ORAL CANCER

This study tests whether using ultrasound during oral cancer surgery helps surgeons remove tumors more completely. About 150 adults with early-stage oral cancer will be randomly assigned to standard surgery or surgery guided by real-time ultrasound. The goal is to see if ultrasou…

This study tests whether giving antibiotics before surgery can lower the amount of bacteria found inside oral cancer tumors. About 30 adults with oral cancer will receive metronidazole and a special mouthwash before their planned surgery. Researchers will compare bacteria levels …

This study compares two non-invasive methods—a mouth cell brush test and a special microscope—to see if they can accurately detect precancerous and early cancerous spots in the mouth. Researchers will enroll 400 adults with visible mouth lesions. If successful, these tools could …

This study tests whether an AI-powered physiotherapy app can help oral cancer patients regain jaw movement, shoulder function, and overall physical ability after surgery, chemo, or radiation. One hundred adults aged 20-65 will be split into two groups: one using the AI app for 12…

This study tests whether starting tongue strengthening exercises soon after tongue cancer surgery can improve speech and swallowing. About 40 adults who have part of their tongue removed will use a biofeedback device called the Tongueometer to guide their exercises. The goal is t…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether a custom dental device called a palatal augmentation prosthesis (PAP) can improve speech and swallowing after surgery for small tongue cancers (T1/T2). About 40 adults will be randomly assigned to receive the device or standard care. Researchers will meas…

This study tests two different painkiller combinations (dezocine vs. nalbuphine, both with sufentanil) in 60 adults undergoing oral cancer surgery with flap reconstruction. The goal is to find which provides better pain control, fewer side effects like nausea, and helps the surgi…

This study is testing a smartphone app powered by artificial intelligence to help people with oral cancer return to work and manage physical and emotional challenges. Researchers will compare 650 patients who use the app with those who receive standard care. The goal is to see if…

This study follows oral cancer patients who completed a previous rehabilitation trial. It compares AI-based physiotherapy to standard physiotherapy to see which better improves jaw movement, shoulder function, overall physical health, quality of life, and return to work. Research…

This study looks at whether a simple blood test that finds leftover cancer cells (circulating tumor cells) can help doctors decide which oral cancer patients need extra chemotherapy after standard treatment. About 100 adults with high-risk oral cancer will be tested after finishi…

This study aims to understand why oral cancer hurts by comparing pain sensitivity between 40 oral cancer patients and 40 healthy volunteers. Researchers will measure how much pressure and tongue stretching causes pain. The goal is to learn more about the role of certain nerve cel…

This study tests whether an AI-powered chatbot can teach African American adults about oral cancer better than a standard educational handout. About 60 participants will use either the chatbot or the handout, then take surveys to measure their knowledge, attitudes, and satisfacti…

This study is testing whether an AI system can accurately measure jaw, neck, and shoulder movement in people with and without oral cancer. Researchers will compare the AI's measurements to standard methods. The goal is to develop a simpler way to track movement problems caused by…

This study looks at whether changes in the natural bacteria living in your mouth and gut (the microbiome) play a role in head and neck cancer. Researchers will collect stool and saliva samples from 60 adults—some with cancer and some without—to compare their microbiomes. The goal…

This study is collecting tissue samples and symptom reports from 1,000 people with oral cancer or pre-cancer. Researchers want to find biological markers that can predict how the disease will behave and how well a patient will respond to treatments like surgery, chemo, or immunot…

This study checks if an AI-based system can accurately measure how well people can move their jaw, neck, and shoulders. Twenty healthy adults will perform simple movements while the AI and two human raters take measurements. The goal is to see if the AI is as reliable as traditio…