New care pathway aims to save lives of ICU patients with breathing failure
NCT ID NCT04744298
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a step-by-step care plan (called TheraPPP) helps patients with severe breathing failure (ARDS) survive and spend less time on a ventilator. The plan includes proven treatments like protective ventilation, paralysis, and prone positioning. About 20,000 adults in Alberta ICUs will be included. The goal is to make sure every patient gets the best known care.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chinook Regional Hospital
Lethbridge, Alberta, T1J 1W5, Canada
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Foothills Hospital Intensive Care Unit
Calgary, Alberta, T2N 2T9, Canada
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Foothills Medical Center Cardiovascular ICU
Calgary, Alberta, T2N 2T9, Canada
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Grey Nuns Community Hospital
Edmonton, Alberta, T6L 5X8, Canada
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Mazankowski Alberta Heart Institute
Edmonton, Alberta, T6G 2B7, Canada
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Medicine Hat Regional Hospital
Medicine Hat, Alberta, T1A 4H6, Canada
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Misericordia Community Hospital
Edmonton, Alberta, T5R 4H5, Canada
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Northern Lights Regional Health Centre
Fort McMurray, Alberta, T9H 1P2, Canada
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Peter Lougheed Centre (PLC)
Calgary, Alberta, T1Y 6J4, Canada
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Queen Elizabeth II Hospital
Grande Prairie, Alberta, T8V 2E8, Canada
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Red Deer Regional Hospital Centre
Red Deer, Alberta, T4N 4E7, Canada
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Rockyview General Hospital
Calgary, Alberta, T2V 1P9, Canada
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Royal Alexandra Hospital
Edmonton, Alberta, T5H 3V9, Canada
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South Health Campus
Calgary, Alberta, T3M 1M4, Canada
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Sturgeon Community Hospital
St. Albert, Alberta, T8N 6C4, Canada
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University of Alberta Hospital General Systems ICU
Edmonton, Alberta, T6G 2B7, Canada
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University of Alberta Hospital Neurosciences Intensive Care Unit
Edmonton, Alberta, T6G 2B7, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Lung-Opening maneuver change a key injury marker in ARDS?
- Could simply sitting up ease breathing in severe lung failure?
- Could lung fluid proteins reveal a new way to track severe lung injury?
- Could a spirometer test guide breathing support in respiratory failure?
- Which ventilator setting saves more lungs? a Head-to-Head test
- Can a single antibody turn down the immune storm in ARDS?