Blood test may tell which oral cancer patients need more chemo

NCT ID NCT07296250

Recruiting now Knowledge-focused Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a blood test that finds circulating tumor cells (CTCs) can help decide if oral cancer patients need extra chemotherapy after standard treatment. About 100 patients who have completed surgery and chemoradiotherapy will be tested. If their CTC count is high, they will receive low-dose oral chemotherapy for up to a year. The goal is to see if this approach improves survival and creates a new standard for monitoring the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-dose oral chemotherapy
What this could lead to: If successful, this could provide a standard way to detect remaining cancer cells in the blood and guide personalized chemotherapy, potentially improving survival for oral cancer patients.
What could go wrong: This is a small, early-phase trial with only 100 participants. The approach is experimental, and it is not yet known if using CTC counts to guide treatment truly improves outcomes or causes side effects.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms lip and oral cavity carcinoma Mouth Neoplasms Neoplastic Cells, Circulating oral cavity squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER ORAL CANCER

Contacts and locations

Locations

Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan City, 333423, Taiwan

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