Chang Gung Memorial Hospital

This study is for people with metastatic pancreatic cancer that has spread. It tests a new combination of three drugs (S-1, nab-paclitaxel, and gemcitabine) to find the safest and most effective dose. About 70 participants will take part to see how well the treatment shrinks tumo…

This study tests whether fecal microbiota transplantation (FMT) can help people with severe gut graft-versus-host disease (GvHD) that doesn't respond to steroids. GvHD is a common and dangerous complication after stem cell transplants, where donor cells attack the patient's body.…

This study tests whether fecal microbiota transplantation (FMT) can help children and young adults with autism who also have stomach issues. FMT involves transferring healthy donor stool into the patient's gut via colonoscopy. Researchers will track changes in gut and autism symp…

This phase 2 trial is testing whether adding proton radiotherapy to standard immunotherapy (atezolizumab and bevacizumab) can better control advanced liver cancer that cannot be removed by surgery. About 45 participants will receive the combination treatment. The study will measu…

This study tests whether a phenylalanine-free diet, similar to that used for a rare genetic condition, can safely lower high blood phenylalanine levels in critically ill adults in the ICU. High phenylalanine in these patients is linked to a higher risk of death and brain problems…

This Phase 2 trial tests whether adding an antioxidant to an NMDA-enhancing drug (DAOIB) improves thinking and memory more than the drug alone in people with early Alzheimer's or mild cognitive impairment. Eighty participants will take the combination or a placebo for 24 weeks. R…

This phase 2 trial is testing a drug called DAOIB in 123 people with mild Alzheimer's disease or mild cognitive impairment. Participants take DAOIB for 24 weeks, with dose adjustments every 8 weeks. Researchers will measure changes in thinking and memory, and look at blood marker…

This Phase 3 trial tests whether injections of amniotic suspension allograft (ASA) can reduce pain and improve function in people with knee osteoarthritis. 160 participants will receive either ASA, hyaluronic acid, or a saline placebo. Researchers will track pain, knee function, …

This study is testing whether adding the immunotherapy drug dostarlimab to standard chemotherapy and radiation can help women with a rare and aggressive type of cervical cancer called small cell neuroendocrine carcinoma. About 45 women with early to advanced stages of the disease…

This study tests whether combining a statin with ezetimibe (another cholesterol-lowering drug) works better than a statin alone in people who recently had a stroke. Researchers will enroll 300 adults aged 20 or older who had a stroke or TIA within the past 30 days and have high L…

This early-stage trial tests an experimental drug called HCB101 alongside standard treatments (bevacizumab, cetuximab, and chemotherapy) in 40 people with advanced or metastatic colorectal cancer. The goal is to see if the combination is safe and shows signs of shrinking tumors. …

This study compares two surgical methods for repairing a torn ACL, the main knee ligament. Forty adults who need ACL surgery will be randomly assigned to receive either a single-bundle or double-bundle reconstruction, both combined with an extra ligament repair. Researchers will …

This study tests whether Kremezin (AST-120), a pill that absorbs toxins in the gut, can help kidneys recover after acute injury. Researchers will give 100 adults with acute kidney disease either Kremezin plus standard care or standard care alone for 14 days. They will measure tox…

This phase 2 trial tests a new combination treatment for people with advanced liver cancer that cannot be removed by surgery. It combines precise proton radiation with two immunotherapy drugs, tremelimumab and durvalumab. The goal is to see if this approach is safe and works bett…

This study tests whether artificial intelligence can predict cognitive test scores by analyzing how people tell a story. 150 adults aged 50 and older will describe a picture while their speech is recorded. The AI will look for patterns in voice and language, and researchers will …

This study tests whether combining a non-invasive brain stimulation technique (rTMS) with machine-assisted hand exercises can help stroke survivors regain arm and hand movement. Researchers will enroll 54 adults aged 40-80 who had a first stroke within the past year. Participants…

