TYPE 2 DIABETES

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study tests whether a fully closed-loop insulin system (which automatically adjusts insulin delivery) works better than a standard insulin pump for people with type 2 diabetes. Eighty adults who have used an insulin pump for at least six months will try both methods for 12 w…

This study compares two advanced heart procedures—stenting guided by imaging and blood flow tests (PCI) versus bypass surgery (CABG)—in 1,500 people with diabetes and three blocked coronary arteries. The goal is to see which approach better prevents major events like death, heart…

This study tests whether meals designed for South Asian and Filipino cultures, following diabetes guidelines, can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for a month while eating their usual diet and t…

This Phase 2 trial tests an experimental drug called LY3457263 in 240 adults with type 2 diabetes who still have high blood sugar despite taking stable doses of semaglutide or tirzepatide. Participants receive weekly injections of either the new drug or a placebo for about 9 mont…

This study compares two different strength training schedules—non-linear and linear periodization—in people with type 2 diabetes. Over 8 weeks, 48 participants will do supervised workouts three times a week or receive usual care. Researchers will measure changes in exercise capac…

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned…

This study tests two higher doses (3.0 mg and 4.5 mg) of the diabetes drug dulaglutide in teenagers aged 10 to 17 with type 2 diabetes. The goal is to see if these doses are safe and help control blood sugar and weight. Participants will receive weekly injections for about 8 mont…

This phase 2 trial tests clofutriben, a drug that lowers cortisol, in 1500 adults with hard-to-control type 2 diabetes and signs of high cortisol. Participants receive either clofutriben or a placebo daily for 24 weeks. The study measures changes in blood sugar and cortisol level…

This study tests a new daily pill, icovamenib, for people with type 2 diabetes who still have high blood sugar despite taking Ozempic. About 60 adults will receive either the pill or a placebo for 12 weeks. The main goal is to see if the pill lowers HbA1c (a measure of blood suga…

This study looks at whether THC, the active part of marijuana, can change how the body handles sugar and affects blood vessel health in people with type 2 diabetes. About 30 adults will take THC or a placebo for two weeks, then have their blood sugar and blood vessel function tes…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This study tests whether a special nutritional supplement, designed using artificial intelligence, can help adults with type 2 diabetes lower their blood sugar over 24 weeks. One hundred participants will receive either the active supplement or a placebo, alongside their usual di…

This study looks at whether adding menopausal hormone therapy to a GLP-1 drug (semaglutide) improves blood sugar control in early postmenopausal women who have or are at risk for type 2 diabetes. About 96 women with menopausal symptoms and a BMI of 27 or higher will be enrolled. …

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests whether a special high-protein shake can help overweight or obese adults with type 2 diabetes preserve lean muscle mass when they start taking GLP-1 drugs like Ozempic or Mounjaro. About 60 participants will be randomly assigned to drink the shake or follow stand…

This Phase 3 study tests whether a new drug called CagriSema helps people with severe obesity (with or without type 2 diabetes) lose more weight than the existing drug semaglutide. About 2,500 participants will receive either CagriSema or semaglutide for 83 weeks. The main goal i…

This study is testing whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages from an AI chatbot can help them become more active and improve their health. Thirty-six sedentary adults will wear the Fitbit daily for 12 weeks and receive week…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This Phase 3 trial tests an experimental drug called HM11260C in adults with type 2 diabetes whose blood sugar is not well controlled with metformin and dapagliflozin. About 118 participants will receive either HM11260C or a placebo, and researchers will measure changes in HbA1c …

This Phase 2 trial tests whether a new drug called icovamenib can help people with type 2 diabetes who still have high blood sugar despite taking other medications. About 60 adults aged 18 to 70 will receive either icovamenib or a placebo daily for 12 weeks. The main goal is to s…

This study explores whether spending time in the cold enough to shiver can improve how the body handles sugar in people with type 2 diabetes. Fifteen adults aged 40-75 with type 2 diabetes will undergo 10 days of cold exposure with shivering. Researchers will measure changes in i…

This study tests whether adding communication counseling to a step-tracking program helps couples where one partner has type 2 diabetes walk more and improve blood sugar. About 200 couples will use Fitbits and get step goals. Half will also attend counseling sessions to improve t…

