Diaphragm disorder

This study tests a fetal surgery called FETO for severe congenital diaphragmatic hernia (CDH), a condition where a hole in the diaphragm allows organs to crowd the lungs. Researchers will place a tiny balloon in the fetal windpipe to encourage lung growth, then remove it before b…

This study tests a procedure called FETO, done during pregnancy, for babies with a severe congenital diaphragmatic hernia (CDH). The goal is to see if FETO helps more babies survive after birth and have fewer long-term health issues compared to standard care. The study will enrol…

This trial tests a procedure called FETO, where a small balloon is placed in the windpipe of a fetus with severe left congenital diaphragmatic hernia (CDH). The balloon blocks the airway temporarily, which may help the lungs grow larger before birth. The study includes pregnant w…

This study tests a simple change at birth: instead of clamping the umbilical cord right away, doctors will keep it intact while helping the baby breathe. The goal is to see if this improves heart and lung function in full-term infants with congenital diaphragmatic hernia (CDH), a…

This study looks at a fetal surgery called FETO for babies with a severe diaphragmatic hernia, where organs move into the chest. The surgery places a balloon in the baby's windpipe to help the lungs grow, then removes it before birth. Researchers will compare 40 babies who get FE…

This pilot study tests a procedure called FETO, where a tiny balloon is placed in the fetus's windpipe to encourage lung growth. It is for pregnancies where the baby has severe left congenital diaphragmatic hernia (CDH) and very small lungs. The study will enroll 20 participants …

This study tests a procedure called FETO for unborn babies with a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm has a hole and the lungs don't grow well. Doctors place a tiny balloon in the baby's windpipe to block it, which may help the lungs expand a…

This study is tracking 245 hernia patients who receive the GORE ENFORM biomaterial mesh during surgery. The mesh is absorbable and used to reinforce the repair. Researchers will monitor hernia recurrence, infections, and other complications for up to two years. The goal is to see…

This study tests a procedure called FETO, where a tiny balloon is placed in the fetus's windpipe to help the lungs grow. It focuses on babies with severe congenital diaphragmatic hernia (CDH), a condition where abdominal organs move into the chest and stunt lung development. Rese…

This study tests a procedure called FETO for babies with a severe birth defect where the diaphragm has a hole, allowing organs to crowd the lungs. A tiny balloon is placed in the baby's windpipe while still in the womb to help the lungs grow. The study tracks how many babies surv…

This study tests a procedure called FETO in 10 pregnant women carrying babies with a severe form of congenital diaphragmatic hernia (CDH). The procedure places a small balloon in the baby's windpipe to block it, which helps the lungs grow larger before birth. The balloon is remov…

This pilot study tests a procedure called FETO in 10 unborn babies with severe left congenital diaphragmatic hernia (CDH). In CDH, a hole in the diaphragm allows organs to move into the chest, preventing normal lung growth. FETO involves placing a tiny balloon in the baby's windp…

This study tests a procedure called FETO for unborn babies with a severe diaphragmatic hernia, where organs move into the chest and harm lung growth. A tiny balloon is placed in the baby's windpipe around 27 weeks of pregnancy to help the lungs grow, then removed around 34 weeks.…

This study tests a device called STIMIT Activator 1 in 40 adults on ventilators for breathing support. The device aims to keep the diaphragm (the main breathing muscle) from weakening during ventilation. Participants are randomly assigned to receive the device or standard care, a…

This phase 3 trial tests a procedure called FETO, where a balloon is placed in the windpipe of a fetus to help lungs grow. It is for pregnant women carrying a baby with severe congenital diaphragmatic hernia, a condition where the diaphragm has a hole and organs move into the che…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether acupressure can reduce pain and improve lung function in people recovering from thoracotomy (chest surgery). Eighty participants will receive acupressure or standard care. The goal is to see if this non-drug method can cut opioid use and side effects whil…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether adding diaphragm relaxation exercises to standard spinal stabilization exercises can reduce pain and disability in people with chronic low back pain. Researchers will measure pain, quality of life, and muscle endurance in 42 adults over eight weeks. The g…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at two ways to manage pain in children having the Nuss procedure for pectus excavatum (a sunken chest). One group received standard nerve freezing (cryoanalgesia) alone, while the other also had a nerve block near the diaphragm. Researchers will compare pain scor…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study looks at why teenagers who had surgery for a diaphragmatic hernia right after birth may find it hard to take part in sports and physical activities. Researchers will interview 20 teens and their parents, and use questionnaires to identify what helps or hinders their pa…

This study tests a new, less invasive way to check diaphragm function in patients on breathing machines. Researchers will use ultrasound to measure diaphragm movement during a spontaneous breathing trial. The goal is to see if this method can help doctors decide when patients are…

This study compares four types of nerve blocks used during arthroscopic shoulder surgery to see which one causes the least temporary diaphragm paralysis and leads to better recovery. Researchers will measure breathing function, pain levels, opioid use, and overall recovery qualit…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at whether respiratory physiotherapy can prevent or reduce thinning of the diaphragm—the main breathing muscle—in patients who are on mechanical ventilators in the ICU. Researchers will measure diaphragm thickness using ultrasound in 66 adults who have been on a …

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study uses a safe, radiation-free device called electrical impedance tomography (EIT) to take pictures of the lungs in infants, children, and young adults up to age 25. Researchers will compare images from patients with chronic lung or heart conditions to healthy controls to…

This study tracks how quickly the diaphragm weakens in 15 ICU patients on mechanical ventilation. Researchers use advanced muscle tests and brain stimulation to measure changes in diaphragm function and control. The goal is to better understand ventilator-induced diaphragm dysfun…

This study looks at whether not using inhaled nitric oxide (iNO) in newborns with congenital diaphragmatic hernia (CDH) leads to better outcomes, like fewer needing life support or dying. About 600 babies from multiple hospitals will be included. The goal is to see if stopping th…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how often the diaphragm (the main breathing muscle) stops working properly after lung surgery done without a breathing tube. About 120 adults having this type of surgery will have their diaphragm checked with ultrasound right after surgery and again 24 hours l…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study aims to identify genes that make a person more likely to develop congenital diaphragmatic hernia (CDH), a birth defect where the diaphragm doesn't form properly. Researchers will collect DNA samples from 3,000 people with CDH or a family history of it, along with their…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study measures two natural amino acids, arginine and ADMA, in newborns who had abdominal surgery within their first 5 days of life. Researchers want to see if the balance of these substances can help predict how quickly a baby recovers and whether complications arise. No ext…