Diaphragm disorder
MONDO:0005728A disease involving the diaphragm.
Also known as: diaphragm disease, diaphragm disease or disorder, disease of diaphragm, disease or disorder of diaphragm, disorder of diaphragm, diaphragmatic disease, diaphragmatic disorder
117 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Fish oil infusion may ease lung pressure in fragile newborns
Disease control ENROLLING_BY_INVITATIONThis study tests whether a special fish-oil emulsion given through an IV can improve outcomes for newborns with a diaphragm defect that causes severe lung pressure. About 40 babies will receive either the fish-oil emulsion or a standard soy-oil one. Researchers will measure lung …
Phase: PHASE2 • Sponsor: Coordinación de Investigación en Salud, Mexico • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Balloon in the womb could save babies with rare birth defect
Disease control OngoingThis study tests a procedure called FETO, where a tiny balloon is placed in the windpipe of unborn babies with severe congenital diaphragmatic hernia (CDH). The balloon helps the lungs grow before birth and is later removed. Researchers want to see if this improves survival and r…
Phase: NA • Sponsor: Inna Lobeck • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Rare hernia surgery in older kids: what works best?
Disease control OngoingThis study looks at how children aged 1 month to 15 years with a late-diagnosed congenital diaphragmatic hernia (a hole in the muscle that separates the chest from the belly) do after surgery. Researchers reviewed 10 cases treated at one hospital with either keyhole or open surge…
Phase: NA • Sponsor: Jehad Emam Abdelrahman • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Balloon in the womb: new hope for babies with underdeveloped lungs?
Disease control OngoingThis pilot study tests a procedure called FETO in 14 unborn babies with severe left congenital diaphragmatic hernia (CDH), a birth defect where abdominal organs push into the chest and stunt lung growth. Doctors place a tiny balloon in the baby's windpipe via fetoscopy to trap lu…
Phase: NA • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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In-Womb balloon procedure could save babies with rare birth defect
Disease control OngoingThis study tests a procedure called FETO, where a tiny balloon is placed in the windpipe of a fetus with severe left congenital diaphragmatic hernia (CDH). The balloon blocks fluid from leaving the lungs, causing them to grow larger before birth. The goal is to improve survival f…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Timing of cord clamp could save lungs in rare birth defect
Disease control OngoingThis study tests whether waiting to clamp the umbilical cord until after the baby's lungs have filled with air can reduce dangerous lung blood pressure (pulmonary hypertension) in newborns with congenital diaphragmatic hernia (CDH). About 140 infants with left-sided CDH will be r…
Phase: NA • Sponsor: Erasmus Medical Center • Aim: Disease control
Last updated Jun 26, 2026 17:00 UTC
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Can a new breathing workout help lung transplant patients breathe easier?
Disease control ENROLLING_BY_INVITATIONThis study compares two types of breathing muscle training in people who have had a lung transplant. One group does standard constant-resistance exercises, while the other adds short bursts of harder effort. The goal is to see which method better improves breathing strength and d…
Phase: NA • Sponsor: Hospital Universitario Marqués de Valdecilla • Aim: Disease control
Last updated Jun 26, 2026 14:58 UTC
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Fetal lung MRI hopes to spot breathing trouble before birth
Diagnosis TerminatedThis study was designed to see if a special MRI technique (BOLD) could measure how well fetal lungs work in babies with diaphragmatic hernia or abdominal wall defects. Researchers planned to scan the lungs while the mother breathed normal air and then oxygen, looking for changes …
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Jun 27, 2026 11:01 UTC
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New program aims to ease burden on families of kids with rare diseases
Symptom relief ENROLLING_BY_INVITATIONThis study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …
Phase: NA • Sponsor: Children's National Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Weekly Check-Ins could boost patient satisfaction for chronic pain
Knowledge-focused TerminatedThis study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…
Phase: NA • Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Can a special clinic get workers back on the job faster? norway launches massive study.
Knowledge-focused OngoingThis study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…
Phase: NA • Sponsor: Nordlandssykehuset HF • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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New pilot study tests In-Utero treatment for rare birth defect
Knowledge-focused TerminatedThis pilot study aims to learn more about a procedure called FETO for unborn babies with a severe form of congenital diaphragmatic hernia (CDH). The researchers want to see if placing a balloon in the baby's windpipe before birth can help the lungs grow and improve survival. The …
Phase: NA • Sponsor: Eyal Krispin • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Massive PT study mines 4 million records to find what works best
Knowledge-focused OngoingThis study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …
Sponsor: ATI Holdings, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Phone app vs. doctor: can a mobile tool catch infections after surgery?
Knowledge-focused TerminatedThis study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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New breath test could replace painful lung scopes
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…
Phase: PHASE2 • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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3D imaging could offer new way to diagnose diaphragm dysfunction
Knowledge-focused OngoingThis study tests a new 3D imaging method to measure how much air the lungs can hold in people with suspected diaphragm weakness. About 100 adults will have two quick 3D scans while holding their breath. The goal is to see if this technique gives reliable results compared to stand…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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New study aims to spot hidden breathing muscle damage from heart procedure
Knowledge-focused TerminatedThis study looks at a possible side effect of a heart treatment called PFA for atrial fibrillation: injury to the phrenic nerve, which can paralyze part of the diaphragm and affect breathing. Patients get a special X-ray before and after the procedure to check diaphragm movement.…
Sponsor: Laurent Macle • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC