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New trial could change how doctors help CDH babies at birth

NCT ID NCT04429750

Recruiting now Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a simple change at birth: instead of clamping the umbilical cord right away, doctors will keep it intact while helping the baby breathe. The goal is to see if this improves heart and lung function in full-term infants with congenital diaphragmatic hernia (CDH), a rare defect where the diaphragm doesn't form properly. About 180 babies will take part across multiple hospitals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
procedure (delayed cord clamping with intact cord resuscitation)
What this could lead to
If it works, this could improve breathing and survival for newborns with a rare birth defect affecting the diaphragm.
What could go wrong
This is a mid-stage trial with 180 babies, so results may not apply to all cases. The procedure may not improve outcomes and could increase bleeding risk for the mother.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital diaphragmatic hernia Rare Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL DIAPHRAGMATIC HERNIA RARE DISEASES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Chu Amiens Picardie

    RECRUITING

    Amiens, France

  • Chu de Nantes -

    RECRUITING

    Nantes, France

  • Hop Jeanne de Flandre Chu Lille

    RECRUITING

    Lille, 59037, France

    Contact Phone: •••-•••-••••

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