Could a diabetes drug also protect the brain? new trial aims to find out

NCT ID NCT07083154

Recruiting now Disease control Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking skills and daily function over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mazdutide (a weekly injection that targets two gut hormones to control blood sugar and possibly protect the brain)
What this could lead to: If it works, this could point toward a new treatment that slows memory loss and thinking problems in people with type 2 diabetes and early dementia.
What could go wrong: This is a Phase 3 trial, but it's still experimental. The drug may not improve cognition, and side effects like nausea or digestive issues are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction dementia follicular lymphoma type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEMENTIA, MILD MILD COGNITIVE IMPAIRMENT TYPE 2 DIABETES

Contacts and locations

Locations

Department of Endocrinology, Changzhou No.2 People's Hospital
RECRUITING

Changzhou, Jiangsu, China
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center,Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
RECRUITING

Nanjing, Jiangsu, 210008, China
Department of Endocrinology, Huadong Hospital Affiliated to Fudan University
RECRUITING

Shanghai, 200040, China
Department of Endocrinology, Jiangsu Province Hospital of Traditional Chinese Medicine
RECRUITING

Nanjing, Jiangsu, China
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University
RECRUITING

Nanjing, Jiangsu, 210000, China
Department of Endocrinology, Shanghai General Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200080, China
Department of Endocrinology, Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410008, China
The Second Affiliated Hospital of Dalian Medical University
NOT_YET_RECRUITING

Dalian, Liaoning, China

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