Pulmonary hypertension

This early-phase trial tests an experimental antibody called DIAG723 in 93 adults with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. The study will check if the drug is safe and how the body processes it, with…

This phase 2 study tests whether spironolactone, a drug already used for fluid retention, can improve exercise capacity and blood vessel function in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will receive either spironolactone or a placebo for 24 …

This study tests an inhaled medicine called L606 for people with high blood pressure in the lungs due to lung disease. About 344 adults will be randomly assigned to receive L606 or a placebo. The main goal is to see if L606 helps them walk farther in six minutes and delays worsen…

This long-term study follows people with pulmonary arterial hypertension (PAH) who previously took part in sotatercept trials. Sotatercept is a targeted therapy that aims to stop PAH from getting worse. Researchers will monitor safety, side effects, and how well patients tolerate…

This study is testing the safety of an inhaled dry powder form of treprostinil (LIQ861) for people with pulmonary hypertension (high blood pressure in the lungs) due to lung disease. About 80 adults will take the drug using a special inhaler, and researchers will monitor for side…

This study tests whether giving two inhaled drugs (milrinone and epoprostenol) before heart-lung bypass can prevent difficult separation from the machine. About 141 adults having heart surgery will be randomly assigned to receive the drug combo or a placebo. The goal is to see if…

This study tests a procedure called pulmonary artery denervation (PADN) for people who still have high blood pressure in their lung arteries after a mitral valve repair. The procedure uses a catheter to deliver radiofrequency energy to specific nerve points in the main pulmonary …

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests an experimental drug called REGN13335 in 99 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive either the drug or a placebo, on top of their usual PAH medica…

This study tests whether different oxygen targets (higher vs. lower) improve outcomes in 39 preterm infants with bronchopulmonary dysplasia and pulmonary hypertension. Each infant will experience both oxygen levels in a crossover design. The goal is to see which level reduces dan…

This study offers continued access to the inhaled drug TPIP for people with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (PH-ILD) who have already completed a related study. Participants must have successfully finished prior …

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This phase 3 trial is testing whether a once-daily inhaled medication called treprostinil palmitil can help adults with pulmonary arterial hypertension (PAH) walk farther. About 344 participants will receive either the drug or a placebo for 24 weeks. The main goal is to see if th…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study follows 280 adults and children with pulmonary hypertension who are already taking macitentan or selexipag in a previous trial. The goal is to monitor long-term safety, including side effects and serious events, while allowing continued access to the medication. Partic…

This study tests whether implanted monitors can quickly show if a new PAH drug is working. About 40 adults with stable PAH will try two different approved drug plans while their heart and lung function are tracked. The goal is to see if this approach can help doctors choose the b…

This phase 1 trial tests the safety of a new drug called ZMA001 in 96 healthy adults. ZMA001 is a monoclonal antibody designed to reduce lung damage in pulmonary arterial hypertension (PAH), a serious condition. Participants receive a single dose of the drug or placebo and are mo…

This study tests whether the drug sotatercept can improve how well the lungs transfer oxygen in people with pulmonary arterial hypertension (PAH). Twenty-seven adults with PAH will receive the drug every 21 days for 29 weeks and undergo lung function tests, heart ultrasounds, and…

This study tests an experimental oral drug called ROC-101 in 40 adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (ILD-PH). Participants take the drug alongside their standard care for 24 weeks, with a long-term follow…

This phase 3 trial tests an inhaled drug called treprostinil palmitil in 344 adults with pulmonary hypertension caused by interstitial lung disease. Participants take the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them walk farther in six…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study tests whether adding Qishen Yiqi Dropping Pills, a Chinese herbal medicine, to standard therapy can improve exercise ability and quality of life in 120 adults with severe pulmonary hypertension. Participants will be randomly assigned to receive either the herbal pills …

This study is testing a new medicine called PF-07868489 for people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lung arteries makes the heart work harder. The study is open-label, meaning everyone knows they are getting the drug, and it…

This study tests an investigational drug called IMC-003 in 120 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants receive multiple injections of the drug or a placebo, alongside their usual treatments. The go…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study compares starting with two oral medications (tadalafil and ambrisentan) versus one medication alone in people newly diagnosed with pulmonary arterial hypertension (PAH) who also have at least two heart-related conditions. The goal is to see if the two-drug approach lea…

This study tests an experimental drug called IKT-001 in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. About 486 adults will receive either IKT-001 or a placebo to see if the drug improves b…

