The Affiliated Nanjing Drum Tower Hospital Of Nanjing University Medical School

This study compares robot-assisted, minimally invasive surgery to traditional open surgery for removing large blood clots in the brain caused by hemorrhagic stroke. About 198 adults with a large basal ganglia hemorrhage will be randomly assigned to one of the two surgical methods…

This early-phase study tests whether infusing a woman's own specially prepared natural killer cells into her uterus can improve fertility and pregnancy success. It includes women with recurrent miscarriage, unexplained infertility, or repeated IVF failure linked to abnormal uteri…

This early-phase study tests a new treatment called CHT101, which uses specially engineered immune cells (CAR-T cells) to target and attack lupus-causing cells. It is for people with lupus that has not responded to standard treatments. The main goals are to see if it is safe and …

This study tests whether the anti-inflammatory drug ketorolac can improve outcomes for 360 people undergoing emergency surgery for a severe aortic tear (Stanford Type A aortic dissection). Participants receive either ketorolac or a placebo before and after surgery, alongside stan…

This study tests a second-line treatment for people with advanced pancreatic cancer that has spread and no longer responds to initial chemotherapy. Participants receive a combination of chemotherapy (nal-IRI/5-FU/LV), an immunotherapy (PD-L1 inhibitor), and a targeted anti-angiog…

This study tests a new weekly injection (mazdutide) in 420 people with type 2 diabetes who also have mild cognitive impairment or early dementia. The goal is to see if the drug can slow down memory and thinking problems over 76 weeks. Participants are randomly assigned to receive…

This study tests if the drug efsubaglutide alfa can help people who are still obese 6 months after metabolic surgery lose more weight. About 60 adults aged 18-55 with a BMI of 28 or higher will receive either the drug or a placebo. The main goal is to see how much weight they los…

This study tests a combination of the immunotherapy drug tislelizumab and chemotherapy (APF) followed by surgery or radiation for people with advanced head and neck tumors. The goal is to see if this approach can shrink or eliminate tumors and improve outcomes. About 29 adults ag…

This study is observing how well a combination diabetes pill (Proline Plus Empagliflozin) works in everyday medical practice. Researchers will track blood sugar control in 3,000 adults with type 2 diabetes over 24 weeks. The study does not change how doctors treat patients—it sim…

This early study tests a treatment using a patient's own fat cells to help women with infertility caused by a very thin uterine lining or scarring. The goal is to see if this therapy can thicken the lining enough to support pregnancy. Ten women who have not responded to other tre…

This study tests whether colchicine, a common anti-inflammatory drug, can reduce organ damage after heart surgery. About 768 adults aged 50-80 having planned heart surgery will receive colchicine or a placebo. Researchers will measure heart, lung, and kidney injuries, as well as …

This study tests a new vaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer patients who have had surgery and chemotherapy but are at high risk of their cancer returning. The vaccine is designed to train the immune system to attack…

This study is testing whether a drug called aniracetamfen can safely reduce pain and help people recover faster after a major pancreatic surgery called pancreaticoduodenectomy. About 35 adults who need this surgery will receive the drug and be monitored for pain levels, complicat…

This study looks at how well two different pain medicines—acetaminophen (Tylenol) and hydromorphone (Dilaudid)—work for sudden chest pain. About 30 adults with severe chest pain will receive one of these drugs through an IV, and their pain levels will be checked over an hour. The…

This study looks at tiny particles called exosomes in the blood of people who have had a sudden cardiac arrest. Researchers want to see if certain molecules in these particles can help predict who is at risk. The goal is to find better ways to identify high-risk patients early an…

This study follows 300 adults with end-stage heart failure who receive a left ventricular assist device (LVAD) as part of their standard care. Researchers will track survival, complications, and hospital readmissions for 3-5 years. They will also study heart tissue and blood samp…

This study aims to understand how the brains and metabolisms of people with obesity react differently to sugar, fat, and protein compared to people without obesity. Researchers will give 60 participants liquid meals and use brain scans and blood tests to measure their responses. …