New drug combo could help heart defect patients with severe lung pressure

NCT ID NCT07356778

Recruiting now Disease control Sponsor: Kazuya Hosokawa Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding the drug sotatercept to usual treatments can improve exercise ability in adults with pulmonary arterial hypertension (PAH) from unrepaired heart defects, including Eisenmenger syndrome. About 36 adults in Japan will be randomly assigned to receive either sotatercept plus standard care or standard care alone for 24 weeks. The main goal is to see if the combination helps people walk farther in six minutes.

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Conditions

The condition(s) this trial relates to.

Eisenmenger syndrome pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EISENMENGER SYNDROME PULMONARY ARTERIAL HYPERTENSION OF CONGENITAL HEART DISEASE

Contacts and locations

Locations

Department of Cardiology, Keio University School of Medicine
RECRUITING

Tokyo, Japan
Department of Cardiology, Nagoya University Hospital
RECRUITING

Nagoya, Japan
Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
RECRUITING

Okayama, Japan
Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, Japan
Department of Cardiovascular Medicine, Kyorin University School of Medicine
RECRUITING

Tokyo, Japan
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
RECRUITING

Sendai, Japan
Division of Cardiovascular Medicine, Department of Internal Medicine, Showa University Graduate School of Medicine
RECRUITING

Tokyo, Japan
Division of Cardiovascular Medicine, Kobe University Hospital
RECRUITING

Kobe, Japan
Kyushu University Hospital
RECRUITING

Fukuoka, Not Required For This Country, 8150014, Japan
The Second Department of Internal Medicine, University of Occupational and Environmental Health
RECRUITING

Fukuoka, Japan

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