PULMONARY HYPERTENSION

This study tests an inhaled drug called frespaciguat (MK-5475) in 129 adults who have high blood pressure in their lungs caused by COPD. The main goal is to see if the drug helps people walk farther in 6 minutes after 24 weeks compared to a placebo. Participants take one daily in…

This study looks at whether the drug bevacizumab can help people with a rare condition called hereditary hemorrhagic telangiectasia (HHT) who have severe liver problems leading to high heart output and possible heart failure. Researchers will check heart function before and after…

This Phase 2 trial tests an inhaled medication called mosliciguat in 135 people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs. Participants are randomly assigned to receive either the drug or a placebo for 16 weeks. The study measure…

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug remains s…

This study tests whether waiting to clamp the umbilical cord until after the baby's lungs have filled with air can reduce dangerous lung blood pressure (pulmonary hypertension) in newborns with congenital diaphragmatic hernia (CDH). About 140 infants with left-sided CDH will be r…

This study looks at whether a new computer program called IMPULSE can better detect pulmonary hypertension (high blood pressure in the lungs) using standard heart ultrasound. About 200 adults with unexplained breathlessness or risk factors will be checked. The goal is to see if t…

This study tests whether 10 weeks of supervised exercise training can improve heart function, oxygen use, and quality of life in people with heart failure and pulmonary hypertension. Forty participants will do three sessions per week at a cardiac rehab clinic. The goal is to see …

This study tests whether six weeks of daily breathing exercises against resistance can improve heart and lung function in people with pulmonary hypertension. Four participants will do 30 resisted breaths per day, five days a week. Researchers will measure changes in heart pressur…

This study looks at whether a 2-minute step test can accurately measure exercise ability in people with pulmonary hypertension, compared to the standard 6-minute walk test. Researchers will enroll 35 adults with the condition and measure oxygen use, heart rate, and breathlessness…

This study looks at whether adding special blood tests (biomarkers) to the usual heart-lung exam can help doctors pick the right therapy for people with pulmonary hypertension. About 100 adults undergoing a routine heart catheterization will have extra blood samples taken from th…

This study was designed to find early warning signs of high blood pressure in the lungs after mitral valve surgery. Researchers planned to use blood tests and heart imaging to detect problems that could be deadly if missed. The study was withdrawn before enrolling any participant…

This study is collecting blood samples from 550 adults with different types of pulmonary hypertension to measure two proteins, Activin-A and FSTL3. Researchers want to see if these proteins can predict who will need a lung transplant or die within two years. The goal is to find a…

This study looks at nearly 1,200 people with or at risk for pulmonary hypertension (high blood pressure in the lungs). Researchers use many advanced tests to find new ways to classify the disease and identify biomarkers. The goal is to better understand the disease and improve fu…

This observational study follows 350 adults with pulmonary hypertension to see if certain biomarkers in urine and blood are linked to worsening kidney function. Participants undergo standard tests but receive no experimental treatment. The goal is to better understand how kidney …

This study looks at whether wearing an activity tracker (like a Fitbit) can better predict how people with pulmonary hypertension will do over 12 weeks compared to the standard 6-minute walk test. About 230 participants will wear the tracker and report how they feel. The goal is …