This Phase 2 trial tests an experimental drug called APL-9796 in 48 adults with pulmonary hypertension (high blood pressure in the lungs). The study aims to see if the drug is safe, tolerable, and effective. Participants receive injections under the skin, and researchers monitor …

This study is testing whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). Researchers will give 60 adults either valsartan or a placebo for 24 weeks to see if it improves how far they can walk in six minutes …

This early-phase study tests whether an oral supplement called L-Citrulline is safe for preterm babies born at or before 30 weeks who have lung problems (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of a natural substance in the blood can reduce…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests an experimental drug called LTP001 for pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard for the heart to pump blood. The trial has two parts: first, healthy volunteers receive single or multiple doses to check safety and how the …

This early-stage study is testing whether artesunate, a drug used for malaria, is safe for people with pulmonary arterial hypertension (PAH). Fifteen adults with PAH will take increasing doses of artesunate capsules for 20 weeks. The main goal is to check for side effects, not ye…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by lung scarring. The goal is to see if the combination is safe and tolerable. About 20 adults with this condition will particip…

This study tests a drug called sotatercept in 42 children aged 1 to 18 who have pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. The drug is given as a shot every 3 weeks, and the main goal is to see if it is safe and how the bod…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests whether adding macitentan to the standard drug dapagliflozin improves outcomes for people with heart failure and a specific type of high blood pressure in the lungs. 64 adults in South Korea will take either the combo or dapagliflozin alone for 24 weeks. Research…

This early-stage study tests a new way to use a heart-lung machine (ECMO) in 4 people waiting for a lung transplant who also have heart failure from high blood pressure in the lungs. The goal is to see if this approach can keep them alive and stable until they receive a transplan…

This study tests a device called the Alma system for women who have severe bleeding after childbirth that does not stop with standard treatments. About 50 women who experience heavy bleeding after vaginal or C-section delivery will be enrolled. If usual care fails, the Alma syste…

This study tests an experimental drug called TX000045 in 180 adults with pulmonary hypertension (high blood pressure in the lungs) caused by a type of heart failure where the heart pumps normally but doesn't relax properly. Participants will receive either the drug or a placebo f…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This early-stage study tests whether empagliflozin, a drug used for diabetes, can help people with pulmonary arterial hypertension (PAH). About 72 adults will take either the drug or a placebo daily for 12 weeks. Researchers will check if it lowers lung blood pressure and improve…

This study tests whether sildenafil (the drug in Viagra) can help people with severe lung high blood pressure caused by long-term rheumatic heart valve disease. Researchers will give 100 participants either sildenafil or a placebo three times daily for six weeks. The main goal is…

This study tests whether extra guidance from a pharmacist can help people with pulmonary arterial hypertension (PAH) use their inhaled iloprost correctly and consistently. PAH is a rare, serious lung condition that makes it hard to breathe. The trial will enroll 72 adults who alr…

This study tests a procedure called FETO for unborn babies with a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm has a hole and the lungs don't grow well. Doctors place a tiny balloon in the baby's windpipe to block it, which may help the lungs expand a…

This study tests an oral medication called levosimendan in people who have both pulmonary hypertension (high blood pressure in the lungs) and a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug helps them walk farther in 6 minutes c…

This pilot study tests two medicines, dopamine and norepinephrine, in 30 full-term or near-term newborns with low blood pressure and lung problems caused by pulmonary hypertension. The goal is to see which drug better improves blood flow and oxygen levels. Results could help doct…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study tests whether giving iron through a vein can help people with pulmonary hypertension (high blood pressure in the lungs) who also have low iron levels. Many patients with this condition have trouble absorbing iron from pills. The trial will compare intravenous iron to a…

This study tests whether adding the drug sotatercept to usual treatments can improve exercise ability in adults with pulmonary arterial hypertension (PAH) from unrepaired heart defects, including Eisenmenger syndrome. About 36 adults in Japan will be randomly assigned to receive …

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with severe pulmonary hypertension caused by chronic obstructive pulmonary disease (COPD). About 200 adults with both conditions will receive either tadalafil or a placebo daily for 16…

This early-stage trial tests the safety of a single inhaled dose of L608 in 32 healthy volunteers. L608 is a liposomal formulation designed to treat pulmonary arterial hypertension, a condition of high blood pressure in the lungs. The study compares different doses against a plac…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study tests whether combining two medications (Riociguat and Macitentan) with a balloon procedure to open blocked lung arteries can improve heart function in people with chronic thromboembolic pulmonary hypertension (CTEPH). The trial enrolls 15 adults who cannot have surger…

This study tests a stem cell transplant using the patient's own blood cells to treat severe scleroderma (systemic sclerosis) that hasn't improved with standard drugs. The goal is to see if this high-dose therapy is safe and can stop the disease from getting worse. The trial enrol…

This phase 2 trial tests whether sildenafil, a drug used for pulmonary hypertension, can help people with scleroderma who have mildly elevated lung pressures. Thirty participants will receive either sildenafil or a placebo for 4 months. The main goal is to see if the drug improve…

This early-stage trial tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe for people with pulmonary arterial hypertension (PAH). 24 adults with PAH will be randomly assigned to receive either the bacteria capsules or a placebo.…

This study tests a drug called mirivadelgat in people with high blood pressure in the lungs caused by lung scarring (PH-ILD). The goal is to see if it improves blood flow in the lungs, exercise ability, and overall well-being. About 126 participants will take the drug or a placeb…

This study tests a new device for people with pulmonary hypertension, a condition where high blood pressure strains the heart. The device is implanted to help the heart pump better. About 30 adults with severe symptoms will take part to see if the device is safe and works well.

This study tests whether the drug sotatercept can improve right heart function in people with pulmonary arterial hypertension (PAH). PAH causes high blood pressure in the lungs, straining the right side of the heart. Sotatercept targets the underlying blood vessel changes, not ju…

This phase 3 trial tests a procedure called FETO, where a balloon is placed in the windpipe of a fetus to help lungs grow. It is for pregnant women carrying a baby with severe congenital diaphragmatic hernia, a condition where the diaphragm has a hole and organs move into the che…

This phase 2 trial is testing whether two existing drugs, empagliflozin (used for diabetes) and ranolazine (used for chest pain), can improve right heart function in 30 people with pulmonary hypertension and right heart failure. Participants will receive one of the drugs plus sta…

This study tests a remote monitoring system using pulse oximeters to optimize oxygen therapy in premature infants with bronchopulmonary dysplasia (BPD). Researchers aim to reduce the time babies need oxygen and prevent complications like pulmonary hypertension. The trial involves…

This study tests whether a long-term rehabilitation program—combining home exercise and breathing muscle training—can improve clinical outcomes and heart-lung function in people with pulmonary arterial hypertension. About 104 adults with stable disease will be randomly assigned t…

This study tests whether an artificial intelligence (AI) tool that analyzes a simple ECG can help doctors find undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be random…

This study is testing whether a digital stethoscope, combined with artificial intelligence, can detect two serious conditions: high blood pressure in the lungs (pulmonary hypertension) and a weak heart pump (low ejection fraction). About 3,850 adults will have their heart sounds …

This study is testing whether a digital stethoscope and a simple heart monitor (ECG) can detect pulmonary hypertension, a serious condition where blood pressure in the lungs is too high. About 1,500 adults who are already scheduled for heart tests will have their heart sounds and…

This study is testing whether a special digital stethoscope, combined with artificial intelligence, can detect pulmonary hypertension (high blood pressure in the lungs) by listening to heart sounds and recording a single-lead ECG. Researchers will enroll over 2,400 adults who are…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study looks for early signs of pulmonary hypertension (high blood pressure in the lungs) in people with chronic lung diseases like COPD or pulmonary fibrosis. Researchers will analyze collagen fragments in blood and lung tissue to create a 'fingerprint' that could lead to si…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study tests whether a non-invasive device called electrical impedance tomography (EIT) can accurately diagnose pulmonary hypertension, a serious lung condition. Currently, diagnosis requires an invasive procedure called right heart catheterization. Researchers will compare E…

This study tests whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) can detect pulmonary hypertension—a serious condition where blood pressure in the lungs is dangerously high—in people aged 50 to 85 who are at risk. Over 8,600 participants will get the AI-ECG…

This study tests whether inhaling a special form of xenon gas during an MRI can help doctors see and measure blood vessel changes in the lungs of people with pulmonary arterial hypertension (PAH). The goal is to find a non-invasive way to diagnose different types of PAH and track…

This early-phase study tests whether a special PET scan tracer, 18F-fluoroglutamine, can detect pulmonary arterial hypertension (PAH) earlier and more accurately. PAH is a serious disease of the lung's blood vessels that often goes undiagnosed for years. The study will scan 71 ad…

