Handheld ultrasound could spot hidden graft failures during bypass surgery
NCT ID NCT07700524
First seen Jul 14, 2026 · Last updated Aug 12, 2026 · Updated 3 times
Summary
This trial tests whether using a portable ultrasound device during coronary artery bypass surgery can improve outcomes by letting surgeons see blood flow through the new grafts in real time. About 380 adults scheduled for elective bypass surgery will be randomly assigned to either standard care or standard care plus ultrasound monitoring. The study will compare rates of major complications like heart attack, stroke, kidney failure, and death, as well as how often ultrasound detects graft problems that need fixing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- intraoperative portable Doppler ultrasound
- What this could lead to
- If successful, this approach could become a standard tool during bypass surgery to catch and fix blood flow problems immediately, potentially reducing complications.
- What could go wrong
- This is a single-center trial with 380 patients, so results may not apply to all hospitals. The ultrasound adds time and training, and its benefit over standard surgical judgment is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 190 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will consist of adults undergoing elective isolated coronary artery bypass grafting in the Department of Cardiac Surgery at Nanjing Drum Tower Hospital. Consecutive patients meeting the eligibility criteria will be screened and enrolled after providing written informed consent.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18 years or older. * Confirmed coronary artery disease and scheduled to undergo elective isolated coronary artery bypass grafting at Nanjing Drum Tower Hospital. * Able and willing to provide written informed consent before any study-specific procedures are performed. Exclusion Criteria: * Urgent, emergency, or salvage coronary artery bypass grafting. * Prolonged preoperative fasting, as defined in the study protocol, or inability to maintain adequate oral intake without enteral or parenteral nutritional support. * History of malignancy. * Body weight below 50 kg. * Preoperative hemodynamic instability requiring ongoing resuscitation or mechanical circulatory support, including intra-aortic balloon pump, extracorporeal membrane oxygenation, or left ventricular assist device support. * Endotracheal intubation and invasive mechanical ventilation before surgery. * Impaired consciousness, clinically significant central nervous system dysfunction, or evidence of cerebral malperfusion after hospital admission. * End-stage renal disease requiring maintenance dialysis before hospital admission. * Severe pulmonary disease considered to preclude tolerance of elective coronary artery bypass grafting or to confer an unacceptably high perioperative risk. * Severe peripheral vascular disease or clinical evidence of limb malperfusion before surgery. * History of gastrointestinal ulceration or chronic inflammatory gastrointestinal disease. * Chronic inflammatory or autoimmune disease, or long-term treatment with systemic corticosteroids or non-steroidal anti-inflammatory drugs. * Active infection or sepsis at screening. * Severe uncontrolled arrhythmia requiring urgent treatment or expected to cause marked intraoperative hemodynamic instability. * Previous cardiac surgery requiring repeat median sternotomy. * Planned concomitant major cardiac or aortic surgery, including valve surgery, congenital heart defect repair, or aortic surgery. * Inability to understand the study information or unwillingness or inability to provide written informed consent. * Inability or unwillingness to complete follow-up at 30 ± 7 days after surgery. * Pregnancy or breastfeeding.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, 210008, China
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Other studies related to the condition(s) this trial covers.
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- Hospital-to-Home transitional cardiac rehabilitation as a transition from Centre-Based cardiac rehabilitation after cardiac surgery: a Single-Blind randomised controlled trial
- Opportunistic screening of coronary artery calcium on Non-Gated routine chest CT using artificial intelligence: retrospective external validation and clinical risk stratification
- AI heart scan software aims to spot dangerous blockages without invasive probes
- A shot of nicorandil before stenting might keep blood flowing
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