Tiny study tests smarter ventilator for babies born with diaphragm defect
NCT ID NCT03250793
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This pilot study looked at 8 newborns with congenital diaphragmatic hernia (a hole in the diaphragm) after surgery. Researchers compared two types of breathing machines: standard ventilation and a newer method called NAVA, which senses the baby's own breathing signals to provide synchronized support. The goal was to measure how hard the babies had to work to breathe with each machine, using a small pressure sensor in the esophagus. This early study aims to understand the physiology before testing if NAVA leads to better outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NAVA (Neurally Adjusted Ventilatory Assist) ventilation and conventional pressure-controlled ventilation
- What this could lead to
- If successful, this study could provide physiological evidence to support using NAVA ventilation to improve breathing mechanics in newborns with CDH, potentially reducing ventilation duration and complications.
- What could go wrong
- This is a very small pilot study with only 8 participants, so results may not apply to all newborns. It measures short-term breathing effort, not long-term outcomes like survival or hospital stay.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Service de Réanimation Néonatale- Hôpital Femme Mère Enfant- Hospices Civils de Lyon
Bron, 69500, France
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