This study tests two ways to help Chinese immigrants with type 2 diabetes control their blood sugar: watching educational videos, or videos plus a community health worker. 540 adults in NYC will join. The goal is to see if these tools lower HbA1c levels and boost confidence in ma…

This study compares two diabetes medications, enavogliflozin and pioglitazone, when added to standard metformin treatment. It includes 120 adults with type 2 diabetes whose blood sugar is not well controlled. The goal is to see which drug works better at lowering blood sugar and …

This study compares two medications, clopidogrel and cilostazol, to see if they can slow down the buildup of plaque in the neck arteries of people with type 2 diabetes. The goal is to prevent future heart attacks and strokes. About 120 adults with diabetes and early signs of arte…

This early-stage trial is testing a new drug, HMS1005, in 40 people with type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. Researchers will also look at how it affects blood sugar levels over 24 hours. Participants will receive either the…

This study tests whether GLP-1 receptor agonists, a class of diabetes medications including semaglutide, can improve heart nerve damage in people with type 2 diabetes. 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers w…

This 12-month pilot study tests whether a nurse-led smartphone app can help Medicaid patients with insulin-treated type 2 diabetes improve their blood sugar control. The program combines educational messages, phone-based problem-solving with a nurse, and remote monitoring via a d…

This study tests whether using a continuous glucose monitor (CGM) for short periods, combined with personalized feedback, helps adults with type 2 diabetes control their blood sugar better than standard finger-prick testing. About 400 participants will be randomly assigned to eit…

This early-stage study tests how a new medicine, NNC0487-0111, affects insulin sensitivity and pancreas function in adults with type 2 diabetes. About 80 participants will receive either the study drug or a placebo. The goal is to see if the drug can help the body use insulin bet…

This Phase 2 trial tests HP-211, a botanical extract from common vegetables like endive and lettuce, in 300 people with type 2 diabetes. The goal is to see if it can improve how the body uses insulin and lower blood sugar levels over 90 days. Participants take HP-211 or a placebo…

This pilot study tests whether having a pharmacist oversee continuous glucose monitoring (using a FreeStyle Libre device) can improve blood sugar control and health behaviors in people with type 2 diabetes. Forty participants will use the monitor for 12 weeks, and their results w…

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This Phase 1 trial tests a new injectable drug called SHR-3167 in 55 adults with type 2 diabetes. The study measures how the drug moves through the body and how well it controls blood sugar. Participants will receive either SHR-3167 or insulin degludec to compare their effects an…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study tests whether an AI app called SnapD, which recognizes Thai food and estimates nutrition, can help people with type 2 diabetes and overweight improve their blood sugar control. Some participants will also use a continuous glucose monitor (CGM) that tracks sugar levels …

This study tests whether semaglutide (Ozempic), a drug used for type 2 diabetes, works well for people with spinal cord injury (SCI) who also have diabetes. SCI patients are at higher risk for diabetes, but it's unclear if standard treatments are effective. The trial will measure…

This study tests whether an AI-enhanced digital tool called iMatter2 can help people with type 2 diabetes better manage their condition. About 353 participants will use the tool to report their symptoms and receive feedback, while researchers track changes in blood sugar levels o…

This study tests a program called Glycemic Excursion Minimization (GEM) for people newly diagnosed with type 2 diabetes. Participants use a continuous glucose monitor to see how food and activity affect their blood sugar, then make personalized changes. The goal is to lower blood…

This study tests a program that gives fresh fruits and vegetables to Native American adults aged 55 and older who face food insecurity and have type 2 diabetes or are at risk. Participants receive vouchers to buy healthy food at local centers, along with nutrition education. The …

This study tests whether a structured lifestyle program, including a total diet replacement phase, can help Malaysian adults with early type 2 diabetes achieve remission. 92 participants will be randomly assigned to either the intensive program or standard care. The goal is to se…

