New drug combo could help heart defect patients with severe lung pressure
NCT ID NCT07356778
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the drug sotatercept to usual treatments can improve exercise ability in adults with pulmonary arterial hypertension (PAH) from unrepaired heart defects, including Eisenmenger syndrome. About 36 adults in Japan will be randomly assigned to receive either sotatercept plus standard care or standard care alone for 24 weeks. The main goal is to see if the combination helps people walk farther in six minutes.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Department of Cardiology, Keio University School of Medicine
RECRUITINGTokyo, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Cardiology, Nagoya University Hospital
RECRUITINGNagoya, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
RECRUITINGOkayama, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
RECRUITINGKyoto, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Cardiovascular Medicine, Kyorin University School of Medicine
RECRUITINGTokyo, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
RECRUITINGSendai, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Division of Cardiovascular Medicine, Department of Internal Medicine, Showa University Graduate School of Medicine
RECRUITINGTokyo, Japan
Contact Email: •••••@•••••
Contact
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Division of Cardiovascular Medicine, Kobe University Hospital
RECRUITINGKobe, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kyushu University Hospital
RECRUITINGFukuoka, Not Required For This Country, 8150014, Japan
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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The Second Department of Internal Medicine, University of Occupational and Environmental Health
RECRUITINGFukuoka, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact