New procedure targets lung pressure in heart failure: pilot study complete
NCT ID NCT05996562
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested a procedure called pulmonary artery denervation (PADN) in 30 adults with combined high blood pressure in the lungs and chronic heart failure. The procedure uses radiofrequency energy to disrupt certain nerves in the lung's blood vessels, aiming to lower pressure and improve exercise capacity. Participants were followed for one year to check safety and effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pulmonary artery denervation (a procedure using radiofrequency ablation to disrupt nerves in the lung's blood vessels)
What this could lead to
If this works, it could offer a new way to improve exercise ability and manage combined lung and heart pressure problems in people with chronic heart failure.
What could go wrong
This is a small pilot study with only 30 people, so results may not apply to everyone. The procedure involves risks like bleeding or vessel damage, and it's too early to know if it's truly effective.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital de Santa Marta
Lisbon, Portugal