This study tests whether specially trained community pharmacists can help people with type 2 diabetes and early kidney disease start and stick with medications that protect the kidneys and heart. The trial will include 120 adults in Nova Scotia who don't have a family doctor. Par…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests whether 12 weeks of high-intensity interval training (HIIT) can improve how muscles store sugar (glycogen) and use insulin in people with type 2 diabetes. Researchers will also check if HIIT reduces liver fat. The trial involves 36 overweight or obese adults aged…

This study tests whether short, controlled sessions of low oxygen (intermittent hypoxia) can improve blood flow to the brain and memory in adults aged 60-85 with type 2 diabetes. Researchers will compare the training to a placebo in 80 participants. The goal is to find a new way …

This study tests whether weekly diabetes education videos sent by text message, plus help from a community health worker, can improve blood sugar control in Chinese immigrants with type 2 diabetes. 270 participants in New York City will be randomly assigned to receive the program…

This study is testing whether a personalized approach to lowering 'bad' cholesterol (LDL-C) works better than standard moderate-dose statins for preventing first heart attacks, strokes, or related events in people aged 70 and older with type 2 diabetes. About 2,186 participants w…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking ski…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This study looks at whether a high-carbohydrate diet combined with exercise can help people with type 2 diabetes achieve remission. It involves 24 overweight adults recently diagnosed with diabetes who are not on insulin. The goal is to see if this approach is practical and safe,…

This study is testing whether limiting all food intake to a 10-hour window each day can help people with type 2 diabetes better manage their blood sugar. About 102 adults will follow this eating pattern for one year, tracking their first and last meals by text. Researchers will c…

This study looks at whether a 24-week program of healthy eating and exercise helps post-menopausal women with type 2 diabetes and heart-kidney problems stick to their new GLP-1 medication. Researchers will track how many women stop taking the drug and measure changes in heart dis…

This study tests whether time-restricted eating—fasting for 18 hours and eating only during a 6-hour window each day—can help preserve the pancreas's ability to produce insulin and improve blood sugar control in people with type 2 diabetes. Over 52 weeks, 112 overweight adults wi…

This study tests whether a fully automated insulin delivery system (CamAPS HX) can improve kidney oxygen levels in people with type 2 diabetes and chronic kidney disease. About 76 adults will use either the automated system or standard insulin therapy with a glucose monitor for 2…

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will track changes in blood pressure and blood sugar over 6 months in 100 adults aged 18-60. The goal is to see if home-based care leads to better control o…

This Phase 3 trial is testing whether the experimental drug HDM1005 can help people with type 2 diabetes control their blood sugar better than a placebo. About 240 adults who have not used diabetes medication for at least 12 weeks will receive either HDM1005 or a placebo injectio…

This study tests whether a 4-week online education program about continuous glucose monitors (CGMs) helps youth aged 8-21 with type 2 diabetes improve their blood sugar control compared to standard care. Participants will attend virtual sessions with a diabetes educator and use t…

This study is tracking 3000 adults with type 2 diabetes who are starting a new combination pill called Proline Plus Empagliflozin. Researchers want to see how well it controls blood sugar and if it is safe when used in everyday medical practice. The study does not change how doct…

This early study tests whether delivering focused ultrasound pulses to the liver and a nearby nerve bundle can improve blood sugar control in people with type 2 diabetes. Thirty adults on stable oral diabetes medications will receive the ultrasound treatment. The main goal is to …

This study looks at whether partly replacing animal protein with plant protein can improve blood sugar control in people with type 2 diabetes who are overweight. About 146 adults will follow either a plant-based diet or a standard healthy diet for 24 weeks. The main goal is to se…

This study compares two triple-drug combinations to see which works better for controlling blood sugar and possibly achieving diabetes remission in people newly diagnosed with type 2 diabetes. About 240 adults aged 18-65 with very high blood sugar (HbA1c ≥9%) will be randomly ass…

This study tests a diabetes program called Together Overcoming Diabetes (TOD), designed specifically for Lakota and other American Indian/Alaska Native communities. About 140 adults with type 2 diabetes who care for a young person aged 10-25 will take part. The program focuses on…

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study tests whether a mobile app called PortionSize Ed can help recent stroke survivors who also have prediabetes or type 2 diabetes follow a Mediterranean-style diet. Forty adults aged 30 to 65 will be split into two groups: one gets the full app with dietitian support, the…

