire to measure how actively people with type 2 diabetes manage their health. Researchers will test the tool with 600 patients and healthcare workers to ensure it is accurate and reliable. The goal is to identify different patterns of health beha…

This small early-phase study is testing whether a drink containing ketone esters can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days, and researchers will use heart s…

This study looks at whether teaching digital skills to Latino adults with type 2 diabetes while they are in the hospital helps them use online patient portals and telehealth after they go home. Participants will get one-on-one training from a digital navigator, while others recei…

This study follows 1000 adults with type 2 diabetes who have already had a heart CT scan. Researchers will repeat the scan to measure how fatty plaque builds up in heart arteries over time. The goal is to better understand which patients are at highest risk for heart attacks, wit…

This study looks at whether a natural process called autophagy (cell cleanup) is reduced in people with type 2 diabetes and if that harms small blood vessels. About 60 adults (some with diabetes, some healthy) will take either trehalose (a sugar that may activate autophagy) or a …

This study looks at whether high or moderate intensity exercise is better for the brain in people with type 2 diabetes. 75 participants will exercise for 6 months, three times a week, and have brain scans, thinking tests, and blood draws before and after. The goal is to see how e…

This study looks at why people with pre-diabetes or type 2 diabetes feel more tired and weak in their legs during exercise. Researchers think it may be due to blood vessel problems. They will test a special exercise program that uses blood flow restriction to better understand th…

This study looks at how antipsychotic drugs might disrupt insulin action in the brains of healthy young women, and how this changes across the menstrual cycle. Fifteen participants will receive olanzapine or a placebo, plus intranasal insulin, and undergo MRI scans. The goal is t…

This study uses a new type of heart MRI scan with a special dye (manganese) to take detailed pictures of the heart. Researchers want to learn why people with both heart failure with preserved ejection fraction (HFpEF) and type 2 diabetes often have worse outcomes. They will compa…

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way cells in the pancreas work in people with type 1 or type 2 diabetes. Researchers want to understand a natural hormone called GLP-1 that helps manage blood sugar. About 60 adults o…

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how well blood sugar is controlled and whether it affects transplant outcomes like wound healing or complication…

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver. Researchers will compare glucose production during rest and exercise in 12 adults aged 25-55. The goal is to understand how exercise might help control blo…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This study is like a big health check-up for 600 U.S. Army soldiers. Researchers will look at what they eat, their heart health, body composition, mental well-being, and physical fitness. The goal is to gather information to help improve soldier health and readiness, not to test …

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans and physical tests to see how the drug affects muscle mass and function. The goal is to understand risks of muscle loss an…

This study follows 930 young people aged 12 to 25 over up to 25 years to learn how type 2 diabetes affects heart and blood vessel health. Participants include those with diabetes, overweight but not diabetic, and healthy lean individuals. They will have yearly 4-day visits with t…

This study looks at different ways to help teenagers and young adults with type 2 diabetes and their families address social needs like food or housing. About 104 participants will attend regular clinic visits, complete surveys, and be connected to community resources. The goal i…

This study looks at whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages can help them become more active and improve their health. About 36 adults who are not very active will wear a Fitbit and answer texts for 12 weeks. The goal is to …