Please sign in to follow a disease.
Diaphragm disorder
MONDO:0005728A disease involving the diaphragm.
Also known as: diaphragm disease, diaphragm disease or disorder, disease of diaphragm, disease or disorder of diaphragm, disorder of diaphragm, diaphragmatic disease, diaphragmatic disorder
117 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
Simple stretch may speed diaphragm recovery after heart surgery
Disease control CompletedThis study investigates whether adding a contract-relax physical therapy technique to standard respiratory care can improve diaphragm function in patients who develop diaphragmatic paresis after cardiac surgery. The trial enrolls adults who have undergone heart surgery with a hea…
Phase: NA • Sponsor: CMC Ambroise Paré • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
-
Tiny balloon inside womb could help babies breathe
Disease control CompletedThis pilot study tested a procedure called FETO, where a tiny balloon is placed in the windpipe of an unborn baby with severe congenital diaphragmatic hernia (CDH). The goal was to see if the balloon could be safely placed and removed to help the lungs grow. Four pregnant women p…
Phase: NA • Sponsor: Dr Erin Perrone • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
-
Balloon in the womb: new device aims to save babies with underdeveloped lungs
Disease control CompletedThis study tested a new device (Smart-TO) that places a small balloon in the windpipe of unborn babies with congenital diaphragmatic hernia, a condition where the diaphragm has a hole and the lungs don't grow properly. The balloon is later removed using a special MRI technique. T…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
-
Balloon in the womb may save babies with rare birth defect
Disease control CompletedThis study tested a procedure called FETO (fetal endotracheal occlusion) in 20 pregnant women whose babies had a severe form of congenital diaphragmatic hernia (CDH). In CDH, a hole in the diaphragm allows abdominal organs to move into the chest, preventing the lungs from growing…
Phase: NA • Sponsor: Michael A Belfort • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
-
Could a common heart drug save babies with a rare birth defect?
Disease control CompletedThis study looked at whether a medicine called milrinone can improve oxygen levels in newborns with congenital diaphragmatic hernia (CDH), a birth defect that causes severe breathing problems. The trial included 66 babies who were on breathing machines. The goal was to see if mil…
Phase: PHASE2 • Sponsor: NICHD Neonatal Research Network • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
-
New computer tool aims to keep Kids' diaphragms strong on ventilators
Disease control CompletedThis study tested a computer program called REDvent that helps doctors set ventilators to match a child's natural breathing effort. The goal was to prevent the diaphragm from weakening while on a breathing machine. Researchers enrolled 248 children with lung disease who needed ve…
Phase: NA • Sponsor: Children's Hospital Los Angeles • Aim: Disease control
Last updated Jun 26, 2026 18:09 UTC
-
Ultrafast ultrasound may offer quicker diagnosis for diaphragm dysfunction
Diagnosis CompletedThis study explores whether ultrafast ultrasound can accurately assess diaphragm function in adults with known or suspected diaphragm dysfunction. Researchers will compare ultrasound measurements with standard tests like pressure measurements and electrical signals from the diaph…
Phase: NA • Sponsor: Institut de Myologie, France • Aim: Diagnosis
Last updated Jul 01, 2026 00:00 UTC
-
New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
-
Less numbing medicine may keep diaphragm working during shoulder surgery
Symptom relief CompletedThis study tested whether using a smaller amount of a weaker numbing medicine (ropivacaine) during a shoulder nerve block could reduce the risk of temporary diaphragm paralysis. 60 adults having shoulder surgery took part. The goal was to see if the low-dose approach could still …
Phase: PHASE3 • Sponsor: University Hospital, Lille • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
-
Which painkiller works best after belly surgery? new study has answers
Symptom relief CompletedThis study looked at three different ways to manage pain after abdominal wall repair surgery: an epidural, a nerve block, and local injections. 160 adults who had this surgery were randomly assigned to one of the three methods. The goal was to see which approach provides the best…
Phase: PHASE4 • Sponsor: Hospital del Rio Hortega • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
-
New pain block may be safer for Kids' chest surgery
Symptom relief CompletedThis study tested two ways to manage pain in 70 children undergoing chest surgery. One method, the erector spinae plane block, was compared to the standard epidural block. The goal was to see which provides better pain relief and keeps the heart rate and blood pressure more stabl…
Phase: NA • Sponsor: Nguyen Dang Thu • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
-
Could a tiny dose of muscle relaxant make lung scopes safer?
Symptom relief CompletedThis study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…
Phase: NA • Sponsor: Harbin Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
-
Shoulder surgery pain study: which nerve block works best?