This study tests a new drug called CMG190303 in 240 adults with type 2 diabetes and high cholesterol. It compares the drug's effect on blood sugar and LDL (bad) cholesterol against standard treatments. The goal is to see if the new drug works better at controlling both conditions…

This study tests whether a pharmacist-led care pathway can improve blood sugar control in 600 adults with type 2 diabetes who are not meeting their A1C targets. Participants will receive step-by-step guidance from pharmacists using a web-based tool, compared to usual care from th…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study looks at whether the diabetes drug pioglitazone can improve how the liver processes energy in people with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Researchers will measure liver mitochondrial function using special tracers before and after 16 weeks…

This pilot study tests whether two diabetes drugs—dapagliflozin and semaglutide—can reduce inflammation after a heart attack. Researchers will enroll 44 people with type 2 diabetes, obesity, and high inflammation levels. Participants will take one of the drugs for 24 weeks, and t…

This study tests whether two digital apps can help adults with type 2 diabetes who are at high risk for complications. About 120 participants will use the apps alongside standard care, while 50-100 others receive standard care alone. The study lasts 12 months and measures changes…

This study tests a new drug called HRS9531 against a placebo in 300 people with type 2 diabetes whose blood sugar is not well controlled with basal insulin. The main goal is to see if HRS9531 lowers blood sugar levels (HbA1c) more effectively after 40 weeks. Participants must be …

This study tests whether oral semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside standard care. The goal is to see if it works as well …

This study compares the usual dose of metformin (1000 mg twice a day) with a higher dose (1350 mg twice a day) in 20 youth aged 10-21 with type 2 diabetes. The goal is to see if the higher dose is acceptable and feasible, and whether it improves blood sugar control. Participants …

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The main goals are to check safety, how the body processes the drug, and to get an early look at whether it helps with weight loss or blood suga…

This study tests whether drinking whey protein before meals can help adults aged 75-90 with type 2 diabetes keep their blood sugar in a healthy range. Participants will take whey protein or a placebo before each meal for a week, and their blood sugar will be tracked continuously.…

This study looks at two ways to help people with type 2 diabetes who have trouble controlling their blood sugar. One group gets care at a day hospital, while the other works closely with a dietitian-nutritionist. The goal is to see which approach lowers HbA1c (a key blood sugar m…

This study looks at whether taking fish oil and/or metformin for 12 months can improve heart health in women with Polycystic Ovary Syndrome (PCOS). PCOS raises the risk of heart disease and diabetes. The trial will enroll 146 women with PCOS who are overweight and have high blood…

This study looks at whether a low-carbohydrate diet helps teenagers with type 2 diabetes control their blood sugar better than a standard diet. About 40 teens aged 12-18 will follow one of the two diets for 24 weeks. Researchers will measure changes in blood sugar, insulin resist…

This early-stage study tests a new medicine (NNC9733-0001) to see if it is safe and tolerable in healthy volunteers and people with type 2 diabetes. Participants receive either the study drug or a placebo as a single injection. The goal is to check for side effects and how the dr…

This study compares three types of weight-loss surgery (sleeve gastrectomy, gastric bypass, and duodenal switch) with standard medical care for people with type 2 diabetes and a BMI of 35 or higher. The goal is to see which approach leads to long-term diabetes remission and impro…

This study will follow about 470 adults with type 2 diabetes who are starting oral semaglutide as part of their normal care. Researchers will track changes in blood sugar (HbA1c) and body weight over 5 to 7 months. The goal is to see how well the medication works when prescribed …

This study looks at whether changing the dose or form of aspirin can improve blood clotting control in people with type 2 diabetes who don't respond well to standard enteric-coated aspirin. About 30 participants will try three different aspirin regimens over several weeks. The ma…

This study tests whether a digital heart health program (a web app, online classes, and special foods) added to usual care can lower cholesterol and reduce heart attacks in people with heart disease or risk factors. About 1,100 participants will be randomly assigned to the progra…

This Phase 3 trial compares a new injectable drug, GZR18, to the popular weight-loss medication Wegovy (semaglutide) in 420 adults who are obese or overweight. The main goal is to see how much weight participants lose after 52 weeks of treatment. Researchers will also check for s…

