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Can High-Flow oxygen through a tracheostomy speed ventilator weaning?

NCT ID NCT07714564

Not yet recruiting Disease control Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial compares two oxygen methods for tracheostomized patients who are being weaned off a mechanical ventilator. Half receive high-flow oxygen directly into the tracheostomy tube, while the other half receive conventional oxygen. The goal is to see if high-flow oxygen helps more patients stay off the ventilator by day 7 and day 28.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tracheal high-flow oxygen therapy
What this could lead to
If effective, this approach could help critically ill patients with a tracheostomy breathe on their own sooner, reducing time on a ventilator and associated complications.
What could go wrong
This is an early-stage trial with 500 participants, and the benefit over conventional oxygen may be small or absent. Individual results may vary, and not all patients will be able to wean successfully.

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Conditions

The condition(s) this trial relates to.

respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOXEMIC RESPIRATORY FAILURE MECHANICAL VENTILATION TRACHEOSTOMY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • ICU, Fondazione Policlinico A. Gemelli IRCCS

    Rome, 00198, Italy

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