Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can targeted breathing exercises help ventilator patients regain diaphragm strength?

NCT ID NCT07709793

Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study investigates whether high- or low-intensity inspiratory muscle training (IMT) better improves diaphragm function in patients who have been on mechanical ventilation for over 21 days. Using ultrasound, researchers will measure changes in diaphragm movement and thickness over up to two weeks of training. The goal is to determine which intensity level may lead to successful weaning from the ventilator.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inspiratory muscle training (IMT) as a procedure
What this could lead to
If successful, this could help identify the best intensity of breathing exercises to help patients on ventilators regain diaphragm strength and breathe on their own sooner.
What could go wrong
This is a small, early-stage study with only 36 participants, so results may not apply to all patients. The training may not improve outcomes or could cause discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Mar 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Willing and able to provide written informed consent. 2. Adults aged \>20 years. 3. Patients requiring mechanical ventilation for \>21 days and admitted to the Respiratory Care Center (RCC). 4. Hemodynamically stable and not receiving vasopressor therapy. 5. Clinically stable and considered by the attending physician to be ready to begin weaning from mechanical ventilation. Ventilator settings must meet all of the following criteria: (1) Fraction of inspired oxygen (FiO₂) \< 0.60. (2) Positive end-expiratory pressure (PEEP) ≤10 cmH₂O. (3) Able to trigger spontaneous breaths on the ventilator. (4) Respiratory rate \<25 breaths/min. (5) Respiratory muscle weakness confirmed by maximal inspiratory pressure (MIP), defined as MIP \<30 cmH₂O. Exclusion Criteria: 1. Hemodynamic instability, including cardiac arrhythmia, decompensated heart failure, or acute coronary syndrome. 2. Active hemoptysis. 3. Presence of a chest tube. 4. Use of home mechanical ventilation. 5. Uncontrolled pain or dyspnea. 6. Patients determined to be ventilator-dependent and requiring long-term mechanical ventilation. 7. Patients or their legally authorized representatives who are unwilling or unable to provide written informed consent.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Diaphragm dysfunction are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

diaphragm disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prolonged mechanical ventilation

Contacts and locations

Locations

  • Linkou Gung Memorial Hospital

    Taoyuan, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.