PULMONARY HYPERTENSION

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…

This study tested a device called the Atrial Flow Regulator (AFR) in 32 people with severe pulmonary hypertension, a condition of high blood pressure in the lungs. The device creates a small, controlled hole in the heart to relieve pressure. The main goal was to check safety and …

This study looked at the long-term safety of an inhaled medication called treprostinil palmitil (TPIP) for people with pulmonary hypertension caused by interstitial lung disease. Thirty-one adults who completed a previous study took part. The main goal was to check for side effec…

This study tested a single intravenous infusion of stem cells from donated umbilical cord tissue in one person with severe scleroderma that had caused lung scarring and high blood pressure in the lungs. The goal was to see if the treatment could improve lung function, exercise ab…

This study tested two drugs, levosimendan and dobutamine, in 52 adults undergoing heart valve replacement. The goal was to see which one better preserves right ventricular function after surgery. Patients were randomly assigned to receive one of the drugs, and their heart functio…

This pilot study tested a procedure called pulmonary artery denervation (PADN) in 30 adults with combined high blood pressure in the lungs and chronic heart failure. The procedure uses radiofrequency energy to disrupt certain nerves in the lung's blood vessels, aiming to lower pr…

This study tested whether a special MRI technique called 4D flow can accurately measure blood pressure in the lungs of people with pulmonary hypertension. 28 patients had both the MRI and the standard invasive catheterization to compare results. If the MRI proves reliable, it cou…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This study tested a dynamic blended learning module for 49 people with pulmonary hypertension, a chronic disease causing symptoms like shortness of breath and fatigue. The program included face-to-face education, regular phone follow-ups, and a video from a patient who successful…

This study compared the short-term effects of active video games versus traditional exercise in 16 adults with pulmonary hypertension. Participants did both types of exercise on separate days, and researchers measured heart rate, blood pressure, oxygen levels, and enjoyment. The …

This study tested whether 8 weeks of inspiratory muscle training (breathing exercises using a device) could improve exercise capacity in 32 people with pulmonary hypertension. Participants were randomly assigned to either active training or a placebo version. The goal was to see …

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study tested whether a special type of CT scan (dual energy CT) can help doctors better understand and predict the severity of pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers looked at lung images from 60 adults already diagnosed with the…

This study looked at ways to screen for pulmonary hypertension (high blood pressure in the lungs) in people who already have interstitial lung disease. The goal was to find this complication earlier. 314 adults with various types of lung disease took part in the screening tests.

This study tested whether a protocol that measures how well people with pulmonary hypertension perform everyday tasks (like arranging objects and walking with weights) is valid and reliable. Forty adults with the condition completed the five-station test twice. The goal was to se…

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at 623 adults with heart failure or high blood pressure in the lungs to see how well different tests measure pressure inside the heart. Doctors used both non-invasive ultrasound (echocardiogram) and invasive catheter measurements to check for elevated filling pr…

This study reviewed medical records of 59 adults with COPD to see if a standard pulmonary rehabilitation program is safe and effective for those who also have pulmonary hypertension (high blood pressure in the lungs). Researchers compared how much walking distance improved in peo…