PULMONARY HYPERTENSION

This study aims to find the best oxygen level for premature babies who have developed a severe chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in their lungs (pulmonary hypertension). Doctors will test two different oxygen level targets in 39 infants to …

This study is testing the safety of a new inhaled drug, mosliciguat, when added to an existing inhaled medication (treprostinil) for people with pulmonary hypertension caused by scarred lungs (interstitial lung disease). It will enroll about 20 participants who are already using …

This study is testing whether a new once-daily inhaled powder (TPIP) can help adults who have pulmonary hypertension caused by scarred lungs (interstitial lung disease). Over 300 participants will use either the real powder or a placebo for 24 weeks to see if it improves how far …

This study is testing if adding the drug sildenafil (commonly known as Viagra) to standard care can help patients with severe lung pressure caused by damaged heart valves from rheumatic fever. The goal is to see if it improves how far patients can walk and their heart function wh…

This small, early-stage study is testing whether a specialized heart-lung bypass machine can safely keep critically ill patients with severe pulmonary hypertension and heart failure alive long enough to receive a lung transplant. The device is inserted through a vein and is desig…

This study is testing a fetal surgery called FETO to see if it helps babies with a severe form of congenital diaphragmatic hernia (CDH) survive and be healthier. It compares the surgery to standard prenatal care. The goal is to help babies with underdeveloped lungs and a liver in…

This nationwide study aims to monitor the safety of targeted medications used to treat pulmonary hypertension. Researchers will follow 700 patients every six months using a computerized tracking system to record any side effects and track survival rates. The goal is to better und…

This trial is testing if implanting a mechanical heart pump (HeartMate 3) early can help people with advanced heart failure live longer and have a better quality of life compared to staying on strong medications alone. It will enroll about 850 adults whose heart failure is worsen…

This study continues testing an experimental medicine for pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the heart and lungs. It follows 36 adults who already took the medicine in an earlier trial to check long-term safety and effects…

This study is testing whether an oral medication called levosimendan can help people who have both pulmonary hypertension (high blood pressure in the lungs) and a specific type of heart failure. About 230 participants will take either the medication or a placebo for 12 weeks to s…

This study is testing a stem cell transplant procedure for people with severe systemic sclerosis (scleroderma) that hasn't responded to other treatments. Doctors will use the patient's own filtered stem cells to try to 'reset' their faulty immune system after strong chemotherapy.…

This study is testing if adding one of two existing drugs (empagliflozin or ranolazine) to standard care helps people with right-sided heart failure caused by high lung blood pressure. It will enroll 30 adults to see if this approach is practical for a larger future trial. The ma…

This study is testing if a long-term, supervised exercise program can help people with pulmonary arterial hypertension (PAH). PAH is a serious lung and heart condition that makes people very short of breath. Researchers want to see if one year of specific aerobic and breathing ex…

This study is testing a new implantable device, the Aria CV Pulmonary Hypertension System, to see if it is safe and can help people with pulmonary hypertension and right heart dysfunction. Up to 30 adults who remain symptomatic despite standard medications will have the device im…

This study is testing whether a new drug, TX000045, can safely reduce high blood pressure in the lungs of people with a specific type of heart failure. About 180 participants will receive either the drug or a placebo via injection every two weeks for 24 weeks. Researchers will me…

This is the first study in people to test a new oral drug called F230, which is being developed to treat pulmonary hypertension—a serious condition of high blood pressure in the lungs. The main goal is to check if the drug is safe and how it moves through the body in 136 healthy …

This study is testing whether giving intravenous iron to people with pulmonary hypertension (high blood pressure in the lungs) and iron deficiency can help them walk farther and feel better. The trial will involve 306 patients who will receive either iron infusions or a placebo s…

This study is testing if the drug tadalafil can help people with COPD who also have severe high blood pressure in their lungs. About 200 participants will be randomly assigned to take either tadalafil or a placebo pill for 16 weeks. The main goal is to see if the drug improves ho…

This study is testing a new system to monitor and adjust oxygen therapy for premature babies at home. It aims to help babies with chronic lung disease safely stop using oxygen sooner. The project involves 70 infants across four hospitals in the Czech Republic, using remote sensor…

This study aims to see if changes in a person's voice can help detect pulmonary hypertension, a serious lung and heart condition. Researchers will analyze voice recordings from 7,000 patients who are already scheduled for heart ultrasound tests at Mayo Clinic. The goal is to dete…

This study is testing a new, non-invasive scanning method to diagnose high blood pressure in the lungs (pulmonary hypertension). Researchers will compare a safe, bedside scan using an electrode belt against the current invasive standard test in 120 patients. The goal is to see if…

This study aims to see if artificial intelligence (AI) can better screen for a serious lung complication called pulmonary arterial hypertension (PAH) in people with scleroderma. Researchers will compare new AI models against current screening methods using data from 350 patients.…

This study is testing whether a digital stethoscope that also records a simple heart tracing can use artificial intelligence (AI) to detect pulmonary hypertension, a serious condition of high blood pressure in the lungs. The goal is to create a faster, easier screening tool that …

