Chang Gung Memorial Hospital

This study is testing a new drug called HCB101 combined with standard treatments for advanced or metastatic colorectal cancer. About 40 adults will receive weekly infusions to find the safest dose and see if the combination helps shrink tumors. The goal is to control the disease,…

This study tests whether adding Kremezin (AST-120) to standard care can help people with acute kidney disease recover better by lowering harmful toxins in the blood. About 100 adults aged 18-80 with moderate kidney injury will take Kremezin or a placebo for 180 days. The goal is …

This study tests a drug called DAOIB in 123 people with early-stage Alzheimer's or mild cognitive impairment. Participants take the drug for 24 weeks, and researchers check their thinking skills and blood markers every 8 weeks. The goal is to see if DAOIB can slow down memory los…

This early-phase study tests whether fecal microbiota transplantation (FMT) can improve both gastrointestinal and autism-related symptoms in 60 people aged 7–30 with autism and gut issues. FMT aims to restore healthy gut bacteria, which may reduce digestive discomfort, autistic b…

This study tests whether a phenylalanine-free diet can safely lower high blood phenylalanine levels in critically ill adults in the intensive care unit. High phenylalanine is linked to serious problems like brain dysfunction and metabolic issues. The trial will enroll 100 patient…

This study tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy and radiation can help women with a rare, aggressive cervical cancer live longer without the disease getting worse. About 45 women with previously untreated cancer will receive the combina…

This study tests a new treatment for people with advanced liver cancer that cannot be removed by surgery. It combines precise proton radiation with two immunotherapy drugs (tremelimumab and durvalumab) to boost the immune system's attack on tumors. About 45 participants will rece…

This study tests whether combining a statin with ezetimibe works better than a statin alone to lower LDL cholesterol below 70 mg/dL in people who recently had a stroke. About 300 adults with evidence of artery hardening and high cholesterol will be randomly assigned to one of the…

This study tests whether adding proton radiation to standard immunotherapy (atezolizumab and bevacizumab) can improve outcomes for people with liver cancer that cannot be removed by surgery. About 45 participants will receive the combination therapy. The goal is to see if this ap…

This study tests a new rehabilitation program that combines robot-assisted hand and arm training with task-oriented exercises in a circuit format. The goal is to improve motor control, daily function, and quality of life in 87 adults who have had a stroke at least three months ag…

This study looks at whether a multimedia education program (like videos and interactive materials) can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to receive either standard instructions or the multi…

This study tests whether virtual reality (VR) and mixed reality (MR) games can help people who had a stroke move their arms and hands better. 45 adults aged 20 to 80 with arm weakness will try these high-tech mirror therapy systems or standard therapy. The goal is to see if the g…

This study tests if laser acupuncture can reduce shoulder pain and improve movement in people who have had a stroke. About 58 adults with shoulder pain starting 7 days to 6 months after their stroke will receive the treatment. The goal is to see if this needle-free approach helps…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) on the right inferior frontal gyrus in 60 people with autism aged 8 to 30. The goal is to see if it can improve social skills, reduce repetitive behaviors, and help with emotional con…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study tests whether adding an antioxidant to an NMDA-enhancing drug can improve thinking and memory more than the NMDA drug alone. It involves 80 people with early Alzheimer's or mild cognitive impairment. Participants will be followed for 24 weeks to see changes in cognitiv…

This study tests a cushion called DaSuit® to see if it can reduce discomfort from sitting in adults with non-specific low back pain. Twenty participants will sit on either the DaSuit® or a placebo cushion for 10 minutes, then switch. Researchers will measure pressure under the bu…

This study compares two surgical techniques for repairing a torn ACL, the main knee ligament. Forty adults with ACL injuries will be randomly assigned to one of two procedures. Researchers will measure knee stability, function, and re-tear rates over one year to see which method …

This study tests whether an injection made from amniotic tissue can reduce pain and improve knee function in people with knee osteoarthritis. About 160 adults with moderate knee arthritis will receive either the amniotic injection, a standard hyaluronic acid injection, or a place…

This study tests if watching online interactive videos can improve bowel symptoms, emotional distress, and quality of life in people who have had rectal cancer. About 110 adults with stage I-III rectal cancer will participate. The videos are designed to teach coping strategies fo…

This study tests a drug called DAOIB to see if it can help with memory and thinking problems caused by long COVID. About 40 adults with long COVID and brain fog will take the drug for 24 weeks. Researchers will check their thinking skills, mood, and quality of life every 8 weeks.

This study explores whether artificial intelligence can estimate a person's cognitive test scores by analyzing a short speech recording. 150 adults aged 50 and older will tell a story based on a picture while their voice is recorded. The AI's predictions will be compared to stand…

This study creates and tests a training course for Care Food Specialists in Taiwan to help long-term care workers better support eating and oral health. About 150 healthy students in care programs will take the course and be assessed before and after. The goal is to improve their…

This study looks at whether a simple blood test that finds leftover cancer cells (circulating tumor cells) can help doctors decide which oral cancer patients need extra chemotherapy after standard treatment. About 100 adults with high-risk oral cancer will be tested after finishi…

This study is developing and testing an AI program called AIFIGA to help families and nursing home staff communicate better. Researchers will first gather input from families and staff to build the AI, then test it with 210 residents, families, and staff over 6 months. The goal i…

This study looks at tiny molecules called microRNA and tumor cells floating in the blood of 300 cancer patients before and after they receive immunotherapy. The goal is to see how these markers change with treatment. This is an observational study that does not offer a new treatm…

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will compare healthy young, middle-aged, and older adults, as well as people with Parkinson's disease. The goal is to understand which muscle factors …

This study is looking for a better way to predict if immunotherapy will help people with head and neck cancer. Currently, doctors use a tissue sample, but that can't be easily repeated. Researchers will test a simple blood test that looks at cancer cells and immune markers to see…

This study compares newer laser techniques for cataract or nearsightedness surgery to see which one reduces inflammation and helps eyes heal better. Researchers will measure natural antioxidants in tears and eye fluid before and after surgery in 1000 adults. The goal is to find o…

This study looks at why cancer patients have a higher risk of blood clots. Researchers will compare blood samples from 120 people with and without cancer who need a clot-removal procedure. They aim to understand how tumor cells and certain treatments affect clot formation, which …

This study looks at head and neck cancer patients who have had radiation therapy to see how often they develop blood vessel narrowing or brain problems. Researchers will follow 800 patients using brain scans and ultrasound. The goal is to better understand these complications, no…

This study aims to find out if certain substances in the body (called metabolites) can predict how well rectal cancer responds to chemotherapy and radiation before surgery, and whether severe side effects like radiation proctitis will occur. Researchers will collect blood, urine,…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 adults with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help design personalized prevention or treatment strategies. Part…

This study looks at how getting older and having tired muscles change the way people balance and walk. Researchers will test 140 adults, both young (20-40) and older (60-85), by having them do exercises that tire out their arms or legs. The goal is to better understand these effe…

This study is creating a video and audio library to help teach occupational therapy skills. Researchers will record real therapy sessions and training activities with permission from therapists, trainees, and patients. The goal is to improve how clinical skills are taught and ass…