This study at Mayo Clinic is testing whether voice recordings can help detect pulmonary hypertension, a serious condition affecting the heart and lungs. Researchers will collect voice samples from 7,000 people already scheduled for an echocardiogram. The goal is to see if voice p…

This study is looking for specific protein patterns in the blood that could help diagnose chronic thromboembolic pulmonary hypertension (CTEPH), a rare but serious complication of blood clots in the lungs. Researchers will analyze blood samples from 120 people suspected of having…

This study is testing a standard screening method to find a condition called chronic thromboembolic pulmonary hypertension (CTEPH) in people who had a blood clot in their lungs 3 to 12 months earlier. Researchers will check if certain tests, like heart ultrasound or lung scans, c…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study is testing whether a new risk score called PVD-B65 can accurately predict who will survive for one year after being diagnosed with pulmonary hypertension related to chronic lung disease. Researchers will follow 100 adults and track deaths and other health changes. The …

This study is testing a smartphone app called MedlyPeds that lets children with heart disease send their weight, blood pressure, and heart rate to their doctors from home. The app also asks about symptoms and sends personalized tips. The goal is to see if the app is easy to use a…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study tests whether a 12-week home-based exercise program, started soon after diagnosis, improves walking distance and quality of life in people with pulmonary hypertension. Forty participants will either exercise early or wait six months. The goal is to see if exercise plus…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether supervised exercise sessions done at home through video calls can improve breathing, fatigue, and quality of life in people with elevated pulmonary artery pressure. Twelve adults with stable symptoms will be randomly assigned to either telerehabilitation …

This study tests whether a 16-week home exercise program, guided by a smartwatch, can help children aged 8-18 with pulmonary hypertension become more active and improve their muscle strength and quality of life. Participants will wear activity trackers and follow a personalized e…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This study tests whether a mobile health program can help adolescents with pulmonary arterial hypertension increase their daily step counts. About 50 teens aged 10-21 will use a Fitbit and receive coaching to boost activity over 12 weeks. The goal is to improve exercise and quali…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study looks at whether Street Racket, a simple racket sport, can be added to standard pulmonary rehabilitation for people with chronic lung disease. Twelve participants will play Street Racket every two weeks during their rehab program. Researchers will measure how acceptabl…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a home rehabilitation program using daily text or email messages with simple exercises can reduce the number of heartbeats needed during a 6-minute walk in people with pulmonary arterial hypertension (PAH). Researchers will enroll 55 adults with PAH and c…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This study tests whether a 12-week home exercise program can improve exercise capacity and quality of life in 20 adults with pulmonary arterial hypertension (PAH). Participants receive guidance from a physiotherapist to do endurance and strength training at home. The main goal is…

This natural history study follows 270 adults with pulmonary arterial hypertension (PAH) and healthy volunteers to track how the disease changes over time. Researchers will use blood tests, heart and lung imaging, and a six-minute walk test to find new markers of disease severity…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study follows up to 3,500 people with sickle cell disease to learn more about how the condition progresses and what complications arise. Participants receive their usual medical care outside the hospital and visit the clinic for check-ups and research tests. No experimental …

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study looks at whether detailed heart scans (echocardiograms and MRIs) can improve how doctors predict short-term risks in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension). Researchers will follow 50 adults for 6 months to see if addin…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This observational study will follow 5000 people with pulmonary hypertension to understand a severe complication called pulmonary hypertension crisis. Researchers will collect medical data and samples to build a risk prediction tool. The goal is to identify who is at risk and imp…

This study follows 50 adults who have had pulmonary endarterectomy surgery for chronic blood clots in the lungs. Researchers will measure walking ability, muscle strength, lung function, and frailty before and after surgery. The goal is to understand how recovery progresses and w…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study is a registry that will follow about 900 adults with both interstitial lung disease and pulmonary hypertension. Researchers will collect information on patients' medical history and track changes in their condition over time. The goal is to better understand these dise…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study examines why fat accumulates in the right ventricle of people with pulmonary arterial hypertension (PAH) and how it affects heart function and exercise ability. Researchers will use MRI and blood tests in 75 adults with PAH to track changes over time. The goal is to be…

This study follows 27 pregnant women living at high altitude in Bolivia and compares them to women at sea level. Researchers will use heart ultrasounds and blood tests to see how the body adapts to low oxygen levels during pregnancy. The goal is to better understand why some wome…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study looks at how changing the pressure on a ventilator affects the lungs and heart of very premature babies (born before 34 weeks). Researchers will try different pressure levels and use ultrasound and imaging to see which setting works best for breathing and blood flow. T…

