Tiny study tests smarter ventilator for babies born with diaphragm defect
NCT ID NCT03250793
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This pilot study looked at 8 newborns with congenital diaphragmatic hernia (a hole in the diaphragm) after surgery. Researchers compared two types of breathing machines: standard ventilation and a newer method called NAVA, which senses the baby's own breathing signals to provide synchronized support. The goal was to measure how hard the babies had to work to breathe with each machine, using a small pressure sensor in the esophagus. This early study aims to understand the physiology before testing if NAVA leads to better outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NAVA (Neurally Adjusted Ventilatory Assist) ventilation and conventional pressure-controlled ventilation
What this could lead to
If successful, this study could provide physiological evidence to support using NAVA ventilation to improve breathing mechanics in newborns with CDH, potentially reducing ventilation duration and complications.
What could go wrong
This is a very small pilot study with only 8 participants, so results may not apply to all newborns. It measures short-term breathing effort, not long-term outcomes like survival or hospital stay.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HERNIA, DIAPHRAGMATIC, CONGENITAL are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Service de Réanimation Néonatale- Hôpital Femme Mère Enfant- Hospices Civils de Lyon
Bron, 69500, France