PULMONARY HYPERTENSION

This study continues testing ralinepag, an experimental medication for pulmonary arterial hypertension (PAH), to understand its long-term safety and effectiveness. It enrolls 1,000 participants who have already taken ralinepag in previous studies and are already on standard PAH m…

This study is testing the safety and side effects of a new dry powder inhaler version of a medication called treprostinil. It involves about 80 adults with pulmonary hypertension, a serious condition of high blood pressure in the lungs, often linked to lung scarring. The main goa…

This study is testing whether a drug called bevacizumab can help people with hereditary hemorrhagic telangiectasia (HHT) who have severe liver problems that are putting extra strain on their heart. It will involve 111 patients in France who are already receiving this drug through…

This study is testing whether an experimental drug called MK-5475 can help adults who have high blood pressure in their lungs (pulmonary hypertension) caused by chronic obstructive pulmonary disease (COPD). The main goal is to see if people taking the drug can walk farther in six…

This study is testing whether waiting to clamp the umbilical cord until after a baby's lungs start working can help prevent dangerous high blood pressure in the lungs of newborns with a rare birth defect called congenital diaphragmatic hernia. Researchers are comparing this delay…

This study aims to check the long-term safety of an inhaled powder called TPIP for people with high blood pressure in the lungs linked to lung scarring (PH-ILD). It is open only to people who finished a previous related study. Researchers will monitor side effects and see if the …

This study is testing whether an inhaled drug called mosliciguat is safe and effective for people who have high blood pressure in their lungs (pulmonary hypertension) caused by underlying lung scarring (interstitial lung disease). About 135 participants will be randomly assigned …

This study is testing whether an artificial intelligence (AI) tool that analyzes a simple heart tracing (ECG) can help doctors find a dangerous condition called pulmonary hypertension in people who already have scarred lungs (ILD). About 1,000 participants will be randomly assign…

This study is testing a new heart scan method called the IMPULSE algorithm to see if it can better detect high blood pressure in the lungs (pulmonary hypertension). It involves 200 UK patients who have unexplained breathlessness or risk factors for the condition. The goal is to s…

This study is testing whether a six-week breathing exercise program can help people with pulmonary hypertension. Participants will use a special device to strengthen their breathing muscles before a scheduled medical check-up. Researchers want to see if this training reduces lung…

This study is testing whether measuring specific substances in blood samples taken during a standard heart catheterization procedure can help doctors make more informed treatment choices for pulmonary hypertension. Researchers will analyze blood from 100 adults already scheduled …

This study aims to find out if two specific proteins in the blood, called Activin-A and FSTL3, can help doctors predict how patients with pulmonary hypertension will fare over time. It will follow 550 adults with different types of this serious lung and heart condition. The goal …

This study aimed to understand how heart valve surgery affects lung blood pressure. Researchers planned to check blood samples and heart ultrasounds from patients before and after their procedures. The goal was to find early warning signs of a dangerous lung condition that can de…

This study aims to understand why kidney disease is common and dangerous in people with pulmonary hypertension (a serious heart-lung condition). Researchers will check blood and urine samples from 350 hospitalized patients to look for substances that might signal early kidney dam…

This study is testing whether daily activity data from wearable trackers can better predict health outcomes for people with pulmonary hypertension than the standard six-minute walk test. Researchers will follow 230 participants for up to four years, having them wear activity moni…