This study looks at why people with pulmonary arterial hypertension (PAH) lose muscle mass and how that affects their daily life and activity. Researchers will measure body composition, heart fat, diet, and physical function in 150 adults with PAH. No new treatment is being teste…

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart strain to help develop better treatments in the future. About 60 adults aged 40 and older with COPD will…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers will use heart imaging and other tests to identify different patterns of heart dysfunction. The goal is to better understand these patterns so that future …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study tests whether nicotinamide riboside, a form of vitamin B3, can improve how cells produce energy in people with combined pulmonary hypertension (CPH). CPH is a serious lung and heart condition with no approved treatments. Ten participants will receive both the supplemen…

This study is tracking 70 adults on long-term dialysis to find out how often they develop high blood pressure in the lungs (pulmonary hypertension) and what causes it. Participants get heart ultrasounds and, if needed, more tests to confirm the condition. Researchers will follow …

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study aims to find genes that make some people with congenital heart defects develop a serious lung condition called pulmonary arterial hypertension (PAH). Researchers will analyze DNA from blood samples of 21 patients with heart defects who also have PAH. The goal is to ide…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study looks at whether giving mothers in Brazil an extra $40 per month (compared to just $2) can protect their children's brain development and mental health. About 450 children aged 7-10 from low-income families will be followed for 2 years. Researchers will measure stress,…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study looks at how a specific biological pathway (BMPR2-activin) affects pulmonary hypertension in people with left heart disease. Researchers will follow 150 heart failure patients for one year, using blood tests, imaging, and heart tissue analysis. The goal is to better un…

This study is testing a new device called HemoCept during a standard heart procedure called right heart catheterization. The goal is to see if the device can accurately measure pressure in the heart's blood vessels. About 50 adults with conditions like pulmonary hypertension or h…

This study looks at whether a special heart pressure wave test can better track recovery in adults with chronic blood clots in the lungs (CTEPH) who are getting a procedure to open blocked arteries (balloon pulmonary angioplasty). Researchers will measure walking distance, heart …

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study is an observational registry that will follow about 120 adults with pulmonary hypertension who are being treated with the drug sotatercept at the Mayo Clinic. Researchers will track changes in quality of life, exercise ability, heart function, and side effects like ble…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is creating a large database of children with pulmonary hypertension (high blood pressure in the lungs) to better understand how the disease progresses and how treatments work in real life. Researchers will follow 450 children and adolescents over time, collecting info…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study is building a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health. No treatments or …

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This early-stage study tests a new tablet called F230 in 136 healthy adults to see if it is safe and how the body processes it. The drug is designed to treat pulmonary hypertension, a serious lung condition. Researchers will also check if food changes how the drug works. This stu…

This study is looking at people with pulmonary arterial hypertension (PAH), those with a genetic risk but no disease, and healthy individuals. Researchers aim to find molecular and physical markers that explain why some people get PAH and others stay healthy. The goal is to impro…

This study is creating and testing a questionnaire called SAVOIR to measure how much people with pulmonary arterial hypertension (PAH) understand about their condition. Up to 215 patients and expert judges will help ensure the questions are clear, relevant, and reliable. The goal…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study compares noninvasive heart ultrasound (echocardiogram) with the standard invasive right heart catheterization in 3000 people referred for catheterization. The goal is to see if ultrasound can accurately measure heart function and blood flow during exercise. Participant…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …

This study is testing whether a special MRI using inhaled xenon gas can track how well the drug sotatercept repairs blood vessels in the lungs of people with pulmonary arterial hypertension (PAH). Fourteen adults with PAH will have xenon MRI scans before and after starting sotate…

This study uses a safe, radiation-free device called electrical impedance tomography (EIT) to take pictures of the lungs in infants, children, and young adults up to age 25. Researchers will compare images from patients with chronic lung or heart conditions to healthy controls to…

This study looks at small molecules (metabolites) in the blood and urine of people with pulmonary hypertension caused by lung fibrosis. Researchers want to see how these metabolites change with treatment and whether they can tell who will respond well. The goal is to better under…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study checks if smartwatches can accurately measure oxygen levels in people with pulmonary hypertension, a condition that affects the lungs and heart. Twenty adults will have their oxygen levels checked by a smartwatch, a finger clip, and a blood test at rest, after exercise…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study looks at whether not using inhaled nitric oxide (iNO) in newborns with congenital diaphragmatic hernia (CDH) leads to better outcomes, like fewer needing life support or dying. About 600 babies from multiple hospitals will be included. The goal is to see if stopping th…

