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Can a new ventilation mode keep lungs healthier after heart surgery?

NCT ID NCT07800741

Disease control Sponsor: Koşuyolu Kartal Heart Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether a newer ventilation method, called flow-controlled ventilation, keeps the lungs and diaphragm in better shape than the standard pressure-controlled method during elective heart bypass surgery. About 154 adults scheduled for on-pump coronary artery bypass grafting will be randomly assigned to one of the two ventilation modes. Researchers will measure lung aeration using ultrasound and diaphragm function to see which method reduces postoperative complications like lung collapse and breathing difficulty.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Flow-controlled ventilation, a breathing machine mode that delivers breaths with a steady, triangular flow pattern during surgery
What this could lead to
If it works, this ventilation method could reduce lung collapse and diaphragm weakness after heart bypass surgery, helping patients breathe on their own sooner and leave the ICU faster.
What could go wrong
This is a single-center trial, so results may not apply to all hospitals. The benefits over standard ventilation may be small, and the technique requires special equipment and training.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 154 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Planned elective isolated on-pump coronary artery bypass graft (CABG) surgery * ASA Physical Status Classification II-IV * Written informed consent obtained * Technically adequate acoustic window for lung and diaphragm ultrasonography Exclusion Criteria: * Emergency surgery * Combined surgical procedures (e.g., valve repair/replacement + CABG) * Preoperative requirement for invasive or non-invasive mechanical ventilation * Known diaphragm paralysis or neuromuscular disease * Severe COPD exacerbation or active pneumonia at time of surgery * Body mass index ≥40 kg/m² * Inability to obtain standard lung or diaphragm ultrasound images due to pleural effusion, thoracic deformity, or prior thoracic surgery

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Conditions

The condition(s) this trial relates to.

coronary artery disorder diaphragm disorder Pulmonary Atelectasis respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease Diaphragm dysfunction Postoperative pulmonary complications Pulmonary atelectasis, postoperative Respiratory insufficiency

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kosuyolu Heart Training and Research Hospital

    Istanbul, Kartal, 34862, Turkey (Türkiye)

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