Which drug works best for sick newborns? small trial aims to find out

NCT ID NCT07322133

Recruiting now Disease control Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This pilot study tests two medicines, dopamine and norepinephrine, in 30 full-term or near-term newborns with low blood pressure and lung problems caused by pulmonary hypertension. The goal is to see which drug better improves blood flow and oxygen levels. Results could help doctors choose the best first treatment for these fragile babies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dopamine and norepinephrine
What this could lead to: If this trial shows one drug works better, it could guide doctors in choosing the best treatment for newborns with this serious condition.
What could go wrong: This is a small pilot study with only 30 babies, so results may not apply to all newborns. The drugs may also have side effects like affecting heart function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder persistent fetal circulation syndrome pulmonary hypertension respiratory failure Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOTENSION AND SHOCK HYPOXEMIC RESPIRATORY FAILURE PULMONARY HYPERTENSION OF THE NEWBORN (PPHN)

Contacts and locations

Locations

UC Davis Children's Hospital
RECRUITING

Sacramento, California, 95817, United States

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