The Affiliated Nanjing Drum Tower Hospital Of Nanjing University Medical School

This trial investigates whether combining a targeted radioactive drug (177Lu-PSMA-617) with a hormone therapy (darolutamide) before surgery can improve outcomes for men with high-risk localized prostate cancer. Participants receive two doses of the radioactive drug and daily horm…

This study tests whether metformin, a standard diabetes medicine, can improve heart function in people who have received a mechanical heart pump (LVAD) for severe heart failure. Researchers will give metformin or a placebo to 108 patients for 12 months and check heart function, b…

This study looks at 120 adults with moderate-to-severe psoriasis who take secukinumab, a biologic drug. It compares two maintenance schedules: the standard every-4-week injection versus a non-standard schedule (longer intervals or lower dose). The goal is to see which schedule ke…

This study tests whether a mild electrical stimulation applied to the ear (via a small device) can improve memory and thinking in people with type 2 diabetes who also have mild cognitive impairment. The trial will involve 38 participants who will either receive the active stimula…

This early-stage trial tests whether starting a specific type of blood filtering (hemodiafiltration) immediately after a standard blood-cleaning treatment (hemoperfusion) can improve survival in people with severe diquat poisoning. Diquat is a herbicide that can cause rapid kidne…

This early study tests whether a personalized mix of viruses (called phages) can safely treat urinary tract infections caused by drug-resistant bacteria. Six adults aged 18–65 will receive the phage cocktail through a catheter every 12 hours for 2–3 days. Researchers will monitor…

This study compares a newer flow-diverting stent to standard stent-assisted coiling for treating unruptured brain aneurysms in the middle cerebral artery. About 140 adults aged 18-70 will be randomly assigned to one of the two procedures. The main goal is to see which method more…

This study compares two ways to remove small rectal neuroendocrine tumors (less than 1 cm). The new method, called modified double snare EMR, is expected to be just as effective as the standard ESD procedure but with shorter operation time, fewer complications, and lower cost. Ab…

This phase II trial tests a personalized approach for people with advanced liver cancer that cannot be removed by surgery. Researchers will classify each patient's tumor by its fatty acid degradation (FAD) subtype and assign either a drug combination (camrelizumab plus apatinib) …

This study tests a new combination of the drug entinostat plus standard chemotherapy for people with advanced bladder cancer that has spread or cannot be removed by surgery and has not responded to first-line treatment. About 29 participants will receive the combination to see if…

This phase 2 trial tests a combination of two drugs (carilizumab and apatinib) plus radiation therapy as a first treatment for advanced mucosal melanoma, a rare and aggressive skin cancer. The study will enroll 30 adults who have not had prior systemic therapy. Researchers will m…

This study tests whether a woman's own immune cells, turned into decidual-like NK cells in a lab and then placed back into her uterus, can improve pregnancy chances. It includes 159 women with abnormal uterine NK cells and a history of reproductive failure. The main goal is to se…

This study compares two approaches to dialysis in people who have been severely poisoned by the herbicide diquat. One group starts dialysis right away after a blood-cleaning procedure, while the other waits until kidney damage appears. The goal is to see if earlier dialysis reduc…

This study checks if a new portable device can accurately measure diquat (a toxic herbicide) in blood samples from 60 people with suspected poisoning. The goal is to see if the new method matches the standard lab test. If successful, it could help doctors diagnose poisoning faste…

This study tests whether a gentle electrical current applied to the brain (tDCS) combined with hand exercises can improve hand function in people who had a stroke. Fifty-six participants will receive either real or sham tDCS for 20 sessions over four weeks. Researchers will use M…

This study tests if taking fish oil by mouth can prevent or lessen nerve damage (peripheral neuropathy) caused by the chemotherapy drug bortezomib in people with multiple myeloma. Researchers will compare nerve health in 200 patients who take fish oil versus those who don't. The …

This study will use artificial intelligence to create a risk prediction model for head and neck cancers, including cancers of the throat and voice box. Researchers will collect data from 3000 participants, including their medical history, lifestyle habits, and laryngoscopy images…