New pill hopes to ease breathing in rare lung conditions
NCT ID NCT07175038
First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times
Summary
This study tests an experimental oral drug called ROC-101 in 40 adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (ILD-PH). Participants take the drug alongside their standard care for 24 weeks, with a long-term follow-up. The main goal is to see if the drug safely improves blood flow in the lungs and reduces symptoms like shortness of breath.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aou Policlinico Umberto I - Uoc Malattie Cardiovascolari (Padiglione Viii)
RECRUITINGRome, Rome, 00161, Italy
Contact Email: •••••@•••••
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Arizona Pulmonary Specialists
RECRUITINGPhoenix, Arizona, 85012, United States
Contact Email: •••••@•••••
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Bend Memorial Clinic
RECRUITINGBend, Oregon, 97701, United States
Contact Email: •••••@•••••
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CHU de BICETRE SERVICE PNEUMOLOGIE
RECRUITINGLe Kremlin-Bicêtre, Val-de-Marne, 94275, France
Contact Email: •••••@•••••
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Fondazione IRCCS Policlinico San Matteo
RECRUITINGPavia, Lombardy, 27100, Italy
Contact Email: •••••@•••••
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George Washington University Medical
RECRUITINGWashington D.C., District of Columbia, 20037, United States
Contact Email: •••••@•••••
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Madrid, 28041, Spain
Contact Email: •••••@•••••
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Hospital Universitario de Toledo
RECRUITINGToledo, Toledo, 45007, Spain
Contact Email: •••••@•••••
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Houston Methodist Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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London Health Ontario
RECRUITINGLondon, Ontario, N6A 5W9, Canada
Contact Email: •••••@•••••
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Mayo Clinic of Florida
RECRUITINGJacksonville, Florida, 32224, United States
Contact Email: •••••@•••••
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Medizinische Hochschule Hannover
RECRUITINGHanover, Lower Saxony, 30625, Germany
Contact Email: •••••@•••••
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Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
Contact Email: •••••@•••••
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Pauls Stradins Clinical University Hospital
RECRUITINGRiga, LV-1002, Latvia
Contact Email: •••••@•••••
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Peter Lougheed Centre
RECRUITINGCalgary, Alberta, T1Y 6J4, Canada
Contact Email: •••••@•••••
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Policlinico Riuniti di Foggia
RECRUITINGFoggia, Apulia, 71122, Italy
Contact Email: •••••@•••••
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Pulmonary Hypertension Research Queensland
RECRUITINGAuchenflower, Queensland, 4066, Australia
Contact Email: •••••@•••••
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Royal Prince Alfred Hospital
RECRUITINGCamperdown, New South Wales, 2050, Australia
Contact Email: •••••@•••••
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Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
Contact Email: •••••@•••••
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The University of Kansas Medical Center Research Institute
RECRUITINGKansas City, Kansas, 66160, United States
Contact Email: •••••@•••••
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University of California Davis Health
RECRUITINGRancho Cordova, California, 95670, United States
Contact Email: •••••@•••••
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact Email: •••••@•••••
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can an inhaled therapy replace a daily pill for PAH?
- Can a Real-World registry improve how treprostinil is used for PAH?
- Which PAH treatment strategy works better: adding a third drug or increasing the dose?
- Lung patients may soon do rehab from home via app
- Which drug is best for pulmonary hypertensive crisis? new trial aims to find out
- New PAH drug IKT-001 moves to Long-Term safety check