PULMONARY HYPERTENSION

This study tests the safety of an inhaled dry powder drug called LIQ861 (treprostinil) in 80 adults with pulmonary hypertension (high blood pressure in the lungs) linked to lung disease. Participants receive the drug through an inhaler, and researchers monitor for side effects. T…

This study looks at whether the drug bevacizumab can help people with hereditary hemorrhagic telangiectasia (HHT) who have severe liver issues causing high heart output and possible heart failure. Researchers will track heart function before and after treatment in about 111 parti…

This study looks at 140 babies born with a hole in their diaphragm (congenital diaphragmatic hernia). Doctors want to see if waiting to clamp the umbilical cord until after the baby's lungs have filled with air can lower the risk of dangerous high blood pressure in the lungs. The…

This study tests an experimental drug called MK-5475 (frespaciguat) in 129 adults who have high blood pressure in the lungs caused by chronic lung disease (COPD). The main goal is to see if the drug helps people walk farther in 6 minutes after 24 weeks compared to a placebo. The …

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who have already been in earlier ralinepag studies will take the drug and be monitored f…

This study tests an inhaled medicine called mosliciguat in 135 people who have high blood pressure in their lungs due to scarring lung disease. The goal is to see if it improves blood flow and walking ability over 16 weeks. Participants are randomly assigned to receive the drug o…

This study tests whether special screening methods can find pulmonary hypertension (high blood pressure in the lungs) earlier in people with interstitial lung disease. About 300 adults with various types of ILD will be screened using heart catheterization to confirm the condition…

This study is testing a new computer method called the IMPULSE algorithm to see if it can spot pulmonary hypertension (high blood pressure in the lungs) better than current guidelines. It involves 200 patients who are already getting a standard heart ultrasound scan for unexplain…

This study looks at whether a supervised exercise program can improve heart function and quality of life for people with heart failure and pulmonary hypertension (high blood pressure in the lungs). Researchers will measure oxygen use during exercise and blood pressure in the lung…

This small study tests whether six weeks of special breathing exercises (called inspiratory muscle strength training) can improve heart and lung function in people with pulmonary hypertension, a condition where blood pressure in the lungs is too high. Four participants will do th…

This study was designed to look for early signs of lung blood pressure problems in adults after mitral valve surgery. Researchers planned to use blood tests and heart imaging to find hidden risks. However, the study was withdrawn before enrolling any participants.

This study checks if a 2-minute step test works as well as the standard 6-minute walk test for people with pulmonary hypertension. About 35 adults will do both tests while wearing a portable device that measures oxygen use and heart rate. The goal is to see if the shorter, simple…

This study looks at whether measuring certain substances in the blood of people with pulmonary hypertension (PH) can help doctors pick the best treatment. About 100 adults getting a standard heart test for PH will also have these extra measurements. The goal is to see if this lea…

This study is investigating whether two substances in the blood, Activin-A and FSTL3, can help predict how well people with pulmonary hypertension will do over time. Researchers will follow 550 adults with different types of this condition to see if these markers are linked to th…

This study examines the connection between certain biomarkers (substances in urine and blood) and kidney function decline in 350 adults with pulmonary hypertension, a type of high blood pressure affecting the lungs. Participants undergo a heart procedure and are followed to see i…

This study looks at whether wearing an activity tracker (like a Fitbit) can better predict how people with pulmonary hypertension will do over 12 weeks compared to the standard 6-minute walk test. About 230 participants will wear the tracker and report how they feel. The goal is …