This study aims to find the best combination of tests to spot pulmonary hypertension (high blood pressure in the lungs) earlier in people who have interstitial lung disease (scarring of the lungs). Researchers will gather detailed health information from 300 participants through …

This study aims to find out how accurate smartwatches are at measuring blood oxygen levels in people with pulmonary hypertension, a serious lung condition. Researchers will compare oxygen readings from a smartwatch to those from a standard finger clip monitor and a blood test, wh…

This study is testing whether the drug tadalafil can help reduce shortness of breath in Veterans who have both COPD and high blood pressure in their lungs. 126 participants will be randomly assigned to receive either tadalafil or a placebo pill for six months, and neither they no…

This study aims to learn more about a specific type of high blood pressure in the lungs (pulmonary hypertension) that can occur in people with COPD. Researchers will look back at the existing medical records of 1,000 patients who already had a specific heart test. The goal is to …

This online research study aims to understand how genetics influence a person's risk of developing pulmonary hypertension, a condition affecting blood pressure in the lungs. The study is recruiting 10,000 adults living in the United States, and participants do not need to have a …

This study aims to better understand heart and lung vessel diseases by comparing different measurement techniques. Researchers will enroll 3,000 patients who are already scheduled for a standard invasive heart pressure test. They will compare results from that test with non-invas…

This study aims to better understand a serious condition where high blood pressure develops in the lungs due to underlying lung scarring. Researchers will follow 1,000 patients for up to 5 years to track their health, treatments, and quality of life. The goal is to gather real-wo…

This national registry aims to understand how people with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are diagnosed and treated across the United States. It will follow 3,000 patients over time to see if care follows recommended…

This study is creating and testing a questionnaire to find out what patients with pulmonary arterial hypertension (PAH) know about their condition. Researchers will work with about 200 patients to make sure the questions are clear and measure knowledge accurately. The goal is to …

This study is testing whether a special type of MRI scan using Xenon gas can provide a clearer picture of lung damage in people with pulmonary hypertension. Researchers will scan 60 patients to see if the images match actual lung tissue damage and if the scans can help predict ho…

This study aims to understand if weakness in the main breathing muscle (the diaphragm) is common in people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension, and if it can predict future health problems. Researchers will measure muscle strength, lung funct…

This study aims to test a new risk score designed to predict one-year survival in people who have both chronic lung disease and high blood pressure in their lungs. Researchers will follow 100 patients for a year to see if the score accurately identifies who is at highest risk. Th…

This study aims to learn how chronic obstructive pulmonary disease (COPD) affects the heart, especially during exercise. Researchers will measure heart function in 60 people with COPD at rest and during different exercise intensities. The goal is to identify patterns of heart str…

This study is testing whether a special type of lung scan using xenon gas can better measure how well a new drug (sotatercept) works for people with pulmonary arterial hypertension (PAH). Researchers will scan the lungs of 14 participants before they start the drug and again afte…

This study is testing a new tool to measure how pulmonary hypertension affects a person's ability to do everyday tasks. Researchers will ask 32 adults with the condition to perform a series of simulated daily activities while their oxygen use is monitored. The goal is to see if t…

This study aims to understand how pulmonary arterial hypertension (PAH) progresses over time by tracking 270 adults, including patients and healthy volunteers. Researchers will collect blood samples and perform heart and lung scans to identify new biological markers that could im…

This study aims to find better ways to spot and understand right heart failure in people who have a weakened main heart pump and high blood pressure in their lungs. Researchers will test 50 patients during exercise and take tiny heart tissue samples to look for early signs of mus…

This study aims to better understand pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers will take two small blood samples from 100 adult patients during a standard diagnostic heart catheterization procedure. By analyzing these samples and trackin…

This study is creating a large collection of blood samples and health information from adults with congenital heart disease and related conditions. Researchers will follow 5000 participants over time to gather data that will help future studies understand how these heart conditio…

This study aims to see if a simple 2-minute step-in-place test can be used instead of the standard 6-minute walk test to measure exercise ability in people with pulmonary hypertension. Researchers will compare the results of both tests in 35 adults with the condition. The goal is…

This study is testing a new device called HemoCept during right heart catheterization procedures. Researchers want to see how well the device's measurements match standard pressure readings taken during these heart tests. The study involves 50 adults who are already scheduled for…

This study aims to collect detailed health information and blood samples from people with pulmonary hypertension (PH) or at risk for it. By gathering data from about 900 participants over time, researchers hope to better understand how different forms of PH develop and progress. …

This study aims to create a single, large registry to collect information on many different rare diseases. It will enroll about 380 patients already being treated at the Hospital Italiano de Buenos Aires who have one of the listed rare conditions. The goal is to gather data to be…

This study aims to find better ways to predict which cancer patients might develop heart or lung problems after receiving radiation therapy to the chest. Researchers will use a special combined PET/MRI scan and blood tests to look for early signs of damage in 40 adult patients. T…