This study involves 100 people with suspected pulmonary hypertension who are already scheduled for a right heart catheterization. During the procedure, doctors will take two extra blood samples from a specific position in the lung artery to analyze oxygen and other gas levels. Th…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study looks at how the diaphragm, the main muscle used for breathing, works in people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. About 800 adults will take breat…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study looks back at medical records of 1,000 people with COPD who also had a special heart test called right heart catheterization. Researchers want to understand a specific lung-heart problem called pulmonary hypertension. By analyzing this data, they hope to better identif…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study is creating a large database of information from 900 people who have pulmonary hypertension (high blood pressure in the lungs) or are at risk for it. Researchers will collect medical history, test results, and follow-up data over time. The goal is to improve understand…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart tissue samples from 50 adults to find the best ways to diagnose and treat this condition. Participants must be bet…

This study looks at how balloon pulmonary angioplasty (BPA) changes heart and lung function in people with chronic blood clots in the lungs (CTEPH). Researchers will use advanced MRI scans before and after the procedure to measure blood flow and heart performance. The goal is to …

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study looks at how a surgery called pulmonary endarterectomy (PEA) affects the self-confidence of people with chronic thromboembolic pulmonary hypertension (CTEPH). Ten patients will fill out questionnaires about their confidence in managing their illness and communicating w…

This study is collecting information from 500 people with chronic thromboembolic pulmonary hypertension (CTEPH) in Russia. Researchers want to learn which factors most affect long-term survival and health. Participants will have their medical history, symptoms, and test results r…

This study is looking for early signs of heart and lung damage in people receiving radiation for chest cancers. Researchers will use PET/MR scans and blood tests before and after treatment to see if they can predict who will develop problems like pulmonary hypertension. The goal …

This study will follow at least 700 people with pulmonary hypertension to track side effects and deaths related to targeted medications. Participants will be checked every 6 months using a computer system. The goal is to better understand the safety of these drugs in real-world u…

This study aims to find out how often people develop a serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) after having a blood clot in the lungs (pulmonary embolism). Researchers will use heart ultrasounds to look for early signs of heart strain i…

This study is testing whether artificial intelligence (AI) can better detect a serious lung condition called pulmonary arterial hypertension (PAH) in people with scleroderma. Researchers will compare AI algorithms to traditional screening methods in 350 patients across multiple h…

This study is a national registry that collects information from 3,000 people with pulmonary hypertension (PH) treated at specialized centers across the U.S. Researchers will track how patients are diagnosed, treated, and how they do over time. The goal is to see if care follows …

This study is testing a device called Electrical Impedance Tomography (EIT) that uses electrodes to create images of the lungs without radiation. Researchers want to see if it can provide useful information about lung function in children with chronic respiratory diseases, includ…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study looks at how genes may increase the risk of pulmonary hypertension (high blood pressure in the lungs). Researchers will collect health surveys and saliva samples from 10,000 adults in the US, both with and without the condition. The goal is to find genetic links that c…

This study looks at how long it takes for people in Brazil to get a correct diagnosis of pulmonary arterial hypertension (PAH), a rare and serious lung disease. Researchers will review medical records of about 139 adults diagnosed in the last five years to find out what causes de…

This study looks at what happens when people with pulmonary arterial hypertension (PAH) switch from one medication (ambrisentan) to another (bosentan). Researchers will track 121 adults to see if their risk level, symptoms, and side effects change after the switch. The goal is to…

This study looks at how blood vessels control blood flow in healthy people and those with conditions like COPD, heart failure, and high blood pressure. Researchers will measure changes in blood flow and blood pressure after exercise and other tests. The goal is to understand why …

This study looks at how well tiny blood vessels in the lungs recover after a procedure called balloon pulmonary angioplasty (BPA) in people with chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH is a condition where old blood clots block lung arteries, making it hard t…

This study follows 150 people with Takayasu's arteritis that also affects the lung arteries. Researchers will track their health over time, including how far they can walk in six minutes and their risk of death. The goal is to better understand the disease and its long-term outlo…

This study looks at how hormones and metabolism are involved in pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will measure sex hormone levels, insulin resistance, and test two potential treatments—metformin and ACE-2—in small groups. The goal is to …

This study looks at whether the way blood cells work and handle stress can help doctors detect and predict the course of pre-capillary pulmonary hypertension, a serious lung condition. Researchers will collect blood samples from 120 patients during routine visits over three years…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…