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Can personalized breathing settings protect lungs during heart surgery?

NCT ID NCT07044089

Disease control Sponsor: Kocaeli University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This trial tests whether tailoring breathing support to each patient protects the lungs better than a standard fixed setting during heart bypass surgery. Researchers will compare two methods of setting positive end-expiratory pressure, or PEEP, in 86 adults having on-pump coronary artery bypass grafting. They will measure oxygen levels, lung function, and heart stability during surgery, then track breathing complications, time on a ventilator, and length of hospital stay afterward.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Individualized positive end-expiratory pressure (PEEP) guided by driving pressure, compared with a fixed PEEP level, during lung-protective ventilation
What this could lead to
If individualized PEEP works better, it could reduce lung complications and shorten hospital stays for people having heart bypass surgery.
What could go wrong
This is a single-center trial with 86 participants, so results may not apply to all patients. Individualized PEEP may not improve outcomes and could affect blood pressure or heart function during surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 86 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who will undergo elective on-pump coronary artery bypass graft surgery under general anesthesia

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy * Patients between the ages of 18 and 70 * ASA (American Society of Anesthesiologists) physical status classification II-III Exclusion Criteria: * Patients with an ejection fraction below 35% * Patients who did not consent to participate in the study * Patients undergoing emergency surgery * Patients who are allergic to the anesthetic drugs used * Patients who have undergone lung resection * Those with a history of mechanical ventilation in the 2 months before surgery * Patients who have undergone total circulatory arrest and deep hypothermia * Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance * Morbid obesity (Body Mass Index\>35kg/m2) * Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation) * COPD (FEV1\<70%) * Patients with chronic renal failure (serum creatine\>1.8 mg/dl) * Anemia (Hg\<10 gr/dl) * Patients who have had an intraaortic balloon pump placed.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peep titration in lung protective ventilation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Kocaeli University Faculty of Medicine

    RECRUITING

    Kocaeli, Izmit, 41100, Turkey (Türkiye)

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