This study gives families on Medi-Cal who have a child with type 2 diabetes monthly vouchers worth $105 to buy fresh fruits, vegetables, beans, and legumes at participating markets. The goal is to see if easier access to healthy food improves blood sugar levels, food security, an…

This study tests whether adding a continuous glucose monitor (CGM) and nutrition counseling to a food-as-medicine program helps adults with type 2 diabetes and food insecurity better manage their blood sugar. Sixty participants will be split into two groups: one gets the standard…

This study tests a treatment called physiologic insulin resensitization (PIR) in 120 adults with advanced chronic kidney disease and type 2 diabetes. The goal is to see if PIR can improve kidney function better than standard care. Participants will be randomly assigned to receive…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study tests whether a mobile app that scans food barcodes and shows easy-to-read nutrition labels can help 900 adults with type 2 diabetes better manage their blood sugar. Participants will either use the app plus get standard advice, or just get standard advice. The main go…

This study tests a new oral medication, HDM1002, in 360 adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants will take either a low or high dose of HDM1002 or a placebo daily for 40 weeks. The main goal is to see if the dru…

This study tests whether switching from one diabetes medication (DPP-4 inhibitor) to another (TZD) can better control blood sugar in people with type 2 diabetes who are already taking metformin and an SGLT2 inhibitor. About 204 adults will be randomly assigned to either stay on t…

This Phase 3 trial tests whether taking dapagliflozin and telmisartan together works better than either drug alone for people with type 2 diabetes and high blood pressure. About 221 adults will receive either the combo or a single drug for 12 weeks. Researchers will measure chang…

This study is testing whether a dietary supplement called attapulgite can help people with obesity or overweight with type 2 diabetes lose weight safely. Forty participants will take either attapulgite or a placebo daily for 12 weeks. Researchers will measure changes in BMI, weig…

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study collects breath samples from 235 people with type 2 diabetes or obesity to improve a device that estimates blood sugar from exhaled air. Participants breathe into a portable analyzer that measures volatile organic compounds. The goal is to gather data to refine the dev…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study tests whether using an AI-driven retinal camera during regular diabetes checkups can increase the number of young people screened for diabetic retinopathy, a leading cause of blindness. Researchers will enroll 500 youth with type 1, type 2, or cystic fibrosis-related d…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study is testing whether a digital tool that encourages self-reflection and healthy habits can prevent type 2 diabetes. Over 40,000 adults without diabetes will use the app or receive usual care for three years. Researchers will track how many people develop diabetes in each…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study tests a new way to screen for heart failure risk in people with type 2 diabetes. Doctors use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then offer early prevention treatments. About 300 patients are taking part. The goal is to see if this…

This study tests an online diabetes prevention program for UCLA undergraduates who are at risk for type 2 diabetes. The program includes short online lessons and aims to help participants lose weight and improve quality of life. Researchers will compare results between those who …

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This small study in Uganda looks at how meals made with local fruits and vegetables affect blood sugar and fat levels in people with type 2 diabetes. Eight participants will eat five different test meals over five weeks, with blood samples taken over three hours after each meal. …

This study looks at whether counseling sessions can help people with type 2 diabetes become more physically active and sit less. Researchers will compare standard care with informational sessions on exercise benefits, with or without practical guidance from a kinesiologist. The g…

This study tests whether taking 3 mg of melatonin each night for 8 weeks can improve sleep and daily body rhythms in people with diabetic retinopathy. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65 with type 2 diabetes and moderate eye damage. Th…

This study looks at whether a ketone ester supplement can improve heart function and exercise ability in people with type 2 diabetes. About 30 adults will take either the supplement or a placebo and undergo heart scans and fitness tests. The goal is to see if this simple drink ca…

This study tests a virtual health coaching program for adults with type 2 diabetes who also face mental health challenges like anxiety or diabetes distress. Participants receive weekly coaching calls, support from a care team, and online tools to help manage both conditions. The …

This study tests a program that gives people with diabetes a continuous glucose monitor (CGM) when they leave the hospital. The goal is to see if it makes patients more satisfied and improves their quality of life. About 37 adults with Type 1 or Type 2 diabetes who use insulin wi…

