PULMONARY HYPERTENSION

This study looks at whether the drug sotatercept can help repair damaged blood vessels in the lungs of people with pulmonary arterial hypertension (PAH). Researchers will use special imaging techniques to see if the arteries become healthier over 9 months. The study involves 30 a…

This study tests whether inhaled nitric oxide can help newborns with a hole in their diaphragm (congenital diaphragmatic hernia) who also have high blood pressure in their lungs. About 40 babies will receive the gas, and doctors will check if their oxygen levels improve. The goal…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs of people with heart failure. The treatment aims to reduce serious heart events like hospitalizations or death. About 750 adults with stable heart failure will be randomly assigned…

This study looks at the long-term safety of an inhaled drug called treprostinil palmitil (TPIP) for people with pulmonary hypertension linked to interstitial lung disease. About 344 adults who finished a previous study will take the drug and be monitored for side effects and brea…

This study tests whether the experimental drug telaglenastat can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension (PH). About 28 people with mild to moderate symptoms (classes II-III) will receive the drug on top o…

This study tests whether using ultrasound (sound waves) to guide a thin tube into the heart's blood vessels works as well as the usual X-ray method in people with pulmonary hypertension. The goal is to make the procedure safer, faster, and available at the bedside without radiati…

This study looks at whether a simple home exercise program can improve daily function in people with pulmonary hypertension caused by interstitial lung disease. About 30 adults will follow a 16-week exercise plan from home. Researchers will measure how efficiently the heart works…

This study will follow 400 people receiving stem cell transplants for blood cancers to better understand why some develop serious heart problems. Researchers will use heart scans, blood tests, and other monitoring to find early warning signs. The goal is to improve follow-up care…

This study will collect heart sound and ECG recordings from 1,000 adults undergoing routine echocardiograms. The goal is to see if artificial intelligence can accurately detect pulmonary hypertension and other heart conditions from these recordings. If successful, this could lead…

This study is testing a smartphone app called MedlyPeds that lets children with heart disease and their families report symptoms and health data from home. About 30 kids aged 8-18 will use the app for 3 months. The goal is to see if the app is easy to use and helpful, and to get …

This study will observe 55 adults with obstructive sleep apnea to see if the severity of their breathing pauses during sleep is linked to higher blood pressure in the lungs. Participants will have their sleep and heart function measured, but no new treatments are tested. The goal…

This study will use artificial intelligence and 3D ultrasound to measure how well the heart's right chambers work together in healthy adults and people with heart conditions. Researchers aim to set a normal range for this measurement and see if it can help diagnose or predict pro…

This study will follow 200 adults with pulmonary arterial hypertension who are hospitalized for sudden worsening of right heart failure. Researchers across Europe will collect medical data to see how many patients survive or need a lung transplant within 3 months. The goal is to …

This study looks at why some people with chronic lung disease develop pulmonary hypertension (high blood pressure in the lungs). Researchers will study lung tissue, blood, and fluid samples from 105 adults having lung surgery. The goal is to find early signs and possible targets …

This study will follow 300 adults who have both an abnormal connection between their liver and blood vessels (portosystemic shunt) and high blood pressure in the lungs (pulmonary hypertension). The goal is to learn more about how common this condition is, what symptoms people hav…