Symptom relief CompletedThis study tested two methods of numbing the suprascapular nerve (a nerve in the shoulder) to control pain after arthroscopic shoulder surgery. Sixty adults scheduled for shoulder surgery received either an anterior or posterior nerve block. Researchers measured pain levels, diap…
Phase: NA • Sponsor: Istanbul Medeniyet University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
-
Breathing training offers hope for COVID Long-Haulers with weak diaphragms
Symptom relief CompletedThis study looked at whether 6 weeks of special breathing exercises (inspiratory muscle training) can improve diaphragm strength and reduce shortness of breath in 18 COVID-19 survivors who still had trouble breathing. Participants had proven diaphragm weakness and no other explan…
Phase: NA • Sponsor: RWTH Aachen University • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
-
Physiotherapy students test muscle relief techniques on themselves
Symptom relief CompletedThis study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
-
New nerve block combo may spare breathing while killing shoulder pain
Symptom relief CompletedThis study tested two ways to numb the shoulder after surgery: the standard interscalene block and a combination of two other blocks (infraclavicular and anterior suprascapular). The goal was to see if the combination could provide equal pain relief without causing temporary diap…
Phase: NA • Sponsor: University of Chile • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
-
Breathe away the pain: simple diaphragm training may ease stubborn neck aches
Symptom relief CompletedThis study tested whether adding diaphragmatic resistance training (breathing exercises) to standard neck stabilization exercises can reduce pain and disability in people with chronic neck pain. 71 adults with neck pain lasting over 3 months did 6 weeks of home breathing exercise…
Phase: NA • Sponsor: National Cheng Kung University • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
-
Who should control your sedation during surgery? new study compares options
Symptom relief CompletedThis study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…
Phase: NA • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
-
New turkish health survey could improve care for muscle and joint problems
Knowledge-focused CompletedThis study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…
Sponsor: Istanbul Bilgi University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
-
Scientists measure healthy diaphragms to set new standard
Knowledge-focused CompletedThis study used ultrasound to measure how much the diaphragm thickens during a sniff in 60 healthy adults. The goal was to define a normal range for this measurement, which could help doctors spot diaphragm problems in the future. Participants were grouped by age and gender to se…
Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
-
Shoulder block study checks for breathing side effects
Knowledge-focused CompletedThis study observed 61 adults having shoulder surgery to see how a specific combination of nerve blocks affects the diaphragm, the main muscle for breathing. Researchers used ultrasound to measure diaphragm movement before and after the block. The goal was to find out if this tec…
Sponsor: Gazi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
-
Heart surgery patients: one in six may face hidden diaphragm trouble
Knowledge-focused CompletedThis study tracked 157 heart surgery patients to see how many still have a weak diaphragm 7 days after their operation. Using ultrasound, researchers measured diaphragm movement during breathing and sniffing. The goal is to understand how common persistent diaphragm problems are …
Sponsor: CMC Ambroise Paré • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
-
Gentler breathing during bypass may shield diaphragm after heart surgery
Knowledge-focused CompletedThis study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…
Phase: NA • Sponsor: Konya City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
-
Physios take on ER duty: study tests if they can replace doctors for back pain
Knowledge-focused CompletedThis study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…
Phase: NA • Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
-
Rare birth defect survivors: what is life really like?
Knowledge-focused CompletedThis study looked at the quality of daily life in children aged 5 to 18 who were born with a congenital diaphragmatic hernia (a hole in the diaphragm). Researchers asked the children, their parents, and siblings to fill out a questionnaire about physical and emotional well-being,…
Sponsor: Medical University of Vienna • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
-
Fetal surgery immune mystery: why do some babies arrive too early?
Knowledge-focused CompletedThis study looked at 21 pregnant women and their babies to understand how surgery before birth changes the immune system. The goal was to find out if immune system activation might cause early labor. Researchers collected blood samples and studied the placenta to track immune cha…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
-
Which arm block spares the diaphragm? new study pits two techniques Head-to-Head
Knowledge-focused CompletedThis study compared two ultrasound-guided nerve block techniques for hand, wrist, or forearm surgery to see which one causes less temporary diaphragm paralysis. 91 adults were randomly assigned to receive either a costoclavicular or lateral sagittal infraclavicular block. The goa…
Phase: NA • Sponsor: Gazi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
-
Ultrasound of breathing muscle may predict ventilator weaning success
Knowledge-focused CompletedThis study looked at whether ultrasound measurements of the diaphragm, the main breathing muscle, can help predict if ICU patients on ventilators will successfully breathe on their own. Researchers measured diaphragm thickness and movement in 60 patients before removing the breat…
Sponsor: Fatih Sultan Mehmet Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
-
Can CRPS patients imagine movement? new study investigates
Knowledge-focused CompletedThis completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
-
Scientists hunt for hidden genes behind rare birth defect
Knowledge-focused CompletedThis study looked at the DNA of 73 children with a rare birth defect called isolated congenital diaphragmatic hernia (CDH), where a hole in the diaphragm allows organs to move into the chest. Researchers wanted to find new genetic changes that might cause the condition. They used…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
-
Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
-
Can a simple nerve block prevent breathing trouble after obesity surgery?
Knowledge-focused CompletedThis study tested whether a nerve block (erector spinae plane block) can reduce diaphragm dysfunction after laparoscopic sleeve gastrectomy in severely obese patients. 80 participants were randomly assigned to receive either the nerve block or a placebo. The researchers measured …
Phase: NA • Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:09 UTC
-
Tiny study tests smarter ventilator for babies born with diaphragm defect
Knowledge-focused CompletedThis pilot study looked at 8 newborns with congenital diaphragmatic hernia (a hole in the diaphragm) after surgery. Researchers compared two types of breathing machines: standard ventilation and a newer method called NAVA, which senses the baby's own breathing signals to provide …
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:01 UTC