This study tests whether adding antimicrobial photodynamic therapy (aPDT) – a light-based treatment – to standard gum cleaning can reduce bad breath (halitosis) in people with type 2 diabetes and advanced gum disease. Thirty-two participants will receive either standard care or s…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study tests a 6-week virtual program called the Diabetes Body Project 2, designed to prevent eating disorders in women aged 18-40 with type 2 diabetes. The program includes weekly group sessions and home exercises to improve body image and reduce disordered eating. Researche…

This study looks at whether using a foam roller on the feet and calves before exercise can improve foot function, balance, and walking in people with type 2 diabetes. About 40 adults aged 30 to 65 with controlled diabetes will either do exercise alone or exercise plus foam-roller…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This pilot study tests whether walking on a treadmill with a blood pressure cuff around the legs (blood flow restriction) is safe and helpful for people with type 2 diabetes. Sixty participants will either walk with or without the cuff for 6 weeks. Researchers will measure how ma…

This study provides free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers will track changes in blood sugar levels and quality of life over time. The goal is to see if easier access to CGM technology helps patients manage their d…

This study tests whether shared medical appointments—where teens with type 2 diabetes meet their doctor in a group setting with educational activities—are a good way to deliver care. 160 teens aged 12-18 will either receive standard care or attend quarterly group clinics. Researc…

This study tests whether taking krill oil supplements for 12 weeks can improve muscle strength and function in adults with long-term conditions like diabetes, heart disease, or arthritis. Thirty participants will be randomly assigned to receive either krill oil or a placebo. Rese…

This study tests whether eating all meals within an early 8-hour window (and cutting calories by 25%) can improve blood sugar and heart health in people who are overweight and have prediabetes, type 2 diabetes, or normal blood sugar. Thirty participants will try either early or l…

This study follows 600 Indigenous families in Manitoba to understand how maternal health, genetics, and early-life environment contribute to obesity and type 2 diabetes in children. Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes are enrolled, and their …

This study investigates whether 6 weeks of treadmill walking with blood flow restriction cuffs on the legs can improve immune cell function in adults with type 2 diabetes. Participants walk three times per week, with some wearing inflatable cuffs that partially limit blood flow. …

This study explores the link between sleep duration and blood sugar control in adolescents aged 12-20 with type 2 diabetes. Researchers will first measure sleep and blood sugar in 67 teens, then test a program using Fitbits and text messages to encourage longer sleep in 15 teens …

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and pover…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study will give 100 adults with diabetes a thermal camera that attaches to their smartphone to take daily pictures of their feet. The goal is to collect temperature data and see if hot spots can predict where foot ulcers might form. Participants will use the device at home f…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will follow 104 overweight adults, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will f…

This observational study is gathering detailed metabolic data from 25 adults with insulin-dependent type 2 diabetes. After drinking a standard liquid meal, participants will have frequent blood tests to measure glucose, insulin, and other markers. They will also wear continuous g…

This study looks at how an FDA-approved diabetes drug, Canagliflozin (Invokana), might protect the kidneys in people with type 2 diabetes. Twenty adults aged 18-80 with type 2 diabetes for at least 3 years will take the drug daily for 6 months. Researchers will use kidney biopsie…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study looks at how cutting calories affects the way the liver processes amino acids, sugars, and fats in people with type 2 diabetes. Researchers want to see if weight loss helps the liver respond better to a hormone called glucagon. About 20 adults with type 2 diabetes and …

This study is recruiting 3,000 adults with type 2 diabetes to collect basic health information and a small blood sample. The goal is to identify people who may be eligible for other clinical trials. No experimental treatment is given. Participants simply help researchers understa…

This study is looking for early warning signs of diabetes and its complications. Researchers will give a high-fat drink to 150 adults (ages 50-70) with prediabetes, type 2 diabetes, or healthy blood sugar. They will measure fats and inflammation in the blood before and after the …

This early study looks at how two diabetes drugs, empagliflozin and pioglitazone, interact in the body. Researchers want to see if pioglitazone can reduce the ketones (a type of acid) that empagliflozin sometimes produces. The study involves 64 adults with type 2 diabetes and mea…

