PULMONARY HYPERTENSION

This study tests an inhaled powder called treprostinil palmitil for people with high blood pressure in the lungs caused by scarring lung disease. About 344 adults will receive either the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them wal…

This study tests a procedure called FETO (fetal endoscopic tracheal occlusion) in pregnant women whose babies have a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm is missing or has a hole, causing the lungs to be underdeveloped. The procedure temporari…

This study looks at whether different oxygen levels can help preterm infants who have both a chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in the lungs (pulmonary hypertension). About 39 infants born extremely early will be enrolled. Researchers will m…

This study tests an experimental drug called TX000045 in people who have high blood pressure in the lungs caused by a specific type of heart failure (HFpEF). About 180 adults will receive either the drug or a placebo for 24 weeks to see if it improves blood flow and is safe. The …

This early study tests a new way to use a heart-lung machine (ECMO) to keep people with severe lung disease and heart failure alive until they can get a lung transplant. The approach uses a special tube placed across the heart's wall to improve blood flow. Only 4 participants wil…

This study tests whether adding empagliflozin or ranolazine to standard treatment can improve right heart function in 30 adults with pulmonary hypertension and right heart failure. Participants are randomly assigned to one of the two drugs plus usual care, or usual care alone. Th…

This study tests whether adding a new inhaled drug, mosliciguat, to an existing treatment (treprostinil) is safe for people with high blood pressure in the lungs caused by lung scarring. About 20 adults with this condition will receive the combination and be monitored for side ef…

This study looks at the long-term safety and effects of an experimental medicine called PF-07868489 for people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lung arteries makes the heart work harder. It is an open-label extension study, …

This study tests a stem cell transplant for people aged 8-24 with severe systemic sclerosis (scleroderma) that hasn't improved with standard treatments. The goal is to see if this approach is safer and still controls the disease. Participants receive high-dose therapy to reset th…

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This study tests a new device for people with pulmonary hypertension and right heart dysfunction. The device is implanted to help blood flow better in the lungs. About 30 adults will take part to see if it is safe and works well. The goal is to improve symptoms and heart function…

This study tests an oral medication called levosimendan in 230 adults with pulmonary hypertension and a type of heart failure where the heart pumps normally but is stiff. The main goal is to see if the drug helps people walk farther in six minutes compared to a placebo. Participa…

This study tests whether tadalafil, a drug that relaxes blood vessels, can improve exercise ability in people with severe high blood pressure in the lungs caused by COPD. About 200 adults will receive either tadalafil or a placebo pill for 16 weeks. The main goal is to see if tho…

This study tests a remote monitoring system to better manage oxygen therapy in premature infants born before 32 weeks who have bronchopulmonary dysplasia (a chronic lung disease). The goal is to reduce health complications and improve development by closely tracking oxygen needs.…

This study tests whether sildenafil (a drug often used for erectile dysfunction) can help people with severe high blood pressure in the lungs caused by rheumatic heart valve disease. About 100 adults will receive either sildenafil or a placebo for six weeks. The goal is to see if…

This study aims to see if voice recordings can help detect pulmonary hypertension, a serious heart and lung condition. Researchers will compare voice patterns with standard echocardiogram results in 7,000 adults. If successful, this could lead to a simple, non-invasive screening …

This study is testing whether a non-invasive, radiation-free chest scan called electrical impedance tomography (EIT) can accurately diagnose pulmonary hypertension, a serious lung and heart condition. Currently, diagnosis requires an invasive procedure called right heart catheter…

This study tests whether an artificial intelligence (AI) tool can analyze a simple ECG to detect undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be randomly assigned to…

This study is testing whether a special digital stethoscope, which also records a single-lead ECG, can help doctors spot pulmonary hypertension (high blood pressure in the lungs) earlier. Researchers will collect heart and lung sounds from over 2,400 adults who are already schedu…

This early-stage study tests whether an oral supplement called L-Citrulline is safe for preterm infants born at or before 30 weeks who have lung disease (BPD), sometimes with high blood pressure in the lungs (PH), or a serious gut condition (NEC). The goal is to see if raising lo…

This study tests whether long-term rehabilitation training can improve heart and lung function in people with pulmonary arterial hypertension (PAH). About 104 adults with stable PAH will be randomly assigned to either a rehab program or standard care. Researchers will measure wal…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study tests whether a 16-week home exercise program, guided by a smartwatch, can help children aged 8-18 with pulmonary hypertension become more active and improve their muscle strength and quality of life. Participants will wear activity trackers and follow a personalized e…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and obesity, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks while researchers monitor side…

This study tests whether giving iron through a vein can improve exercise ability and daily function in people with pulmonary hypertension (high blood pressure in the lungs) who also have low iron levels. Many patients with this condition have iron deficiency that oral supplements…

This study is an observational registry that will follow about 120 adults with pulmonary hypertension who are being treated with the drug sotatercept. Researchers will track quality of life, hospitalizations, medication changes, and side effects to understand how the drug works i…

This study is a registry that collects information from children and teens under 18 who have pulmonary hypertension, a rare lung condition. Researchers will follow these patients over time to see how the disease progresses, how well treatments work, and what their long-term healt…

This study tests a new ultrasound technology that can continuously monitor blood flow in the brains of sick and premature infants. Researchers will enroll 180 babies, including healthy preterm and term infants as well as those with conditions like heart defects, infections, or st…

