A 30-Minute nailbed scan could reveal how lung treatments work
NCT ID NCT07768644
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This study explores whether a simple, radiation-free scan of the nailbeds—called nailfold capillaroscopy—can help diagnose and monitor pulmonary hypertension (PH), a condition of high blood pressure in the lungs. Researchers will compare nailbed blood vessel measurements with invasive heart catheter readings in 60 adults with different types of PH. They will also scan patients again after they start pulmonary vasodilator therapy to see if nailbed changes reverse with treatment, potentially offering a less invasive way to track response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pulmonary vasodilator therapy (including phosphodiesterase inhibitors, prostanoids, endothelin receptor antagonists, and activin ligand traps)
- What this could lead to
- If nailfold scans reliably reflect lung pressures, they could offer a quicker, non-invasive way to help diagnose and monitor pulmonary hypertension, potentially reducing the need for invasive catheter tests.
- What could go wrong
- This is a small, early-stage study. The nailfold changes may not correlate strongly with heart pressures, and any reversibility seen might not translate into a reliable clinical tool.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
NHS Golden Jubilee
RECRUITINGClydebank, West Dunbartonshire, G81 4DY, United Kingdom
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