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This study aims to find out how many adults with type 2 diabetes experience severe diabetes-related distress—a feeling of being overwhelmed by the demands of managing the disease. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their em…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

This study looks at how well the pancreas can produce insulin in people with type 2 diabetes. Participants drink a meal replacement shake, and blood is taken five times over two hours to measure insulin and blood sugar levels. The goal is to understand differences in insulin prod…

This study looks at how a 12-week physical activity program, delivered through smartphone apps and a Fitbit, affects brain function in cancer survivors who report 'chemo-brain' (cognitive problems after chemotherapy). Researchers will compare survivors with and without type 2 dia…

This study uses advanced MRI scans with a special manganese dye to look at how the heart handles calcium and energy in people with heart failure with preserved ejection fraction (HFpEF). Researchers will compare 40 people with HFpEF (half with type 2 diabetes) and 20 healthy volu…

This study tests different ways to help teenagers and young adults with type 2 diabetes address social needs like food or housing. About 104 teens and their caregivers will try either tailored resource lists or a universal empowerment approach. The goal is to see which method is …

This study looks at how a 12-week exercise program affects the way older adults (over 65) with type 2 diabetes use protein from their diet. Thirty participants will do moderate-to-vigorous aerobic and strength training, and researchers will measure changes in protein balance, gut…

This study uses advanced MRI scans to track changes in muscle and fat in the body and heart over 12 months in 50 adults starting semaglutide for type 2 diabetes or weight loss. Participants will undergo MRI scans, physical tests, blood samples, and questionnaires. The goal is to …

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver disease. Researchers will measure liver sugar production during rest and exercise in 12 adults aged 25-55. The goal is to better understand how exercise hel…

This study aims to create a questionnaire that measures how actively people with type 2 diabetes manage their health. Researchers will test the tool with 600 patients and healthcare workers to ensure it is accurate and reliable. The goal is to better understand patients' behavior…

This study looks at 3,000 people with type 2 diabetes to see if certain signs of inflammation in the blood are linked to diabetes-related health problems. Researchers hope to find early clues that could help identify patients at higher risk for complications. The study is purely …

This study follows 800 adults with type 2 diabetes to see how their lifestyle choices relate to long-term complications like heart or kidney problems. Researchers will track participants over time and record any complications that develop. The goal is to find early warning signs …

This study looks at how a person's genetic makeup influences their response to oral semaglutide (Rybelsus), a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes a 14-day course of the drug and measure blood sugar, insulin, and other factors after a s…

This study looks at how antipsychotic drugs might cause metabolic problems in women by affecting how the brain responds to insulin. Researchers will give 15 healthy women a single dose of the antipsychotic olanzapine and insulin nasal spray, then use brain scans to see changes. T…

This study looks at how different exercise intensities affect the brain in people with type 2 diabetes. 75 inactive adults aged 30-75 will do supervised cycling at high or moderate intensity for 6 months, three times a week. Researchers will use brain scans, cognitive tests, and …

This study is observing 3000 adults with type 2 diabetes in Italy to see how well their heart risks are managed according to current guidelines. Researchers will check if patients are getting the right medications and care. No new treatments are being tested.

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome by analyzing immune cells from a blood sample. Researchers will compare calcium and inflammation signals in these cells between patients with and without heart probl…

This early-stage study looks at how taking a new tablet called CX11 with or without food changes the amount of drug in the blood. It involves 32 healthy adults and does not aim to treat any disease. The results will help researchers decide how to give the drug in future studies f…

This study looks at how exercise affects insulin resistance and heart function in people with type 2 diabetes. Researchers will have 150 participants do 15 weeks of cardiovascular exercise, 3 times a week. They will measure changes in oxygen use and insulin sensitivity to see if …

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure the fat and see how it relates to the cells that make insulin. The goal is to better u…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study looks at why having low 'bad' cholesterol (LDL) might actually increase the risk of type 2 diabetes. Researchers think LDL entering fat tissue may cause problems that lead to diabetes. They will test if taking omega-3 fish oil supplements for 6 months can reduce that r…