This study tests whether a brief mindfulness or biofeedback session before shoulder surgery can reduce pain, improve shoulder function, sleep, mood, and quality of life after the operation. About 120 people with long-term shoulder pain will be randomly assigned to one of three sh…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can improve core symptoms of autism, such as social difficulties and repetitive behaviors. Researchers will apply TBS to a specific brain area (right inferior frontal gyrus) i…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study tests whether online interactive videos that guide core muscle exercises can improve bowel symptoms, psychological distress, and quality of life in people who have had rectal cancer surgery. About 110 adults with stage I-III rectal cancer will be assigned to either a g…

This study tests a new rehabilitation program for people who have had a stroke. It combines robot-assisted hand and arm training with task-oriented therapy in a circuit training format. The goal is to improve arm movement, daily activities, and quality of life. The study will inc…

This study tests two new therapy systems that use virtual reality (VR) or mixed reality (MR) to help stroke survivors improve arm function. Participants will perform movements while watching a mirrored hand in a headset. The trial aims to see if these high-tech approaches are fea…

This study tests a drug called DAOIB in 40 people with Long COVID who have memory and thinking problems (brain fog). Everyone gets the drug for 24 weeks, and researchers check their thinking skills, mood, and quality of life every 8 weeks. The goal is to see if DAOIB can help imp…

This study tests whether laser acupuncture can reduce shoulder pain and improve movement in people who recently had a stroke. Researchers will compare real laser acupuncture to a sham (fake) version in 58 adults. The goal is to see if this needle-free approach offers a safe, drug…

This study tests a new AI program designed to improve communication between nursing home residents, their families, and staff. The program uses artificial intelligence to help with conversations and support. Researchers will track changes in depression, daily living skills, and s…

This study tests whether a 10-minute educational video can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to watch the video or receive only standard instructions. Researchers will measure anxiety level…

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This study uses a brain imaging technique called fNIRS to watch how the brain changes during robot-assisted hand therapy in stroke survivors. Researchers will compare two types of robotic devices (end-effector and exoskeleton) to see which one better promotes brain reorganization…

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will compare healthy young, middle-aged, and older adults, as well as people with Parkinson's disease. The goal is to understand why falls happen more…

This study is collecting blood, urine, tissue, and stool samples from 250 people with locally advanced rectal cancer who are about to receive chemotherapy and radiation before surgery. Researchers will analyze these samples for tiny substances called metabolites to see if they ca…

This study is creating a library of video and audio recordings to help teach occupational therapy skills. Researchers will record real therapy sessions, skill demonstrations, and practice with patients and trainees. About 2,020 occupational therapists, interns, and adult patients…

This study follows 800 head and neck cancer patients who have had radiation therapy to see how often they develop blood vessel narrowing, strokes, or brain changes. Researchers will compare patients with nasopharyngeal cancer to those with other head and neck cancers. The goal is…

This study looks at how getting older and muscle tiredness affect a person's ability to stand steady and walk. Researchers will measure balance, walking speed, and muscle strength in 140 healthy adults (young and old) after they do exercises that tire out their arms or legs. The …

This study is testing whether a simple blood test can predict how well immunotherapy works in people with head and neck cancer. Researchers will measure a protein called PD-L1 on tumor cells that have escaped into the bloodstream. The goal is to see if these 'liquid biopsies' can…

This study tests a 20-hour training course designed to improve how healthcare aides help elderly people eat safely. Researchers will enroll 150 students in long-term care programs in Taiwan and measure changes in their knowledge, attitudes, and behaviors before and after the trai…

This study looks at whether a blood test that finds circulating tumor cells (CTCs) can help decide if oral cancer patients need extra chemotherapy after standard treatment. About 100 patients who have completed surgery and chemoradiotherapy will be tested. If their CTC count is h…

This study is looking at tiny particles in the blood called microRNA and circulating tumor cells in 300 cancer patients who are about to start immunotherapy. By comparing blood samples taken before and after treatment, researchers hope to see how these markers change. The goal is…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help create personalized prevention and treatment plans. Particip…

This study looks at why cancer patients have a much higher risk of developing blood clots. Researchers will collect blood clots from 120 patients (with and without cancer) who undergo a procedure to remove clots. They will analyze the clots for cancer cells and other factors to b…

This study will compare different laser techniques used in eye surgeries for cataracts and myopia. Researchers want to see which method causes less inflammation and oxidative stress, and leads to better vision recovery. 1,000 patients will be followed for three months after surge…