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Blood test may replace biopsies for immunotherapy monitoring

NCT ID NCT07396259

Recruiting now Knowledge-focused Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a simple blood test can predict how well immunotherapy works in people with head and neck cancer. Researchers will measure a protein called PD-L1 on tumor cells that have escaped into the bloodstream. The goal is to see if these 'liquid biopsies' can replace repeated tissue biopsies and help doctors adjust treatment more quickly. The study involves 150 participants and is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
liquid biopsy (blood test for circulating tumor cells)
What this could lead to
If successful, this could lead to a simple blood test that helps doctors decide if immunotherapy is working, without needing repeated tissue biopsies.
What could go wrong
This is an early-stage observational study, not a treatment trial. The blood test may not reliably predict outcomes, and results may not change current care for years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms Neoplastic Cells, Circulating

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRCULATING TUMOR CELLS (CTCS) IMMUNOTHERAPY LIQUIDBIOPSIES PD-L1 EXPRESSION

Contacts and locations

Locations

  • Linkou Chang Gung Memorial Hospital

    RECRUITING

    Taoyuan, City, 333, Taiwan

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