This study is looking for early warning signs in the blood that could predict chronic heart failure in people with type 2 diabetes. Researchers will follow 500 participants over time, using heart scans and blood tests to see if certain biomarkers can spot trouble before symptoms …

This observational study will follow 1,000 people with type 2 diabetes for one year to see if changes in the eye's blood vessels and tissues can predict worsening diabetic retinopathy and related heart problems. Researchers will use advanced imaging and medical records to track e…

This study is surveying 500 adults with type 2 diabetes to see how much they know about nutrition and how closely they follow the Mediterranean diet. Researchers will also measure blood sugar, cholesterol, and muscle strength. The goal is to understand the link between diet knowl…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study uses advanced full-body PET scans to see how natural gut hormones (GIP and GLP-1) affect how the body takes up sugar and blood flow. It includes healthy adults and people with type 2 diabetes. The goal is to better understand how these hormones work after eating, which…

This study looks at how the body processes arginine, a natural nutrient, in teenagers with type 2 diabetes. Researchers will give participants arginine and measure its effect on insulin production. The goal is to better understand the disease and see if arginine could be a safe, …

This study looks at how tiny particles called extracellular vesicles affect blood flow in people with type 2 diabetes. Researchers will test whether 16 weeks of supervised treadmill exercise can change these particles and improve vascular function. The goal is to understand how e…

This early-phase study is testing whether a drink containing ketones can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days while researchers measure heart efficiency wi…

This study looks at 100 adults with type 2 diabetes who were admitted to the ICU with severe lactic acidosis. Researchers want to see if taking metformin before admission affects their chances of survival. The goal is to better understand the role of this common diabetes drug in …

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for type 2 diabetes and fatty liver. Thirty adults with obesity, diabetes, or fatty liver will eat a high-fructose or high-glucose diet for 12 days, then swit…

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…

This study looks at whether the chemicals in your breath change throughout the day and if those changes are different for people with diabetes. Researchers will measure breath samples from 60 adults—some without diabetes, some with type 1, and some with type 2. The goal is to lea…

This study will use a special MRI scan to look at the health of multiple organs in 1,000 adults with type 2 diabetes who have not had heart problems. Researchers want to see if these scans can predict future heart attacks, strokes, or kidney disease over five years. The goal is t…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

People with type 2 diabetes are at high risk for heart disease. This study will follow 1,000 such patients who have already had a heart CT scan. Researchers will repeat the scan and track how plaque buildup in the heart's arteries changes over time. The goal is to better understa…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study will assess the diet, heart health, body composition, mental wellbeing, and physical performance of 600 U.S. Army soldiers. Researchers aim to gather detailed data on nutrition and health, similar to a national survey but tailored for the military. The goal is to bette…

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how blood sugar control relates to complications like wound healing or other transplant outcomes. Participants m…

This study follows 300 people who are having weight-loss (metabolic) surgery to see how their gut bacteria change over time and how those changes relate to heart health, diabetes, and cholesterol. Participants provide blood and stool samples before surgery and at several follow-u…

This study looks at whether a natural cell process called autophagy (cell cleanup) is reduced in people with type 2 diabetes and if that harms small blood vessels. Sixty adults with and without diabetes will take either trehalose (a sugar that may boost autophagy) or a placebo fo…

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way the pancreas works in people with type 1 or type 2 diabetes. Researchers will measure hormone levels before and after treatment. The goal is to understand how these treatments aff…

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy u…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study tests whether teaching Latino patients with type 2 diabetes how to use patient portals and telehealth during a hospital stay helps them manage their care after discharge. 84 adults will receive either one-on-one digital training or standard care. The main goal is to se…

This study uses ultrasound to measure the size and appearance of leg nerves in people with type 2 diabetes who have nerve damage (diabetic polyneuropathy). Researchers will then test how these nerve measurements relate to balance, walking, and daily life. The goal is to better un…

This study aims to understand how fat buildup in the pancreas (pancreatic steatosis) is linked to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat and compare it with blood sugar and other metabolic tests. 100 a…

This study investigates how red blood cells influence heart attack risk in people with type 2 diabetes. Researchers will collect blood from 500 participants (patients with heart attacks, type 2 diabetes, and healthy volunteers) and test the cells in the lab to understand their ef…