Timing of cord clamp could save lungs in rare birth defect
NCT ID NCT04373902
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether waiting to clamp the umbilical cord until after the baby's lungs have filled with air can reduce dangerous lung blood pressure (pulmonary hypertension) in newborns with congenital diaphragmatic hernia (CDH). About 140 infants with left-sided CDH will be randomly assigned to either immediate cord clamping or delayed clamping using a special trolley. The goal is to see if this simple timing change lowers the chance of severe lung problems in the first day of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Physiological-based cord clamping (PBCC) procedure
What this could lead to
If it works, this simple change in how the umbilical cord is clamped could lower the risk of severe lung blood pressure problems in these fragile newborns.
What could go wrong
This is a relatively small, early-stage trial (140 infants). The procedure requires special equipment and may not be feasible in all delivery settings. Benefits seen in animal models may not translate to humans.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Erasmus MC University Medical Center - Sophia Children's Hospital
Rotterdam, Netherlands
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Karolinska University Hospital
Stockholm, Sweden
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Medical University Graz
Graz, Austria
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Monash University
Melbourne, Australia
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Ospedale Pediatrico Bambino Gesu
Rome, Italy
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Radboudumc University Medical Center
Nijmegen, Netherlands
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University Hospitals leuven
Leuven, Belgium
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Universitätsklinik Mannheim
Mannheim, Germany
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Universitätskrankenhaus Bonn
Bonn, Germany