This study is testing a new device called HemoCept during a routine heart procedure (right heart catheterization). The goal is to see if the device can accurately measure pressure in the heart's blood vessels. About 50 adults with conditions like pulmonary hypertension or heart f…

This study is testing a new risk score called PVD-B65 to see if it can accurately predict who will survive for one year after being diagnosed with pulmonary hypertension related to chronic lung disease. Researchers will follow 100 adults and track their health outcomes. The goal …

This study is creating a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health over time. No trea…

This study looks at how the right side of the heart works during rest and exercise in people with COPD. Researchers want to find different patterns of heart strain to guide future treatments. About 60 adults aged 40 and older with COPD will take part. The goal is to better unders…

This study is testing a new type of MRI that uses a special gas (xenon) to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this imaging method can b…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study is testing whether advanced PET/MR scans and blood tests can spot early signs of heart and lung damage caused by radiation therapy for chest cancers. About 40 adults who will receive chest radiation will be followed with imaging and blood draws before and after treatme…

This study tests whether artificial intelligence (AI) can help doctors find a serious lung condition called pulmonary arterial hypertension (PAH) earlier in people with systemic sclerosis (scleroderma). Researchers will compare AI-based screening to traditional methods in 350 adu…

This study looks at why people with pulmonary arterial hypertension (PAH) lose muscle and become less active. Researchers will measure body composition, heart fat, and daily activity in 150 adults with PAH. The goal is to find factors that could be treated to improve quality of l…

This study compares noninvasive heart ultrasound (echocardiogram) with the standard invasive right heart catheterization in 3,000 people with suspected pulmonary hypertension or left heart disease. The goal is to see if ultrasound can accurately measure heart function and blood f…

This study tests whether a special type of MRI, using inhaled xenon gas, can show how well the drug sotatercept is working in people with pulmonary arterial hypertension (PAH). PAH is a serious condition where blood vessels in the lungs narrow, making the heart work harder. The s…

This study looks back at medical records of 1000 adults with COPD who had a special heart test. The goal is to learn more about a condition called pulmonary hypertension, where blood vessels in the lungs are under high pressure. By analyzing past data, researchers hope to better …

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart dysfunction that could lead to better treatments. The study involves 60 adults aged 40 and older with CO…

This study looks at how genes influence the risk of pulmonary hypertension, a serious lung condition. Researchers aim to enroll 10,000 adults in the US, with or without the disease. Participants complete online health surveys and provide a saliva sample by mail. The goal is to fi…

This study will follow at least 700 people with pulmonary hypertension (high blood pressure in the lungs) for several years. Every 6 months, a computer system checks in with patients to record any side effects from their medications and track deaths. The goal is to better underst…

This study tests whether nicotinamide riboside, a form of vitamin B3, affects certain biological markers in people with combined pulmonary hypertension (CPH), a serious heart and lung condition with no approved treatments. Ten participants will receive both the supplement and a p…

This study is for people on long-term dialysis who may also have high blood pressure in their lungs (pulmonary hypertension). Researchers want to find out how common this condition is, what causes it, and how it affects patients over time. About 70 adults will get heart ultrasoun…

This study is a patient registry that will collect information from 900 adults with both pulmonary hypertension (high blood pressure in the lungs) and interstitial lung disease (scarring of the lungs). The goal is to better understand the patients' health history and how their co…

This study is a large national registry that collects information from 3,000 people with pulmonary hypertension (high blood pressure in the lungs) at specialized centers across the U.S. Researchers track how patients are diagnosed, what treatments they receive, and how their heal…

This early-stage study tests a new medicine called F230 in 136 healthy adults to see if it is safe and how the body processes it. The drug is designed to treat pulmonary hypertension, a serious lung condition. Researchers will also check if food changes how the drug works. No dir…

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track participants' health, treatments, and outcomes over time to better understand these conditions. The goal is to imp…

This study checks how well a smartwatch measures oxygen levels in 20 adults with pulmonary hypertension. Researchers compare smartwatch readings to a finger clip and a blood test at rest, after exercise, and while breathing low oxygen. The goal is to see if smartwatches are relia…

This study involves 100 people with pulmonary hypertension who are already scheduled for a right heart catheterization. During the procedure, doctors will take two small blood samples from a special position in the lung artery to analyze oxygen and carbon dioxide levels. The goal…

This study looks at why the right side of the heart fails in people with a common type of heart failure (reduced pumping ability). Researchers will check which medical tests best detect right heart muscle problems and test new treatments on heart tissue samples. About 50 adults w…

This study is creating a large database of information from 900 people who have pulmonary hypertension (high blood pressure in the lungs) or are at risk for it. Researchers will collect medical history, test results, and follow-up data over time. The goal is to better understand …

This study follows people with pulmonary arterial hypertension (PAH) over several years to learn how the disease changes and to find new markers that could lead to better treatments. About 270 adults with PAH and healthy volunteers will have regular tests like blood draws, heart …

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. Participants will do walking and sitting tests to measure br…

This study is creating and testing a questionnaire to see how much people with pulmonary arterial hypertension (PAH) know about their condition. Researchers will check if the questions make sense to patients and experts. Up to 200 adults with PAH will take part. The goal is to ha…